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11.发明申请公开(公告)号：US20250145632A1
公开(公告)日：2025-05-08
申请号：US18721125
申请日：2022-12-21
Applicant: INSILICO MEDICINE IP LIMITED
Inventor： Hongfu LU , Jingjing PENG , Xiao DING , Jinxin LIU , Yingtao LIU , Feng REN , Fusheng ZHOU , Tao JIANG , Tao LIANG , Jiong LAN , Qiang LU
IPC: C07D487/22 , A61K31/519 , A61K31/675 , A61P35/00 , C07D471/22 , C07D487/16 , C07D498/16 , C07D498/22 , C07D519/00 , C07F9/6561
Abstract: The present invention discloses a pyrimidine heterocyclic compound, and a preparation method and medical use thereof. Specifically, the present invention discloses a pyrimidine heterocyclic compound with a structure shown in Formula (A) or a pharmaceutically acceptable salt thereof (groups are each defined in the specification), a pharmaceutical composition comprising the compound, and use of the compound in treatment of cell proliferative diseases (such as cancers).
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公开(公告)号：US20250034132A1
公开(公告)日：2025-01-30
申请号：US18704366
申请日：2022-10-28
Applicant: Insilico Medicine IP Limited
IPC: C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/5377
Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.
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公开(公告)号：US20240132465A1
公开(公告)日：2024-04-25
申请号：US18509658
申请日：2023-11-15
Applicant: Insilico Medicine IP Limited
Inventor： Chiachun CHEN , Xiao DING , Xiaosong LIU , Feng REN , Hailong WANG
IPC: C07D401/04 , C07D239/95 , C07D403/04 , C07D471/04 , C07D487/04
CPC classification number: C07D401/04 , C07D239/95 , C07D403/04 , C07D471/04 , C07D487/04
Abstract: Described herein are MAT2A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with MAT2A.
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公开(公告)号：US20240109880A1
公开(公告)日：2024-04-04
申请号：US18486369
申请日：2023-10-13
Applicant: Insilico Medicine IP Limited
Inventor： Xin CHENG , Luoheng QIN , Feng REN
IPC: C07D413/14 , C07D498/04 , C07D413/06 , C07D413/12 , C07D417/14 , C07D417/12 , C07D417/06
CPC classification number: C07D413/14 , C07D498/04 , C07D413/06 , C07D413/12 , C07D417/14 , C07D417/12 , C07D417/06
Abstract: Described herein are KAT6A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KAT6A.
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公开(公告)号：US20230192624A1
公开(公告)日：2023-06-22
申请号：US18107127
申请日：2023-02-08
Applicant: Insilico Medicine IP Limited
Inventor： Xiao DING , Jingjing PENG , Feng REN , Xiaoyu DING , Bogdan ZAGRIBELNYY , Yan A. IVANENKOV
IPC: C07D233/96 , A61P31/14
CPC classification number: C07D233/96 , A61P31/14
Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.
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Patent Agency Ranking
公开(公告)号：US20250101019A1
公开(公告)日：2025-03-27
申请号：US18832564
申请日：2023-01-28
Applicant: Insilico Medicine IP Limited
Inventor： Xin CHENG , Yingtao LIU , Luoheng QIN , Feng REN , Huaxing YU
IPC: C07D471/04 , A61K31/437 , A61K31/444
Abstract: Described herein are ENPP1 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with ENPP1.
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公开(公告)号：US20250042890A1
公开(公告)日：2025-02-06
申请号：US18702772
申请日：2022-10-19
Applicant: Insilico Medicine IP Limited
Inventor： Chiachun CHEN , Xiao DING , Xiaosong LIU , Qinguan MENG , Feng REN , Hailong WANG
IPC: C07D413/14 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/95 , C07D401/04 , C07D403/04 , C07D471/04 , C07D487/04
Abstract: Described herein are MAT2A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with MAT2A.
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公开(公告)号：US20240116935A1
公开(公告)日：2024-04-11
申请号：US18507595
申请日：2023-11-13
Applicant: Insilico Medicine IP Limited
Inventor： Hongfu LU , Huaxing YU , Xiao DING , Feng REN
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Described herein are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.
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公开(公告)号：US20240051958A1
公开(公告)日：2024-02-15
申请号：US18486374
申请日：2023-10-13
Applicant: Insilico Medicine IP Limited
Inventor： Hongfu LU , Huaxing YU , Xiao DING , Feng REN
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Described herein are DGKalpha inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with DGKalpha.
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公开(公告)号：US20240025860A1
公开(公告)日：2024-01-25
申请号：US18339366
申请日：2023-06-22
Applicant: Insilico Medicine IP Limited
Inventor： Xiao DING , Jingjing PENG , Feng REN , Xiaoyu DING , Bogdan ZAGRIBELNYY , Yan A. IVANENKOV
IPC: C07D233/96 , A61P31/14
CPC classification number: C07D233/96 , A61P31/14
Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.
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