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公开(公告)号：US07534790B2
公开(公告)日：2009-05-19
申请号：US11944282
申请日：2007-11-21
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/426 , A61K31/403 , A61K31/4015 , A61K31/40 , C07D295/033 , C07D413/02 , C07D295/027 , C07D277/04 , C07D209/96 , C07D207/12
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US07101877B2
公开(公告)日：2006-09-05
申请号：US10674684
申请日：2003-09-29
申请人： Allen I Bain , Gregory N Beatch , Cindy J Longley , Bertrand M C Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
发明人： Allen I Bain , Gregory N Beatch , Cindy J Longley , Bertrand M C Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07875611B2
公开(公告)日：2011-01-25
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/40 , C07D265/30 , C07D207/04
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US20100029639A1
公开(公告)日：2010-02-04
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/32 , A61K31/5375 , A61K31/40 , C07D207/08 , C07D409/08 , A61P9/00
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US20110207730A1
公开(公告)日：2011-08-25
申请号：US12970532
申请日：2010-12-16
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/5375 , C07D207/325 , A61K31/40 , C07D413/02 , C07C211/38 , A61K31/135 , C07D241/06 , A61K31/4965 , C07D491/113 , A61K31/438 , C07D277/24 , A61K31/426 , A61P9/00 , C12N5/071
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US07345087B2
公开(公告)日：2008-03-18
申请号：US11394388
申请日：2006-03-30
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/40 , C07D207/12
CPC分类号： C07D207/12 , C07D207/08 , C07D207/10 , C07D207/20 , C07D207/24 , C07D277/04 , C07D295/096 , C07D333/56 , C07D405/12 , C07D487/12 , C07D491/10 , C07D491/113
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译： 公开了氨基环己基醚化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了化合物和组合物的用途，包括治疗心律失常。
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公开(公告)号：US07057053B2
公开(公告)日：2006-06-06
申请号：US11018428
申请日：2004-12-21
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： C07D207/12 , A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07259184B2
公开(公告)日：2007-08-21
申请号：US11342270
申请日：2006-01-27
申请人： Gregory N Beatch , Bertrand M C Plouvier , Tao Sheng , Michael J A Walker , Richard A Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
发明人： Gregory N Beatch , Bertrand M C Plouvier , Tao Sheng , Michael J A Walker , Richard A Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
IPC分类号： A61K31/4025 , C07D207/12
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US08008342B2
公开(公告)日：2011-08-30
申请号：US12412010
申请日：2009-03-26
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07524879B2
公开(公告)日：2009-04-28
申请号：US11757880
申请日：2007-06-04
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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