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    Apparatus for growing tissue cultures in vitro
    11.
    发明授权
    Apparatus for growing tissue cultures in vitro 失效
    用于体外培养组织培养物的装置

    公开(公告)号：US5215920A

    公开(公告)日：1993-06-01

    申请号：US695300

    申请日：1991-05-03

    Applicant: George Lyman ,  Gregory Mathus ,  David Root

    Inventor： George Lyman ,  Gregory Mathus ,  David Root

    IPC: C12M1/20 ,  C12M1/22 ,  C12M3/00 ,  C12M3/06

    CPC classification number: C12M29/04 ,  C12M25/04

    Abstract: Apparatus for growing tissue cultures in vitro, which permits a concentration gradient of nutrients to develop through a permeable membrane to which a sample of tissue is attached. The permeable membrane is attached to the bottom end of a tubular support that in turn hangs by a flange connected to its upper end on the top of a well containing the nutrients. Typically, the well is part of a tissue culture cluster dish. The flange of the support positions the support and membrane centrally in the well so as to avoid capillary action in the space between the well and support. The configuration of the support and its cooperation with the lid of the cluster dish also prevents the support and membrane from floating in the nutrient solution in the well. Openings in the support provide access for a pipette to add and withdraw fluid from the space between the well and membrane support and from the space below the membrane.

    Abstract translation: 用于在体外生长组织培养物的装置，其允许营养物的浓度梯度通过附着有组织样品的渗透膜发育。 可渗透膜附接到管状支撑件的底端，管状支撑件的底端又通过连接到容纳营养物质的孔的顶部上方的凸缘而悬挂。 通常，孔是组织培养簇盘的一部分。 支撑件的凸缘将支撑件和膜中心定位在井中，以避免在井和支撑件之间的空间中的毛细作用。 支架的配置及其与簇盘盖的配合也可防止支撑和膜浮在井中的营养液中。 支架中的开口提供移液管的通道，以从孔和膜支撑之间的空间以及膜下方的空间添加和抽出流体。

    Multiwell filter plate vacuum manifold assembly
    12.
    发明授权
    Multiwell filter plate vacuum manifold assembly 失效
    多孔过滤板真空歧管总成

    公开(公告)号：US4927604A

    公开(公告)日：1990-05-22

    申请号：US280170

    申请日：1988-12-05

    Applicant: Gregory Mathus ,  George Lyman

    Inventor： Gregory Mathus ,  George Lyman

    IPC: B01D29/05 ,  B01D61/18 ,  B01L3/00

    CPC classification number: B01D61/18 ,  B01D29/05 ,  B01L3/50255 ,  Y10T436/255

    Abstract: A filtration system for handling an array of filter wells which are open at the top and closed by a filter membrane at the bottom. The system includes a manifold chamber defined by side and bottom walls and having a support for the wells which carries the filter membranes above the bottom walls so that filtrate may be drawn through the membranes. A vacuum fitting is connected to the chamber so that a low pressure source may be applied thereto, and a sealing sheet extends over the wells and having holes aligned with the open tops of the wells so that when the low pressure is applied to the chamber, filtrate may be drawn through the membrane.

    Abstract translation: 一个过滤系统，用于处理在顶部开放并由底部的过滤膜封闭的过滤器孔阵列。 该系统包括由侧壁和底壁限定的歧管室，并具有用于在底壁上方承载过滤膜的孔的支撑，使得滤液可以通过膜抽吸。 真空接头连接到腔室，以便可以向其施加低压源，并且密封片在井上延伸并且具有与孔的开口顶部对准的孔，使得当低压施加到腔室时， 滤液可以通过膜抽吸。

    Multi-channel pipetter
    13.
    发明授权
    Multi-channel pipetter 失效
    多通道移液器

    公开(公告)号：US4824642A

    公开(公告)日：1989-04-25

    申请号：US921319

    申请日：1986-10-21

    Applicant: George Lyman ,  Gregory Mathus

    Inventor： George Lyman ,  Gregory Mathus

    IPC: G01N1/00 ,  B01L3/02 ,  G01N35/10 ,  G01N1/14

    CPC classification number: B01L3/0224 ,  G01N35/1065 ,  Y10S436/809

    Abstract: A multi-channel pipetter has a U-shaped housing with horizontal upper and lower arms and an interconnecting hand grip portion. A plurality of nozzles that serve to support replaceable tips are mounted on the lower arm in a vertical orientation and are connected by a flexible tubing that extends upwardly through the grip portion to a circular array of cylinders disposed horizontally in the upper arm. A piston-cylinder-volume setting mechanism is horizontally disposed in the upper arm. The mechanism is actuated by a trigger on the hand grip portion and the volume is controlled by a micrometer head which operates a stop within the upper arm. A tip ejector is mounted in the lower arm which provides substantial mechanical advantage for stripping the tips from the nozzles.

    Abstract translation: 多通道移液器具有U形壳体，其具有水平上臂和下臂以及互连的手柄部分。 用于支撑可替换的尖端的多个喷嘴以垂直取向安装在下臂上，并且通过柔性管连接，柔性管向上延伸穿过把手部分到水平放置在上臂中的圆形圆柱形阵列。 水平地设置在上臂中的活塞缸体积设定机构。 该机构由手握部分上的触发器致动，并且该体积由在上臂中操作停止的测微头来控制。 尖端喷射器安装在下臂中，其为从喷嘴剥离尖端提供了实质的机械优点。

    Method of using a disposable pipette tip
    15.
    发明申请
    Method of using a disposable pipette tip 有权
    使用一次性吸头的方法

    公开(公告)号：US20130306155A1

    公开(公告)日：2013-11-21

    申请号：US13952731

    申请日：2013-07-29

    Applicant: Gregory Mathus ,  Terrance Kelly ,  Richard Cote

    Inventor： Gregory Mathus ,  Terrance Kelly ,  Richard Cote

    IPC: B01L3/02

    CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

    Abstract: The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.

    Abstract translation: 移液方法涉及安装和喷射一次性吸头。 移液系统具有一个或多个具有上部锁定部分和下部密封部分的尖端安装轴。 上锁定部分具有围绕安装轴间隔开并位于止动件上方的向外延伸的凸角。 刀片安装轴上的下密封部分位于挡块下方。 当安装轴插入到一次性移液管的轴环中时，套环从圆形变形并与尖端安装轴的上部锁定部分上的凸角接合。 同时，安装轴的下密封部分密封在一次性移液管尖端的筒体上。

    Sample Reservoir Kits with Disposable Liners
    17.
    发明申请
    Sample Reservoir Kits with Disposable Liners 审中-公开
    带一次性衬套的样品储液罐套件

    公开(公告)号：US20110005956A1

    公开(公告)日：2011-01-13

    申请号：US12885953

    申请日：2010-09-20

    Applicant: Gregory Mathus ,  Terrence Kelly

    Inventor： Gregory Mathus ,  Terrence Kelly

    IPC: B65D85/00 ,  G01F23/00

    CPC classification number: B01L3/508 ,  B01L3/021 ,  B01L3/505 ,  B01L2300/028 ,  B01L2300/0854

    Abstract: A liquid sample or liquid reagent reservoir kit employs a reusable reservoir base and disposable liners made of a clear transparent plastic material. Graduation marks are located on the sidewall surface of the basin in the reusable reservoir base, and are calibrated to measure liquid volumes in a disposable liner placed within the reusable reservoir base. The transparency of the clear disposable liner allows the liquid volume graduation marks on the sidewall of the basin in the reusable base to be observed through the disposable liner. The disposable liners are configured so that the liners can also be used as a cover. The geometry of the disposable liners facilitates tight nesting of stacked liners to facilitate shipping as well as storage on the laboratory bench top.

    Abstract translation: 液体样品或液体试剂储存器套件采用可重复使用的储存器底座和由透明透明塑料材料制成的一次性衬垫。 刻度标记位于可重复使用的储存器底座中的盆的侧壁表面上，并且被校准以测量放置在可重复使用的储存器底座内的一次性衬垫中的液体体积。 透明一次性衬垫的透明度允许通过一次性衬垫观察可重复使用的底座中的盆的侧壁上的液体体积刻度。 一次性衬垫被构造成使得衬垫也可以用作罩。 一次性衬垫的几何形状有助于堆叠衬垫的紧密嵌套，以便于运输以及实验室台面上的储存。

    Tube rack
    19.
    发明授权
    Tube rack 有权
    管架

    公开(公告)号：US06875405B1

    公开(公告)日：2005-04-05

    申请号：US09457796

    申请日：1999-12-09

    Applicant: Gregory Mathus ,  Daniel J. Seguin ,  Victor A. Torti

    Inventor： Gregory Mathus ,  Daniel J. Seguin ,  Victor A. Torti

    IPC: B01L3/00 ,  B01L9/00 ,  B01L9/06

    CPC classification number: B01L9/06 ,  Y10S435/809

    Abstract: A tube rack comprises a base having an array of vertical openings extending therebetween, the openings being configured and dimensioned to receive a plurality of tubes, with the upper ends of the tubes being accessible at the top surface. The base includes base sidewalls that each include a co-axial trunnion extending from the associated sidewall. The tube rack also includes a rotatable and removable cover having a front wall, a back wall and first and second sidewalls, wherein the first and second side walls each include an associated notch open on a bottom surface thereof to allow the cover to be lowered onto the base, such that each of the notches rests on its associated trunnion and may be (i) vertically raised from its closed position on the trunnions and (ii) rotated about the trunnions from its closed position to allow access to the array of openings, wherein each of the notches includes a trunnion travel surface and a ledge surface and the ledge surface engages its associated trunnion to limit rotation of the cover beyond its full cover position. Each of the openings comprises a plurality of support pads positioned within the opening to vertically support the tube within its associated opening. Each of the pads includes a chamfered concave surface that supportably engages the tube, while providing flow paths through which air may pass through the openings adjacent to the tube.

    Abstract translation: 管架包括具有在其间延伸的垂直开口阵列的基座，该开口被构造和尺寸设计成容纳多个管，其中管的上端可在顶表面处接近。 基部包括基部侧壁，每个侧壁包括从相关联的侧壁延伸的同轴耳轴。 管架还包括具有前壁，后壁和第一和第二侧壁的可旋转和可移除的盖，其中第一和第二侧壁各自包括在其底表面上开口的相关凹口，以允许盖降低到 基座，使得每个凹口位于其相关联的耳轴上，并且可以（i）从其在耳轴上的关闭位置垂直地升高，并且（ii）围绕耳轴从其关闭位置旋转以允许接近开口阵列， 其中每个凹口包括耳轴移动表面和凸缘表面，并且凸缘表面接合其相关联的耳轴以限制盖的旋转超过其完全覆盖位置。 每个开口包括定位在开口内的多个支撑垫，以将管垂直地支撑在其相关联的开口内。 每个焊盘包括可支撑地接合管的倒角凹面，同时提供空气可以穿过邻近管的开口的流动路径。

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