公开(公告)号：US09909084B2

公开(公告)日：2018-03-06

申请号：US14235293

申请日：2012-07-30

Applicant: Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

Inventor： Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

IPC: C07C29/86 ,  C11B13/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/06 ,  A61K8/97 ,  A61K8/99 ,  C11B1/04 ,  C11B1/10 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15

CPC classification number: C11B13/00 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15 ,  A61K8/97 ,  A61K8/99 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/04 ,  C11B1/10

Abstract: The present invention relates to an extraction process of an unsaponifiable fraction contained in an oil or a vegetable butter, in an oil originating from a micro-organism, in a concentrate of oil or butter or of oil originating from a micro-organism, or in a co-product of the refining industry for vegetable oils, such as deodorization exhaust and distillates of physical refining, or oils originating from micro-organisms, comprising at least: A) a transformation step of said oils, of said butter or said co-product of the refining industry for vegetable oils or oils originating from micro-organisms in hydro-alcoholic solution, especially via a saponification step, and B) an extraction step of the hydro-alcoholic solution in which the fatty fraction is separated from unsaponifiable fraction by liquid/liquid extraction, said process being characterized in that at least the liquid/liquid extraction step of the step B is performed by using a first solvent system comprising a solvent content selected from the solvents comprising at least 5 carbon atoms and one or two oxygen atoms in the form of either ether function, or ketone function, or ester function, of at least 50% in volume relative to the total volume of the first solvent system, as well as fractions obtained by said process.

公开(公告)号：US09447361B2

公开(公告)日：2016-09-20

申请号：US13823573

申请日：2012-01-31

Applicant: Jacques Legrand ,  Alex Saunois ,  Caroline Baudouin ,  Philippe Msika

Inventor： Jacques Legrand ,  Alex Saunois ,  Caroline Baudouin ,  Philippe Msika

IPC: C11B3/14 ,  A61K8/63 ,  A61K8/67 ,  C07D311/72 ,  A61K8/31 ,  A61Q19/06 ,  A61Q19/08 ,  A61K8/97 ,  A61K31/20 ,  A61K31/355 ,  A61K31/56 ,  C11B3/00 ,  C11C3/00

CPC classification number: C11B3/14 ,  A61K8/31 ,  A61K8/63 ,  A61K8/678 ,  A61K8/97 ,  A61K31/20 ,  A61K31/355 ,  A61K31/56 ,  A61Q19/06 ,  A61Q19/08 ,  C07D311/72 ,  C11B3/00 ,  C11C3/003

Abstract: The present invention relates to the use of at least one vegetable oil refining industry by-product to obtain a purified total unsaponifiable of vegetable oil cleared of the impurities initially present in the said by-product, advantageously cleared of sapid and odorous compounds and/or chemical compounds resulting from the deterioration and the degradation of vegetable oils. The invention further relates to a method for obtaining a purified total unsaponifiable of vegetable oil from at least one vegetable oil refining industry by-product. The invention further relates to a purified total unsaponifiable of vegetable oil able to be obtained by this method, as well as compositions containing such an unsaponifiable. The invention further relates to such unsaponifiables or such compositions for the use thereof as a drug, medical device, dermatological agent, cosmetic agent or nutraceutical, in humans or animals.

Abstract translation: 本发明涉及使用至少一种植物油精炼工业副产物以获得纯化的总不能皂化的植物油，其清除最初存在于所述副产物中的杂质，有利地清除了无色和无色的化合物和/或 由植物油的劣化和降解引起的化合物。 本发明还涉及从至少一种植物油精炼工业副产品获得纯化的不可皂化植物油的纯化方法。 本发明还涉及能够通过该方法获得的纯化的总不皂化的植物油，以及含有这种不皂化的组合物。 本发明还涉及这种不可皂化物或其用于人或动物中作为药物，医疗装置，皮肤病学药剂，化妆品或营养药物的组合物。

公开(公告)号：US09133415B2

公开(公告)日：2015-09-15

申请号：US14235284

申请日：2012-07-30

Applicant: Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

Inventor： Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

IPC: C11B1/00 ,  C12P3/00 ,  C11B1/10 ,  A23L1/30 ,  A23L1/302 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q19/06 ,  A61K8/97 ,  A61K8/99 ,  C11B9/02 ,  C11B1/04 ,  A23D9/00 ,  A61K36/48 ,  A61K36/54

CPC classification number: C11B1/10 ,  A23D9/00 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15 ,  A61K8/97 ,  A61K8/99 ,  A61K36/48 ,  A61K36/54 ,  A61K2236/00 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/04 ,  C11B9/025

Abstract: The present invention relates to a process for the solid/liquid extraction of a natural extract contained in at least one vegetable solid or micro-organism comprising at least the following steps: solid/liquid extraction of at least one vegetable solid or micro-organism by a first solvent system comprising a solvent content chosen from the solvents comprising between 5 and 8 carbon atoms and one or two oxygen atoms in ether function, or ketone function, or ester function form, of at least 50% by volume in relation to the total volume of the first solvent system, retrieval of a natural extract, notably comprising or consisting of an oil or a butter, particularly enriched with unsaponifiable.

Abstract translation: 本发明涉及固体/液体提取至少一种植物固体或微生物中含有的天然提取物的方法，该方法至少包括以下步骤：至少一种植物固体或微生物的固/液萃取 第一溶剂系统，其包含溶剂含量，所述溶剂含量选自包含5-8个碳原子和一个或两个乙醚官能团的氧原子，或酮官能团或酯官能团形式的至少50体积％ 第一溶剂系统的体积，天然提取物的回收，特别是包含或由油或黄油组成，特别是富含不皂化物。

公开(公告)号：US20120294887A1

公开(公告)日：2012-11-22

申请号：US13575404

申请日：2011-01-31

Applicant: Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

Inventor： Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

IPC: C11B1/10 ,  A61K36/05 ,  A61K8/97 ,  A61K8/99 ,  A23D9/00 ,  A61P19/04 ,  A61P19/02 ,  A61P1/02 ,  A61P17/00 ,  A61Q19/00 ,  A61K36/54 ,  C07C27/02

CPC classification number: A61Q19/00 ,  A23L33/10 ,  A23L33/105 ,  A23L33/115 ,  A61K8/922 ,  A61K8/97 ,  C11B1/10 ,  C11C1/025 ,  C11C3/003

Abstract: The invention relates to a method for the solid/liquid extraction of an oil or butter, particularly having a high unsaponifiable content, contained in at least one solid vegetable matter or a micro-organism. The method includes at least the following steps: solid/liquid extraction of at least one solid vegetable matter or a micro-organism using a first solvent system comprising a concentration of solvent selected from among fluorinated aromatic solvents, particularly trifluorotoluene (BTF) and hexafluorobenzene (BHF), tert-butyl ethers, particularly 2-ethoxy-2-methylpropane, also known as ethyl-tert-butyl-ether (ETBE), and 2-methoxy-2-methylpropane or methyl-tert-butylether (MTBE), solvents comprising at least one silicon atom, particularly hexamethyldisiloxane (HMDS) and tetramethylsilane (TMS), methyl-tetrahydrofuran (MeTHF), and mixtures thereof, representing at least 50 vol.-% in relation to the total volume of the solvent system; and, optionally, recovery of a fraction comprising the oil or butter, particularly unsaponifiable enriched. The invention also relates to an unsaponifiable fraction, oil or butter obtained using this method and to compositions containing said oil or fraction.

Abstract translation: 本发明涉及用于固体/液体提取包含在至少一种固体植物物质或微生物中的油或黄油，特别是具有高不皂化含量的方法。 该方法至少包括以下步骤：使用第一溶剂系统固体/液体萃取至少一种固体植物物质或微生物，所述第一溶剂系统包含选自氟化芳族溶剂，特别是三氟甲苯（BTF）和六氟苯（ BHF），叔丁基醚，特别是2-乙氧基-2-甲基丙烷，也称为乙基叔丁基醚（ETBE）和2-甲氧基-2-甲基丙烷或甲基叔丁基醚（MTBE），溶剂 包括至少一个硅原子，特别是六甲基二硅氧烷（HMDS）和四甲基硅烷（TMS），甲基 - 四氢呋喃（MeTHF）及其混合物，相对于溶剂体系的总体积为至少50vol。 并且任选地回收包含油或黄油的馏分，特别是不皂化的富集物。 本发明还涉及使用该方法获得的不皂化的馏分，油或黄油以及含有所述油或馏分的组合物。

公开(公告)号：US07371420B2

公开(公告)日：2008-05-13

申请号：US10522907

申请日：2003-07-28

Applicant: Antoine Piccirilli ,  Jacques Legrand

Inventor： Antoine Piccirilli ,  Jacques Legrand

IPC: A61K35/78

CPC classification number: C11B1/06 ,  A23L33/105 ,  A61K36/54 ,  C11B1/04 ,  C11B1/10 ,  C11B3/12

Abstract: The present invention relates to a process for obtaining a furan lipid-rich unsaponifiable material from avocado, which comprises the successive steps (1) of controlled dehydration of fresh avocados or of avocados that have undergone preliminary transformations, (2) of extraction of the oil from dehydrated fruit, (3) of a heat treatment of the extracted oil and of a step of concentration of the unsaponifiable fraction of the oil or alternately, these two operations possibly being carried out successively in this order or in the reverse order, and finally (4) a step of saponification and of extraction of the unsaponifiable material.

Abstract translation: 本发明涉及一种从鳄梨中获得富含呋喃富含脂肪的不可皂化物质的方法，该方法包括以下步骤（1）：经过初步转化的新鲜鳄梨或鳄梨的受控脱水步骤（1），（2）提取油 脱水果，（3）提取油的热处理和不皂化部分浓缩的步骤，或者这两个操作可能依次顺序或以相反的顺序进行，最后 （4）皂化和提取不皂化物质的步骤。

公开(公告)号：US06582688B1

公开(公告)日：2003-06-24

申请号：US10088077

申请日：2002-03-20

Applicant: Nicole Broutin ,  Jacques Legrand ,  Antoine Piccirilli

Inventor： Nicole Broutin ,  Jacques Legrand ,  Antoine Piccirilli

IPC: A01N6500

CPC classification number: A61Q19/08 ,  A23L33/105 ,  A23L33/115 ,  A61K8/922 ,  A61K8/97 ,  A61Q19/00 ,  C07C29/80 ,  C07D307/36 ,  C07C33/02

Abstract: The invention concerns a method for selectively extracting furan lipids and polyhydroxylated fatty alcohols of avocado, characterised in that it comprises steps which consist in: preparing an unsaponifiable matter of avocado; then in subjecting the unsaponifiable matter of avocado to a step of molecular distillation using adjusted temperature and pressure means to obtain either a distillate comprising mainly furan lipids and polyhydroxylated fatty alcohols of avocado. Said method enables in particular to extract selectively furan lipids of avocado having a furan lipid content of more than 80 wt. %, even close to 98%.

Abstract translation: 本发明涉及一种用于选择性提取呋喃果糖的呋喃脂质和多羟基化脂肪醇的方法，其特征在于它包括以下步骤：制备不可皂化的鳄梨物质; 然后在使用调节的温度和压力的情况下将鳄梨的不皂化物质经受分子蒸馏的步骤，以获得主要包含呋喃油脂的呋喃油脂和鳄梨多羟基化脂肪醇的馏出物。 所述方法特别能够选择性地提取具有大于80重量％的呋喃脂质含量的鳄梨脂肪。 ％，甚至接近98％。

公开(公告)号：US4666226A

公开(公告)日：1987-05-19

申请号：US795073

申请日：1985-11-04

Applicant: Jacques Legrand ,  Jean C. Rouffy

Inventor： Jacques Legrand ,  Jean C. Rouffy

IPC: H01R12/71 ,  H01R13/22 ,  H01R43/00 ,  H05K3/32 ,  H05K7/10 ,  H01R9/09

CPC classification number: H01R43/007 ,  H01R12/714 ,  H01R13/22 ,  H05K7/1061 ,  Y10T29/4922

Abstract: A miniature small pitch connection element comprises an insulating elastomer body associated with conducting strips. The strips are disposed about the body over the largest part of its circumference and the remaining portion of the strips is overmolded by the body to be inside it to provide a strong mechanical connection between said strips and the body. The strips emerging from said body by their respective two ends.

Abstract translation: 微型小节距连接元件包括与导电带相关联的绝缘弹性体。 条带围绕主体设置在其圆周的最大部分上，并且条的剩余部分被主体包覆成型以在其内部，以在所述条和主体之间提供强大的机械连接。 从所述主体通过它们各自的两端出现的条。

公开(公告)号：US20140363559A1

公开(公告)日：2014-12-11

申请号：US14235293

申请日：2012-07-30

Applicant: Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

Inventor： Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

IPC: C11B13/00

CPC classification number: C11B13/00 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15 ,  A61K8/97 ,  A61K8/99 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/04 ,  C11B1/10

Abstract: The present invention relates to an extraction process of an unsaponifiable fraction contained in an oil or a vegetable butter, in an oil originating from a micro-organism, in a concentrate of oil or butter or of oil originating from a micro-organism, or in a co-product of the refining industry for vegetable oils, such as deodorisation exhaust and distillates of physical refining, or oils originating from micro-organisms, comprising at least: A) a transformation step of said oils, of said butter or said co-product of the refining industry for vegetable oils or oils originating from micro-organisms in hydro-alcoholic solution, especially via a saponification step, and B) an extraction step of the hydro-alcoholic solution in which the fatty fraction is separated from unsaponifiable fraction by liquid/liquid extraction, said process being characterised in that at least the liquid/liquid extraction step of the step B is performed by using a first solvent system comprising a solvent content selected from the solvents comprising at least 5 carbon atoms and one or two oxygen atoms in the form of either ether function, or ketone function, or ester function, of at least 50% in volume relative to the total volume of the first solvent system, as well as fractions obtained by said process.

Abstract translation: 本发明涉及包含在油或植物黄油中的不皂化成分的提取方法，来自微生物的油，油或黄油或源自微生物的油的浓缩物，或 炼油工业用于植物油的共同产品，例如除臭废气和物理精炼馏出物，或源于微生物的油，其至少包括：A）所述油的所述油或所述共混物的转化步骤， 特别是通过皂化步骤，特别是通过皂化步骤的来自微生物的植物油或油的精炼工业的产品，以及B）将所述脂肪馏分与不皂化部分分离的水醇溶液的提取步骤 液/液萃取，所述方法的特征在于，通过使用包含溶剂含量的第一溶剂体系，至少进行步骤B的液/液萃取步骤 选自包含至少5个碳原子和1或2个氧原子形式的醚功能或酮官能团或酯官能团的相对于第一溶剂体系的总体积至少为50体积％的氧原子， 以及通过所述方法获得的级分。

公开(公告)号：US20140171669A1

公开(公告)日：2014-06-19

申请号：US14235284

申请日：2012-07-30

Applicant: Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

Inventor： Eglantine Mercier ,  Jacques Legrand ,  Alex Saunois

IPC: C11B1/10

CPC classification number: C11B1/10 ,  A23D9/00 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15 ,  A61K8/97 ,  A61K8/99 ,  A61K36/48 ,  A61K36/54 ,  A61K2236/00 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/04 ,  C11B9/025

Abstract: The present invention relates to a process for the solid/liquid extraction of a natural extract contained in at least one vegetable solid or micro-organism comprising at least the following steps: solid/liquid extraction of at least one vegetable solid or micro-organism by a first solvent system comprising a solvent content chosen from the solvents comprising between 5 and 8 carbon atoms and one or two oxygen atoms in ether function, or ketone function, or ester function form, of at least 50% by volume in relation to the total volume of the first solvent system, retrieval of a natural extract, notably comprising or consisting of an oil or a butter, particularly enriched with unsaponifiable.

Abstract translation: 本发明涉及固体/液体提取至少一种植物固体或微生物中含有的天然提取物的方法，该方法至少包括以下步骤：至少一种植物固体或微生物的固/液萃取 第一溶剂系统，其包含溶剂含量，所述溶剂含量选自包含5-8个碳原子和一个或两个乙醚官能团的氧原子，或酮官能团或酯官能团形式的至少50体积％ 第一溶剂系统的体积，天然提取物的回收，特别是包含或由油或黄油组成，特别是富含不皂化物。

公开(公告)号：US08318186B2

公开(公告)日：2012-11-27

申请号：US10181370

申请日：2001-01-18

Applicant: Philippe Msika ,  Antoine Piccirilli ,  Jacques Legrand

Inventor： Philippe Msika ,  Antoine Piccirilli ,  Jacques Legrand

IPC: A61K8/02 ,  A61K8/00 ,  A61K9/20 ,  C12P7/64

CPC classification number: A61Q19/008 ,  A23K20/158 ,  A61K8/37 ,  A61K8/922 ,  A61K9/06 ,  A61K31/23 ,  A61K31/231 ,  A61K2800/782 ,  A61Q7/00 ,  A61Q7/02 ,  A61Q19/00

Abstract: The invention concerns the use of at least a fatty ester for preparing a composition designed to inhibit 5α-reductase activity. Said use produces a remarkable inhibiting effect of 5α-reductase thereby providing a novel response for treating dermatological pathologies and/or disorders related to congenital or acquired exaggeration of 5α-reductase activity, in particular for treating prostatic hypertrophy, prostatic adenoma, acne, hyperseborrhea, alopecia and hirsutism. The invention also concerns cosmetic treatment methods, in particular for greasy skin, and the use of said fatty esters as additives in a food product for human and/or animal consumption.

Abstract translation: 本发明涉及至少一种脂肪酯用于制备抑制5α-还原酶活性的组合物的用途。 所述用途产生了5α-还原酶的显着抑制作用，从而为治疗与先天性或后遗症5α-还原酶活性相关的皮肤病学病症和/或病症，特别是用于治疗前列腺肥大，前列腺腺瘤，痤疮，过度脂肪， 脱发和多毛症。 本发明还涉及化妆品处理方法，特别是油性皮肤，以及所述脂肪酯作为食品中添加剂用于人和/或动物消费的用途。