公开(公告)号：US20200085779A1

公开(公告)日：2020-03-19

申请号：US16472084

申请日：2017-12-22

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Ralf Warrass ,  Joachim Ullrich ,  Michael Berger ,  Michael Linder

IPC: A61K31/27 ,  A61K31/695 ,  A61K31/166 ,  A61P31/04 ,  A61P11/00 ,  A61K9/00 ,  A61K31/357 ,  A61K31/5377 ,  A61K31/222 ,  A61K31/495 ,  A61K31/40 ,  A61K31/445 ,  A61K31/54 ,  A61K31/472

Abstract: The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20210347730A1

公开(公告)日：2021-11-11

申请号：US17253437

申请日：2019-06-24

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Michael Berger ,  Ralf Warrass ,  Joachim Ullrich

IPC: C07C259/06 ,  A61P31/04

Abstract: The present invention provides compounds of formula (I) for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20210292284A1

公开(公告)日：2021-09-23

申请号：US17253346

申请日：2019-06-24

Applicant: Intervet Inc.

Inventor： Thorsten Meyer ,  Michael Berger ,  Ralf Warrass ,  Joachim Ullrich

IPC: C07D239/94 ,  A61P31/04 ,  C07D217/22 ,  C07D275/04

Abstract: The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD)

公开(公告)号：US09260441B2

公开(公告)日：2016-02-16

申请号：US14387437

申请日：2013-03-27

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Marko Eck ,  Christopher Kern

IPC: A61K31/497 ,  C07D401/00 ,  C07D487/08 ,  C07D213/74 ,  C07D213/82 ,  C07D213/85 ,  C07D213/89 ,  C07D215/38 ,  C07D401/04 ,  C07D401/12 ,  C07D239/42 ,  C07D271/113 ,  C07D277/42 ,  C07D277/56 ,  C07D271/07 ,  C07D277/46

CPC classification number: C07D487/08 ,  C07D213/74 ,  C07D213/82 ,  C07D213/85 ,  C07D213/89 ,  C07D215/38 ,  C07D239/42 ,  C07D271/07 ,  C07D271/113 ,  C07D277/42 ,  C07D277/46 ,  C07D277/56 ,  C07D401/04 ,  C07D401/12

Abstract: This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth infections and the treatment of parasitosis caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to pharmaceutical compositions and kits comprising the compounds.

Abstract translation: 本发明涉及用作药物的某些杂芳基化合物，更具体地涉及用于治疗动物的药物。 药物可用于治疗蠕虫感染和治疗由蠕虫感染引起的寄生虫病。 本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。 本发明还涉及包含该化合物的药物组合物和试剂盒。

公开(公告)号：US12077488B2

公开(公告)日：2024-09-03

申请号：US17316034

申请日：2021-05-10

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Thorsten Meyer ,  Joachim Ullrich ,  Ralf Warrass

IPC: A61K31/165 ,  A61P11/00 ,  A61P31/04 ,  C07C259/06 ,  C07C317/50 ,  C07C323/60 ,  C07D205/04 ,  C07D207/14 ,  C07D213/56 ,  C07D217/18 ,  C07D233/64 ,  C07D235/14 ,  C07D259/00 ,  C07D267/10 ,  C07D277/28 ,  C07D295/00 ,  C07D295/155 ,  C07D307/52 ,  C07D307/56 ,  C07D317/50 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07C259/06 ,  A61P11/00 ,  A61P31/04 ,  C07C317/50 ,  C07C323/60 ,  C07D213/56 ,  C07D217/18 ,  C07D235/14 ,  C07D267/10 ,  C07D277/28 ,  C07D295/155 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16

Abstract: The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

公开(公告)号：US20240043385A1

公开(公告)日：2024-02-08

申请号：US18256094

申请日：2021-12-10

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Michael Linder ,  Carolin Schneider ,  Janina Tänzler ,  Ulrich Sondern

IPC: C07D213/71 ,  C07D413/14 ,  A61P33/10

CPC classification number: C07D213/71 ,  C07D413/14 ,  A61P33/10

Abstract: The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.

公开(公告)号：US20230148316A1

公开(公告)日：2023-05-11

申请号：US17785656

申请日：2020-12-17

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Michael R. Linder ,  Carolin Schneider ,  Janina Tanzler ,  Ulrich Sondern

IPC: C07D405/12 ,  C07D215/38 ,  A61P33/10

CPC classification number: C07D405/12 ,  C07D215/38 ,  A61P33/10

Abstract: The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.

公开(公告)号：US20230110397A1

公开(公告)日：2023-04-13

申请号：US17785646

申请日：2020-12-17

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Michael R. Linder ,  Carolin Schneider ,  Janina Tanzler ,  Ulrich Sondern

IPC: C07D471/04 ,  A61P33/10 ,  A01N43/90 ,  A01P5/00

Abstract: The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.

公开(公告)号：US10562834B2

公开(公告)日：2020-02-18

申请号：US16240271

申请日：2019-01-04

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Stephan Veit ,  Hans Peter Niedermann ,  Tobias Kappesser ,  Alfred Stutz

IPC: C07C51/09 ,  C07C67/31 ,  C07C67/327 ,  C07C67/343 ,  C07C67/30 ,  C07C67/313

Abstract: A process to prepare a compound of Formula (I) wherein R3, R4 and R5 are each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

公开(公告)号：US20190352256A1

公开(公告)日：2019-11-21

申请号：US16472001

申请日：2017-12-22

Applicant: Intervet Inc.

Inventor： Michael Berger ,  Thorsten Meyer ,  Joachim Ullrich ,  Ralf Warrass

IPC: C07C259/06 ,  A61P31/04 ,  C07D277/28 ,  C07D213/56 ,  C07D333/20 ,  C07D307/52 ,  C07D217/18 ,  C07D295/155 ,  C07D417/12 ,  C07D409/12 ,  C07D405/12 ,  C07D235/14 ,  C07D267/10 ,  C07D413/12 ,  C07C323/60 ,  C07C317/50 ,  A61P11/00

Abstract: The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).