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公开(公告)号：US4198480A
公开(公告)日：1980-04-15
申请号：US886987
申请日：1978-03-15
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号： C12P1/06 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465
CPC分类号： C12R1/465 , C07H15/252 , C12P19/56 , Y10S435/886
摘要： A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
摘要翻译： 本文称为鲍曼霉素复合物的新型蒽环类抗生素复合物是通过发酵生产巴霉素的链霉菌菌株，例如， Streptomyces coeruleorubidus ME 130-A4（FERM-P3540，ATCC 31276）。 其中称为baumycin A1，A2，B1和B2的复合物和四种生物活性成分可用作抗细菌剂和抗肿瘤剂。
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公开(公告)号：US3992524A
公开(公告)日：1976-11-16
申请号：US555011
申请日：1975-03-03
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Akira Takamatsu , Toshikazu Oki , Hiroshi Tone
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Akira Takamatsu , Toshikazu Oki , Hiroshi Tone
CPC分类号： A61K36/06 , C07G11/00 , Y10S435/886
摘要： A new antitumor agent named macracidmycin, which is a macromolecular peptide and inhibits the growth of various tumor cells and experimental animal tumors such as Ehrlich ascites carcinoma and Sarcoma 180 is produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces atrofaciens (M590-G2 and A.T.C.C. 31104); it is recovered from the broth by conventional methods for recovering antibiotics.
摘要翻译： 通过发酵属于链霉菌属（Streptomyces）属的链霉菌属（Streptomyces）属的链霉菌属（Streptomyces）的发酵产生了称为macracidmycin的新型抗肿瘤剂，其是大分子肽，抑制各种肿瘤细胞的生长和实验动物肿瘤如Ehrlich腹水癌和肉瘤180 致病杆菌（M590-G2和ATCC 31104）; 通过用于回收抗生素的常规方法从肉汤中回收。
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公开(公告)号：US4147778A
公开(公告)日：1979-04-03
申请号：US797201
申请日：1977-05-16
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号： C12P1/06 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465 , A61K31/71 , C07H15/24
CPC分类号： C12R1/465 , C07H15/252 , C12P19/56 , Y10S435/886
摘要： A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
摘要翻译： 本文称为鲍曼霉素复合物的新型蒽环类抗生素复合物是通过发酵生产巴霉素的链霉菌菌株，例如， Streptomyces coeruleorubidus ME 130-A4（FERM-P3540，ATCC 31276）。 其中称为baumycin A1，A2，B1和B2的复合物和四种生物活性成分可用作抗细菌剂和抗肿瘤剂。
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14.发明授权Pharmacological compound with immunopotentiating activity and production and uses thereof 失效具有免疫增强活性的药理化合物及其制备及用途
公开(公告)号：US4238507A
公开(公告)日：1980-12-09
申请号：US21222
申请日：1979-03-16
申请人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Masaaki Ishizuka , Hajime Morishima , Ikuo Matsumoto , Takuzo Yamamoto
发明人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Masaaki Ishizuka , Hajime Morishima , Ikuo Matsumoto , Takuzo Yamamoto
IPC分类号： A61K31/195 , A61P37/00 , A61P37/04 , C07C51/00 , C07C65/01 , C07C67/00 , C07C227/00 , C07C227/02 , C07C227/18 , C07C227/20 , C07C227/26 , C07C229/36 , C07D317/46 , C07D319/08 , A01N37/12 , C07C101/72
CPC分类号： C07D319/08 , C07D317/46 , Y02P20/55
摘要： A new compound having the formula ##STR1## and now designated forphenicinol is produced, which exhibits an immunopotentiating activity. This new compound as well as its pharmaceutically acceptable salts and hydrates are useful for immunotherapy and treatment of immune diseases and disorders in living animals, including human beings. The new compound can be produced by hydrolysis of the corresponding aminonitrile compound of the formula ##STR2## or by reduction of forphenicine.
摘要翻译： 产生具有式“IMAGE”和现在指定为苯酚的新化合物，其具有免疫增强活性。 这种新化合物及其药学上可接受的盐和水合物可用于免疫治疗和治疗包括人在内的活的动物中的免疫疾病和病症。 新化合物可以通过水解相应的式“IMAGE”的氨基腈化合物或通过还原吩噻嗪来制备。
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15.发明授权
公开(公告)号：US4335250A
公开(公告)日：1982-06-15
申请号：US57014
申请日：1979-07-12
申请人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Masaaki Ishizuka , Hajime Morishima , Takuzo Yamamoto , Junji Yoshizawa , Masaaki Hosoi , Ikuo Matsumoto
发明人： Hamao Umezawa , Tomio Takeuchi , Takaaki Aoyagi , Masaaki Ishizuka , Hajime Morishima , Takuzo Yamamoto , Junji Yoshizawa , Masaaki Hosoi , Ikuo Matsumoto
IPC分类号： C07C69/88 , A61K31/19 , A61K31/235 , A61P37/04 , C07C51/00 , C07C51/09 , C07C65/01 , C07C65/03 , C07C67/00 , C07C69/84
CPC分类号： C07C65/03 , C07C65/01 , Y10S514/885
摘要： A new compound is produced which has the general formula: ##STR1## wherein R represents hydrogen atom or a lower alkyl group and which exhibits an immunopotentiating activity. This new compound as well as its pharmaceutically acceptable salts and hydrates are useful for immunotherapy and treatment of immune diseases and disorders in living animals including human beings. The new compound can be produced by reduction of a hydroxyterephthalic acid alkyl ester or by esterification of the corresponding 3-hydroxy-4-(hydroxymethyl)-benzoic acid.
摘要翻译： 制备了具有以下通式的新化合物：其中R表示氢原子或低级烷基，并表现出免疫增强活性。 该新化合物及其药学上可接受的盐和水合物可用于免疫治疗和治疗包括人在内的活动物中的免疫疾病和病症。 新化合物可以通过还原羟基对苯二甲酸烷基酯或通过相应的3-羟基-4-（羟甲基） - 苯甲酸的酯化来制备。
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公开(公告)号：US4851446A
公开(公告)日：1989-07-25
申请号：US022409
申请日：1987-03-06
申请人： Hamao Umezawa, deceased , Tomio Takeuchi , Masaaki Ishizuka , Fuminori Abe , Akio Fujii , Teruya Nakamura
发明人： Hamao Umezawa, deceased , Tomio Takeuchi , Masaaki Ishizuka , Fuminori Abe , Akio Fujii , Teruya Nakamura
IPC分类号： A61K31/16 , A61K31/165 , C07C279/18
CPC分类号： A61K31/165 , A61K31/16 , C07C279/18 , Y10S514/885
摘要： The present invention relates to an immunosuppressing method which comprises administering a spergualin-related compound represented by the following formula ##STR1## (wherein R.sub.1 is --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.6 --, ##STR2## R.sub.2 is --(CH.sub.2).sub.2 -- or --CH.dbd.CH--; and R.sub.3 is ##STR3## or pharmacologically acceptable salts thereof in an effective amount to a warm-blood animal.
摘要翻译： 本发明涉及一种免疫抑制方法，其包括给予由下式表示的精神药蛋白相关化合物+ TR NH（CH 2）3 NH（其中R 1为 - （CH 2）4 - ， - （CH 2） 对于温血动物，R 2是有效量的 - （CH 2）2 - 或-CH = CH-;且R 3是或其药学上可接受的盐。
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公开(公告)号：US4259319A
公开(公告)日：1981-03-31
申请号：US936835
申请日：1978-08-25
申请人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka , Kiyoshi Watanabe , Toshiaki Yamashita , Noriyuki Naoi , Takayoshi Hidaka
发明人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka , Kiyoshi Watanabe , Toshiaki Yamashita , Noriyuki Naoi , Takayoshi Hidaka
CPC分类号： C12P1/06
摘要： A new antibiotic designated as auromomycin is prepared from the culture broth of Streptomyces macromomyceticus, a macromomycin-producing strain, as yellow crystals. Auromomycin is recovered in pure form from the culture broth by using hydrophobic chromatography with Octyl Sephalose CL-4B or Phenyl Sepharose CL-4B.
摘要翻译： 从黄曲霉大麻霉菌（Streptomyces macromomyceticus）的培养液中制备一种新的抗生素，称为黄霉素，为黄色晶体。 通过使用具有辛基海藻糖CL-4B或苯基琼脂糖CL-4B的疏水层析从培养液中回收Auromomycin。
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18.发明授权Method for suppressing a transplantation immunity and treating an allergic disease and an autoimmune disease 失效抑制移植免疫和治疗过敏性疾病和自身免疫性疾病的方法
公开(公告)号：US4778824A
公开(公告)日：1988-10-18
申请号：US65613
申请日：1987-06-30
申请人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka , Fuminori Abe , Akio Fujii , Teruya Nakamura
发明人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka , Fuminori Abe , Akio Fujii , Teruya Nakamura
CPC分类号： A61K31/16 , Y10S514/885
摘要： This invention relates to method for suppressing a transplantation immunity and treating an allergic disease and an autoimmune disease in a mammal which comprises administering spergualin or a pharmaceutically acceptable salt thereof in effective amount to the said mammal.
摘要翻译： 本发明涉及抑制哺乳动物的移植免疫和治疗过敏性疾病和自身免疫性疾病的方法，其包括以有效量向所述哺乳动物施用精神分裂剂或其药学上可接受的盐。
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19.发明授权
公开(公告)号：US4219622A
公开(公告)日：1980-08-26
申请号：US17525
申请日：1979-03-05
申请人： Hamao Umezawa , Tomio Takeuchi , Hiroshi Naganawa , Masaaki Ishizuka , Norio Shibamoto , Toshikazu Oki , Taiji Inui
发明人： Hamao Umezawa , Tomio Takeuchi , Hiroshi Naganawa , Masaaki Ishizuka , Norio Shibamoto , Toshikazu Oki , Taiji Inui
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56
CPC分类号： C12R1/465 , C07H15/252 , C12P19/56 , C12R1/48 , Y10S435/886 , Y10S435/888
摘要： New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
摘要翻译： 称为MA 144-M1和MA 144-M2的新型抗肿瘤剂，其为蒽环类苷并抑制革兰氏阳性细菌的生长，例如， 金黄色葡萄球菌，枯草芽孢杆菌和黄褐斑，并且抑制动物肿瘤如白血病L 1210，P 388和肉瘤180的生长是通过发酵生产链霉菌的MA 144产生的菌株和通过化学或酶促转化阿拉霉素A或 赛琳布A.
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公开(公告)号：US4559362A
公开(公告)日：1985-12-17
申请号：US550184
申请日：1983-11-09
申请人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka
发明人： Hamao Umezawa , Tomio Takeuchi , Masaaki Ishizuka
IPC分类号： C12P21/00 , A61K31/13 , A61K31/132 , A61P43/00
CPC分类号： A61K31/13 , Y10S514/885
摘要： This invention relates to an immunopotentiator or an immunopotentiating method using spermidine or its pharmacologically acceptable salt as an active ingredient.
摘要翻译： 本发明涉及使用亚精胺或其药理学上可接受的盐作为活性成分的免疫增强剂或免疫增强方法。
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