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公开(公告)号：US20130196449A1
公开(公告)日：2013-08-01
申请号：US13801227
申请日：2013-03-13
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Ansoon Kim , Huei Pei Kuo , Zhiyong Li , Steven J. Barcelo , Zhang-Lin Zhou , Gary Gibson
IPC: G01N21/65
CPC classification number: G01N21/658
Abstract: An electrically driven device for surface enhanced Raman spectroscopy includes a substrate, a Raman signal-amplifying structure positioned on the substrate, and an analyte receptor attached to a structure chosen from i) the Raman signal-amplifying structure, or ii) the substrate near the Raman signal-amplifying structure, or iii) combinations of i and ii. The analyte receptor has a selective binding affinity for an analyte. Conductive elements are positioned relative to one another and to the analyte receptor such that the conductive elements together produce an electric field in the vicinity of the analyte receptor when a voltage bias is applied between the conductive elements.
Abstract translation: 用于表面增强拉曼光谱的电驱动器件包括衬底，位于衬底上的拉曼信号放大结构和附着于从i）拉曼信号放大结构的结构的分析物受体，或ii） 拉曼信号放大结构，或iii）i和ii的组合。 分析物受体对分析物具有选择性结合亲和力。 导电元件相对于彼此和分析物受体定位，使得当在导电元件之间施加电压偏压时，导电元件在分析物接收体附近一起产生电场。
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公开(公告)号：US20170254754A1
公开(公告)日：2017-09-07
申请号：US15604558
申请日：2017-05-24
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Gary Gibson , Huei Pei Kuo , Steven J. Barcelo , Zhiyong Li
CPC classification number: G01N21/658 , G01J3/4412 , G01N21/21
Abstract: Polarization selective surface enhanced Raman spectroscopy (SERS) includes a plurality of nanofingers arranged as a SERS multimer to exhibit a polarization-dependent plasmonic mode and one or both of a stimulus source and a Raman detector. The stimulus source is to illuminate the SERS multimer with a stimulus signal and the Raman detector is to detect a Raman scattering signal emitted by an analyte in a vicinity of the SERS multimer. One or both of the Raman scattering signal has a polarization state dictated by or associated with the polarization-dependent plasmonic mode and the stimulus signal has a polarization state corresponding to the polarization-dependent plasmonic mode.
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公开(公告)号：US09476833B2
公开(公告)日：2016-10-25
申请号：US13754404
申请日：2013-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Steven J. Barcelo , Zhiyong Li , Ansoon Kim , Zhang-Lin Zhou , Gary Gibson
CPC classification number: G01N21/658 , B82Y40/00 , Y10S977/882
Abstract: According to an example, methods for forming three-dimensional (3-D) nano-particle assemblies include depositing SES elements onto respective tips of nano-fingers, in which the nano-fingers are arranged in sufficiently close proximities to each other to enable the tips of groups of adjacent ones of the nano-fingers to come into sufficiently close proximities to each other to enable the SES elements on the tips to be bonded together when the nano-fingers are partially collapsed. The methods also include causing the nano-fingers to partially collapse toward adjacent ones of the nano-fingers to cause a plurality of SES elements on respective groups of the nano-fingers to be in relatively close proximities to each other and form respective clusters of SES elements, introducing additional particles that are to attach onto the clusters of SES elements, and causing the clusters of SES elements to detach from the nano-fingers.
Abstract translation: 根据一个实例，用于形成三维（3-D）纳米颗粒组件的方法包括将SES元件沉积到纳米手指的各个尖端上，其中纳米手指以彼此足够接近的方式排列，使得 纳米手指的相邻组的尖端彼此靠近，使得当纳米手指被部分折叠时，尖端上的SES元件能够结合在一起。 所述方法还包括使纳米指部分相对于纳米手指部分地折叠，以使纳米手指的相应组上的多个SES元件彼此相对接近并形成相应的SES簇 引入附加到SES元件簇上的附加颗粒，并使SES元件簇与纳米手指分离。
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14.发明申请MULTIPLE SPECTRAL MEASUREMENT ACQUISITION APPARATUS AND THE METHODS OF USING SAME 审中-公开多种光谱测量采集装置及其使用方法公开(公告)号：US20150211998A1
公开(公告)日：2015-07-30
申请号：US14414206
申请日：2012-10-31
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Huei Pei Kuo , Zhiyong Li , Shih-Yuan Wang , Alexandre M. Bratkovski , Steven Barcelo , Ansoon Kim , Gary Gibson , Mineo Yamakawa
CPC classification number: G01N21/65 , G01N21/64 , G01N2201/06113
Abstract: A system includes an illumination source, a detector and a processor. The detector acquires spectral measurements of a sample under test under at least one varying condition. The processor processes the measurements to generate at least one spectral representation that includes Raman spectra and at least one spectral representation that includes non-Raman spectra.
Abstract translation: 系统包括照明源，检测器和处理器。 检测器在至少一个变化的条件下获得被测样品的光谱测量。 处理器处理测量以产生包括拉曼光谱和包括非拉曼光谱的至少一个光谱表示的至少一个光谱表示。
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公开(公告)号：US08670119B1
公开(公告)日：2014-03-11
申请号：US13754456
申请日：2013-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Alexandre M Bratkovski , Zhiyong Li , Gary Gibson
IPC: G01J3/44
CPC classification number: G01J3/44 , G01N21/05 , G01N21/648 , G01N21/658
Abstract: According to an example, an apparatus for performing spectroscopy includes a perimeter wall extending between a first end and a second end of the perimeter wall along a first axis, in which an interior surface of the perimeter wall forms a hollow core extending along the first axis. The perimeter wall has openings at both the first end and the second end and light is to pass through the perimeter wall. The apparatus also includes a plurality of SES modules positioned around an inner circumference of the perimeter wall in a spaced arrangement with respect to each other to allow light to enter into the hollow core in gaps between the plurality of SES modules, in which each of the plurality of SES modules is positioned substantially across from a gap.
Abstract translation: 根据一个示例，用于执行光谱学的装置包括沿着第一轴线在周边壁的第一端和第二端之间延伸的周边壁，周边壁的内表面形成沿着第一轴延伸的中空芯 。 周边壁在第一端和第二端均具有开口，并且光穿过周边壁。 所述设备还包括多个SES模块，所述多个SES模块以相对于彼此间隔开的布置围绕所述周壁的内周定位，以允许光在所述多个SES模块之间的间隙中进入所述中空芯， 多个SES模块基本上跨过间隙定位。
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Patent Agency Ranking
公开(公告)号：US20160103074A1
公开(公告)日：2016-04-14
申请号：US14968314
申请日：2015-12-14
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Shih-Yuan Wang , Huei Pei Kuo , Steven J. Barcelo , Zhang-Lin Zhou
IPC: G01N21/65
CPC classification number: G01N21/658 , B82Y15/00 , G01J3/4412 , G01N2021/651 , G01N2201/06113 , Y10S977/902
Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.
Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。
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公开(公告)号：US20160003748A1
公开(公告)日：2016-01-07
申请号：US14763510
申请日：2013-01-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P
Inventor： Gary Gibson , Huei Pei Kuo , Steven J. Barcelo , Zhiyong Li
CPC classification number: G01N21/658 , G01J3/4412 , G01N21/21 , G01N2201/06113 , G01N2201/0683
Abstract: Polarization selective surface enhanced Raman spectroscopy (SERS) includes a plurality of nanofingers arranged as a SERS multimer to exhibit a polarization-dependent plasmonic mode and one or both of a stimulus source and a Raman detector. The stimulus source is to illuminate the SERS multimer with a stimulus signal and the Raman detector is to detect a Raman scattering signal emitted by an analyte in a vicinity of the SERS multimer. One or both of the Raman scattering signal has a polarization state dictated by or associated with the polarization-dependent plasmonic mode and the stimulus signal has a polarization state corresponding to the polarization-dependent plasmonic mode.
Abstract translation: 极化选择性表面增强拉曼光谱（SERS）包括布置为SERS多聚体的多个纳米针，以表现出偏振相关等离子体激发模式以及刺激源和拉曼检测器中的一个或两个。 刺激源是用刺激信号照亮SERS多聚体，并且拉曼检测器检测由SERS多聚体附近的分析物发射的拉曼散射信号。 拉曼散射信号中的一个或两个具有由偏振相关等离子体激发模式指示或关联的偏振状态，并且刺激信号具有对应于偏振相关等离子体激发模式的偏振状态。
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公开(公告)号：US09074937B2
公开(公告)日：2015-07-07
申请号：US13754283
申请日：2013-01-30
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Huei Pei Kuo , Zhiyong Li , Shih-Yuan Wang , Steven J. Barcelo , Ansoon Kim , Gary Gibson , Alexandre M Bratkovski
CPC classification number: G01J3/44 , G01J3/0208 , G01J3/0294 , G01J3/2803 , G01J3/4406
Abstract: According to an example, apparatuses for performing multiple concurrent spectral analyzes on a sample under test include an optical system to concurrently direct a plurality of light beams onto analytes at multiple locations on the sample under test, in which the plurality of light beams cause light in either or both of a Raman spectra and a non-Raman spectra to be emitted from the analytes at the multiple locations of the sample under test. The apparatuses also include a detector to concurrently acquire a plurality of spectral measurements of the light emitted from the analytes at the multiple locations of the sample under test. Example methods of performing spectral analysis include use of the apparatuses.
Abstract translation: 根据一个示例，用于对被测试样品进行多次同时光谱分析的装置包括：一个光学系统，用于将多个光束同时引导到被测样品上的多个位置上的分析物上，其中多个光束使得光 在待测样品的多个位置处从分析物中发射的拉曼光谱和非拉曼光谱中的任一者或两者。 这些装置还包括一个检测器，用于同时获取在待测试样品的多个位置处从分析物发射的光的多个光谱测量。 执行光谱分析的示例方法包括使用这些装置。
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公开(公告)号：US20140268128A1
公开(公告)日：2014-09-18
申请号：US13797880
申请日：2013-03-12
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Huei Pei Kuo , Alexandre M. Bratkovski , Zhang-Lin Zhou
IPC: G01N21/65
CPC classification number: G01N21/658
Abstract: Self-exciting surface enhanced Raman spectroscopy (SERS) employs an integral optical excitation source to provide an excitation signal to provide self-excitation of a SERS structure. The SERS structure includes a plurality of nanofingers having SERS-enhancing nanoparticles disposed adjacent to the nanofingers.
Abstract translation: 自激表面增强拉曼光谱（SERS）采用积分光学激发源来提供激发信号以提供SERS结构的自激。 SERS结构包括具有邻近纳米装置设置的具有SERS增强纳米颗粒的多个纳米涂层。
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公开(公告)号：US20140211206A1
公开(公告)日：2014-07-31
申请号：US13750848
申请日：2013-01-25
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Shih-Yuan Wang , Huei Pei Kuo , Zhiyong Li , Gary Gibson
CPC classification number: G01N1/00 , A61B5/0075 , A61B5/1459 , A61B5/6847 , A61B2562/028 , A61B2562/0285 , G01N1/02 , G01N21/658 , Y10T29/49826
Abstract: According to an example, an apparatus for collecting a material to be spectrally analyzed includes a body having a first end and a second end, in which the body is elongated along a first axis from the first end to the second end. The body also includes a hole having an opening formed in an external surface of the body at a location between the first end and the second end and extending at least partially through the body at an angle with respect to the first axis. The body further includes a plurality of surface-enhanced spectroscopy (SES) elements positioned inside the body.
Abstract translation: 根据一个示例，用于收集要被光谱分析的材料的装置包括具有第一端和第二端的主体，其中主体沿着第一轴从第一端延伸到第二端。 主体还包括孔，该孔具有在主体的外表面上形成在第一端和第二端之间的位置的开口，并且至少部分地穿过主体相对于第一轴线成一定角度延伸。 身体还包括位于体内的多个表面增强光谱（SES）元件。
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