公开(公告)号：US20060199815A1

公开(公告)日：2006-09-07

申请号：US11358827

申请日：2006-02-21

申请人： Sunil Paliwal ,  Gregory Reichard ,  Cheng Wang ,  Dong Xiao ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Juan Arredondo ,  Michelle Wrobleski ,  Anandan Palani

发明人： Sunil Paliwal ,  Gregory Reichard ,  Cheng Wang ,  Dong Xiao ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Juan Arredondo ,  Michelle Wrobleski ,  Anandan Palani

IPC分类号： A61K31/538 ,  A61K31/498 ,  A61K31/4747

CPC分类号： C07D498/10 ,  A61K31/166 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/537 ,  A61K31/5377 ,  A61K31/573 ,  A61K45/06 ,  C07D207/14 ,  C07D207/50 ,  C07D211/28 ,  C07D211/32 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60 ,  C07D211/72 ,  C07D211/76 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/10 ,  C07D413/12 ,  C07D471/10 ,  C07D487/10 ,  C07D491/10 ,  C07D513/10

摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

摘要翻译： 具有式（I）的NK 1拮抗剂，其中Ar 1和Ar 2是任选取代的苯基或杂芳基，X 1 硫醚或亚氨基键，R 4和R 5不都是H或烷基，其余的变量如说明书中所定义， 可用于治疗许多障碍，包括呕吐，抑郁，焦虑和咳嗽。 药物组合物。 还公开了治疗方法和与其它药剂的组合。

公开(公告)号：US07498438B2

公开(公告)日：2009-03-03

申请号：US11100226

申请日：2005-04-06

申请人： Dong Xiao ,  Anandan Palani ,  Cheng Wang ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Gregory A. Reichard

发明人： Dong Xiao ,  Anandan Palani ,  Cheng Wang ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Gregory A. Reichard

IPC分类号： C07D471/02 ,  C07D491/02

CPC分类号： C07D471/04

摘要： A compound having the general structure shown in Formula 1: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

摘要翻译： 具有式1所示的一般结构的化合物或其药学上可接受的盐和/或溶剂化物可用于治疗由NK1受体介导的疾病或病症，例如各种生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽 。

公开(公告)号：US07354922B2

公开(公告)日：2008-04-08

申请号：US11291363

申请日：2005-12-01

申请人： Dong Xiao ,  Anandan Palani ,  Cheng Wang ,  Hon-Chung Tsui ,  Xianhai Huang ,  Sapna S. Shah ,  Ashwin U. Rao ,  Xiao Chen ,  Sunil Paliwal ,  Neng-Yang Shih

发明人： Dong Xiao ,  Anandan Palani ,  Cheng Wang ,  Hon-Chung Tsui ,  Xianhai Huang ,  Sapna S. Shah ,  Ashwin U. Rao ,  Xiao Chen ,  Sunil Paliwal ,  Neng-Yang Shih

IPC分类号： A01N43/58 ,  A01N43/60 ,  C07D245/00 ,  C07D241/36 ,  C07D471/00

CPC分类号： C07D471/08

摘要： A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

摘要翻译： 具有式（I）所示的一般结构的化合物或其药学上可接受的盐和/或溶剂化物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理紊乱，症状或 疾病包括呕吐，抑郁，焦虑和咳嗽。

公开(公告)号：US20060223804A1

公开(公告)日：2006-10-05

申请号：US11172289

申请日：2005-06-30

申请人： Sapna Shah ,  Neng-Yang Shih ,  Anandan Palani ,  Xianhai Huang ,  Dong Xiao ,  Sunil Paliwal ,  Hon-Chung Tsui ,  Michelle Wrobleski ,  Ashwin Rao ,  Cheng Wang

发明人： Sapna Shah ,  Neng-Yang Shih ,  Anandan Palani ,  Xianhai Huang ,  Dong Xiao ,  Sunil Paliwal ,  Hon-Chung Tsui ,  Michelle Wrobleski ,  Ashwin Rao ,  Cheng Wang

IPC分类号： A61K31/53 ,  A61K31/454 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D401/04 ,  A61K31/4178 ,  A61K31/451 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/573 ,  A61K45/06 ,  C07D211/56 ,  C07D211/60 ,  C07D211/66 ,  C07D211/76 ,  C07D413/04 ,  C07D417/04 ,  C07D498/20

摘要： A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

摘要翻译： 具有式I所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理疾病，症状或疾病， 包括呕吐，抑郁，焦虑和咳嗽。

公开(公告)号：US20060040975A1

公开(公告)日：2006-02-23

申请号：US11100226

申请日：2005-04-06

申请人： Dong Xiao ,  Anandan Palani ,  Cheng Wang ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Gregory Reichard

发明人： Dong Xiao ,  Anandan Palani ,  Cheng Wang ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Gregory Reichard

IPC分类号： C07D471/02 ,  A61K31/4745

CPC分类号： C07D471/04

摘要： A compound having the general structure shown in Formula 1: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

摘要翻译： 具有式1所示的一般结构的化合物或其药学上可接受的盐和/或溶剂合物可用于治疗由NK 1受体介导的疾病或病症，例如各种生理疾病，症状或疾病， 包括呕吐，抑郁，焦虑和咳嗽。

公开(公告)号：US07041682B2

公开(公告)日：2006-05-09

申请号：US10612176

申请日：2003-07-02

申请人： Neng-Yang Shih ,  Steven Wang ,  Gregory Reichard ,  Dong Xiao ,  Cheng Wang

发明人： Neng-Yang Shih ,  Steven Wang ,  Gregory Reichard ,  Dong Xiao ,  Cheng Wang

IPC分类号： A61K31/445 ,  C07D211/56

CPC分类号： C07D401/04 ,  C07D211/98 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are NK1 antagonists having the formula: Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough, using the compounds of formula (I).

摘要翻译： 公开了具有下式的NK 1拮抗剂：还公开了使用式（I）化合物治疗许多生理疾病，症状或疾病，包括呕吐，抑郁，焦虑和咳嗽的方法。

公开(公告)号：US20060094720A1

公开(公告)日：2006-05-04

申请号：US11300848

申请日：2005-12-15

申请人： Neng-Yang Shih ,  Steven Wang ,  Gregory Reichard ,  Dong Xiao ,  Cheng Wang

发明人： Neng-Yang Shih ,  Steven Wang ,  Gregory Reichard ,  Dong Xiao ,  Cheng Wang

IPC分类号： A61K31/5377 ,  A61K31/454 ,  A61K31/453 ,  C07D409/02 ,  C07D413/02

CPC分类号： C07D401/04 ,  C07D211/98 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Disclosed are NK1 antagonists having the formula: Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough, using the compounds of formula (I).

公开(公告)号：US09982863B2

公开(公告)日：2018-05-29

申请号：US15045336

申请日：2016-02-17

申请人： Cheng Wang

发明人： Cheng Wang

IPC分类号： F21S8/10 ,  F21Y105/12

CPC分类号： F21S41/143 ,  F21S41/255 ,  F21S41/26 ,  F21S41/265 ,  F21S41/60 ,  F21S41/663 ,  F21Y2105/12

摘要： The instant disclosure illustrates a light distance-adjustable vehicle lamp including a lens unit, a light emitting group and a datum axis. The lens unit includes a first focus, a second focus, a lens focus and an optical axis. The light emitting group includes a first light emitting unit and a second light emitting unit. The first light emitting unit includes a first light source center, a first axis and a first light emitting surface, the first light emitting unit corresponds to the first focus of the lens unit. The second light emitting unit includes a second light source center, a second axis and a second light emitting focus. The datum axis passes through the lens focus and the second light emitting unit.

公开(公告)号：US09786942B2

公开(公告)日：2017-10-10

申请号：US13730881

申请日：2012-12-29

申请人： Jian-Wei Guo ,  Xiao-Lin Xie ,  Cheng Wang ,  Xiang-Ming He ,  Wen-Juan Wei ,  Chen-Chen Zhao

发明人： Jian-Wei Guo ,  Xiao-Lin Xie ,  Cheng Wang ,  Xiang-Ming He ,  Wen-Juan Wei ,  Chen-Chen Zhao

IPC分类号： H01M8/10 ,  H01M8/1004 ,  H01M4/90 ,  H01M4/92 ,  H01M8/1007 ,  B82Y30/00

CPC分类号： H01M8/1004 ,  B82Y30/00 ,  H01M4/9083 ,  H01M4/926 ,  H01M8/1007

摘要： A membrane electrode includes a first electrode, a second electrode, and a proton exchange membrane sandwiched between the first electrode and the second electrode. The first electrode includes a first gas diffusion layer and a first catalyst layer. The second electrode includes a second gas diffusion layer and a second catalyst layer. The first catalyst layer or the second catalyst layer includes a carbon nanotube-metal particle composite including carbon nanotubes, polymer layer, and metal particles. The polymer layer is coated on a surface of the carbon nanotubes and defines a plurality of pores uniformly distributed; the metal particles are located in the pores. A fuel cell including the membrane electrode is also disclosed.

公开(公告)号：US09637793B2

公开(公告)日：2017-05-02

申请号：US13518801

申请日：2009-12-24

申请人： Chenyu Zhang ,  Rui Liu ,  Cheng Wang ,  Yi Bai ,  Chunni Zhang ,  Ke Zeng

发明人： Chenyu Zhang ,  Rui Liu ,  Cheng Wang ,  Yi Bai ,  Chunni Zhang ,  Ke Zeng

IPC分类号： C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q1/6813 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q2600/158 ,  C12Q2600/178 ,  C40B40/06

摘要： The present invention provides microRNAs for assessing the status of pancreatic cancer in a subject, and provides methods, kits, and biochips for detecting said microRNAs.