-
公开(公告)号:US3992524A
公开(公告)日:1976-11-16
申请号:US555011
申请日:1975-03-03
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Akira Takamatsu , Toshikazu Oki , Hiroshi Tone
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Akira Takamatsu , Toshikazu Oki , Hiroshi Tone
CPC分类号: A61K36/06 , C07G11/00 , Y10S435/886
摘要: A new antitumor agent named macracidmycin, which is a macromolecular peptide and inhibits the growth of various tumor cells and experimental animal tumors such as Ehrlich ascites carcinoma and Sarcoma 180 is produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces atrofaciens (M590-G2 and A.T.C.C. 31104); it is recovered from the broth by conventional methods for recovering antibiotics.
摘要翻译: 通过发酵属于链霉菌属(Streptomyces)属的链霉菌属(Streptomyces)属的链霉菌属(Streptomyces)的发酵产生了称为macracidmycin的新型抗肿瘤剂,其是大分子肽,抑制各种肿瘤细胞的生长和实验动物肿瘤如Ehrlich腹水癌和肉瘤180 致病杆菌(M590-G2和ATCC 31104); 通过用于回收抗生素的常规方法从肉汤中回收。
-
公开(公告)号:US4192915A
公开(公告)日:1980-03-11
申请号:US898065
申请日:1978-04-20
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号: C07H15/252 , C12P19/56 , C12D9/14
CPC分类号: C12R1/465 , C07H15/252 , C12P19/56 , C12R1/48 , Y10S435/886 , Y10S435/888
摘要: New antitumor agents designated rhodirubin A and B, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria and mammalian tumors, are produced by fermentation of rhodirubin-producing strains of Streptomyces, e.g. Streptomyces sp. ME 505-HEI (ATCC 31273).
摘要翻译: 通过发酵罗丹明生产菌株Streptomyces,例如,通过发酵来产生称为罗丹霉素A和B的新型抗肿瘤药物,其是蒽环类苷并抑制革兰氏阳性细菌和哺乳动物肿瘤的生长。 链霉菌属 ME 505-HEI(ATCC 31273)。
-
公开(公告)号:US4127714A
公开(公告)日:1978-11-28
申请号:US823052
申请日:1977-08-09
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号: C12P19/56 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07H15/252 , C07H15/24
CPC分类号: C07H15/252 , Y10S435/886
摘要: New antitumor agents designated rhodirubin A and B, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria and mammalian tumors, are produced by fermentation of rhodirubin-producing strains of Streptomyces, e.g. Streptomyces sp. ME 505-HEI (ATCC 31273).
摘要翻译: 通过发酵罗丹明生产菌株Streptomyces,例如,通过发酵来产生称为罗丹霉素A和B的新型抗肿瘤药物,其是蒽环类苷并抑制革兰氏阳性细菌和哺乳动物肿瘤的生长。 链霉菌属 ME 505-HEI(ATCC 31273)。
-
4.
公开(公告)号:US4198480A
公开(公告)日:1980-04-15
申请号:US886987
申请日:1978-03-15
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号: C12P1/06 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465
CPC分类号: C12R1/465 , C07H15/252 , C12P19/56 , Y10S435/886
摘要: A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
摘要翻译: 本文称为鲍曼霉素复合物的新型蒽环类抗生素复合物是通过发酵生产巴霉素的链霉菌菌株,例如, Streptomyces coeruleorubidus ME 130-A4(FERM-P3540,ATCC 31276)。 其中称为baumycin A1,A2,B1和B2的复合物和四种生物活性成分可用作抗细菌剂和抗肿瘤剂。
-
公开(公告)号:US4147778A
公开(公告)日:1979-04-03
申请号:US797201
申请日:1977-05-16
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号: C12P1/06 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465 , A61K31/71 , C07H15/24
CPC分类号: C12R1/465 , C07H15/252 , C12P19/56 , Y10S435/886
摘要: A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
摘要翻译: 本文称为鲍曼霉素复合物的新型蒽环类抗生素复合物是通过发酵生产巴霉素的链霉菌菌株,例如, Streptomyces coeruleorubidus ME 130-A4(FERM-P3540,ATCC 31276)。 其中称为baumycin A1,A2,B1和B2的复合物和四种生物活性成分可用作抗细菌剂和抗肿瘤剂。
-
公开(公告)号:US4049497A
公开(公告)日:1977-09-20
申请号:US747470
申请日:1976-12-06
申请人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka , Hiroshi Naganawa
发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka , Hiroshi Naganawa
IPC分类号: C07G11/00
CPC分类号: A61K36/06 , C07G11/00 , Y10S435/886
摘要: There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).
摘要翻译: 已经公开了两种以前称为MC916-A和MC916-B的新抗生素,现在称为新西霉素A和新霉素B,其是白血病细胞生长的有效抑制剂,例如。 白血病L-1210细胞在小鼠中。 它们通过Frep-P 2452链霉菌(A.T.C.C. 31123)的对照发酵生产。
-
公开(公告)号:US4358602A
公开(公告)日:1982-11-09
申请号:US240457
申请日:1981-03-04
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Shinichi Kondo , Masaaki Ishizuka
IPC分类号: A61K31/335 , A61K31/337 , A61K31/365 , A61P37/04 , C07D305/12 , C12N9/99 , C12P17/02 , C12R1/465
CPC分类号: C12R1/465 , C07D305/12 , C12P17/02
摘要: New physiologically active substances, ebelactone A and ebelactone B which are generally termed ebelactone are produced from a new microorganism, Streptomyces MG7-G1 strain identified FERM-P 5363 or ATCC No. 31860 and ATCC No. 31880. Ebelactone is useful as a host defense stimulator having an activity to enhance cell-mediated immunity, and also as an anti-inflammatory agent.
摘要翻译: 通常称为内酯的新的生理活性物质Ebelactone A和ebelactone B由新的微生物,鉴定为FERM-P 5363的链霉菌MG7-G1菌株或ATCC No.31860和ATCC No.31880产生.Ebelactone可用作宿主防御 刺激剂具有增强细胞介导的免疫力的活性,并且还作为抗炎剂。
-
8.
公开(公告)号:US4859593A
公开(公告)日:1989-08-22
申请号:US809215
申请日:1985-12-16
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
CPC分类号: C12P13/005 , C07C279/12 , C12R1/01 , Y10S435/822
摘要: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.
-
公开(公告)号:US4663342A
公开(公告)日:1987-05-05
申请号:US749456
申请日:1985-06-27
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号: C07D207/08 , A61K31/40 , A61K38/00 , A61P37/04
CPC分类号: A61K31/40
摘要: A compound of the formula (I) ##STR1## which is identified as an actinonin has now been found to potentiate the immune response in animals bearing Ascites Sarcoma 180 tumor cells.
摘要翻译: 现已发现被鉴定为放线诺宁的式(I)化合物(I)可增强携带腹水肉瘤180肿瘤细胞的动物的免疫应答。
-
公开(公告)号:US4242453A
公开(公告)日:1980-12-30
申请号:US39094
申请日:1979-05-14
申请人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人: Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号: A61K31/335 , A61K31/337 , A61K38/55 , A61P37/06 , C07D305/12 , C07G99/00 , C12N9/99 , C12P1/06 , C12P13/00 , C12P17/02 , C12R1/465
CPC分类号: C07D305/12 , C12P17/02 , Y10S435/899
摘要: A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##
摘要翻译: 现在提供一种名为酯酶的新的生理活性物质,其抑制酯酶的活性,并且可用作免疫抑制药物。 通过培养鉴定为FERM-P 3723或ATCC的微生物链霉菌属MD4-C1产生甾类化合物。 31336在有氧条件下在培养基中,并从所得培养物中回收。 甾类化合物是具有式CH 3(CH 2)4 CHCHCH 2 CH + TR
的化合物
-
-
-
-
-
-
-
-
-