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公开(公告)号：US20110098797A1
公开(公告)日：2011-04-28
申请号：US12909609
申请日：2010-10-21
IPC分类号： A61K31/573 , A61K9/00 , A61P29/00 , A61N1/05
CPC分类号： A61N1/0568 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/608
摘要： The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.
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12.发明授权公开(公告)号：US09375515B2
公开(公告)日：2016-06-28
申请号：US12409790
申请日：2009-03-24
IPC分类号： A61K31/727 , A61L27/54 , A61L27/34 , A61F2/02
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/416 , Y10T428/31544 , C08L79/02
摘要： The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
摘要翻译： 本发明涉及固定化的生物活性物质，其在机械操作实体所固定的基底材料之后保持显着的生物学活性。
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13.发明授权Medical device capable of being compacted and expanded having anti-thrombin III binding activity 有权具有抗凝血酶III结合活性的能够被压实和扩增的医疗装置公开(公告)号：US08986713B2
公开(公告)日：2015-03-24
申请号：US11747163
申请日：2007-05-10
IPC分类号： A61K9/00 , A61F2/00 , C12Q1/00 , C12N11/00 , C12N11/02 , C12M1/00 , C08B37/10 , A61L27/54 , A61L27/34
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/416 , Y10T428/31544 , C08L79/02
摘要： The present invention relates to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
摘要翻译： 本发明涉及固定化的生物活性实体，其在机械操作实体所固定的基底材料之后保持显着的生物学活性。
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14.发明授权Immobilized biologically active entities having a high degree of biological activity 有权具有高度生物活性的固定生物活性物质公开(公告)号：US08691260B2
公开(公告)日：2014-04-08
申请号：US13208196
申请日：2011-08-11
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
摘要翻译： 本发明涉及具有肝素辅因子II结合活性的固定生物活性物质。
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公开(公告)号：US08409604B2
公开(公告)日：2013-04-02
申请号：US13208220
申请日：2011-08-11
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
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16.发明申请IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY 有权具有高度生物活性的固定生物活性物质公开(公告)号：US20120207791A1
公开(公告)日：2012-08-16
申请号：US13208196
申请日：2011-08-11
IPC分类号： A61K31/726 , A61K33/42 , A61P7/02 , A61K9/00 , A61K31/721
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
摘要翻译： 本发明涉及具有肝素辅因子II结合活性的固定生物活性物质。
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17.发明申请公开(公告)号：US20090181067A1
公开(公告)日：2009-07-16
申请号：US12409790
申请日：2009-03-24
IPC分类号： A61L27/54 , A61K31/727
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/416 , Y10T428/31544 , C08L79/02
摘要： The present invention is directed to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
摘要翻译： 本发明涉及固定化的生物活性物质，其在机械操作实体所固定的基底材料之后保持显着的生物学活性。
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18.发明授权公开(公告)号：US09114194B2
公开(公告)日：2015-08-25
申请号：US11433250
申请日：2006-05-12
IPC分类号： A61F2/02 , A61K31/727 , A61L27/54 , A61L27/34
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/416 , Y10T428/31544 , C08L79/02
摘要： Described are immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized.
摘要翻译： 描述的是固定的生物活性实体，其在机械操作实体所固定的基底材料之后保持显着的生物活性。
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公开(公告)号：US06328765B1
公开(公告)日：2001-12-11
申请号：US09205521
申请日：1998-12-03
IPC分类号： A61F224
CPC分类号： A61F2/2846 , A61F2/2803 , A61F2/30907 , A61F2002/2817 , A61F2002/30235 , A61F2002/30784 , A61F2002/30971 , A61F2230/0069 , A61K38/00 , A61L27/16 , A61L27/18 , A61L27/56 , A61L27/58 , A61L27/54 , A61L27/22 , C08L83/04 , C08L81/06 , C08L77/00 , C08L75/04 , C08L69/00 , C08L67/02 , C08L33/14 , C08L33/12 , C08L27/18 , C08L33/04
摘要： There are numerous medical situations involving deficiencies of living tissue and where increase of living tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living tissue that is desired for treatment of the tissue deficiency. At least one tissue stimulating molecular substance is placed within the established space for the purpose of stimulating the growth of desired living tissue within the established space. A kit for the generation of desired living tissue, comprised of the components mentioned above, is also disclosed.
摘要翻译： 存在许多涉及活组织缺陷的医疗情况，并且需要增加生物体组织质量。 描述了一种方法，其中能够被活细胞和组织穿透的构造的壳状装置被植入到哺乳动物的身体中，以便建立空间，该空间至少部分地由 装置。 该装置的结构使得所建立的空间的构造基本上与用于治疗组织缺陷所需的活组织的构型相同。 将至少一种刺激组织的分子物质放置在所建立的空间内，以刺激所建立的空间内期望的活组织的生长。 还公开了用于产生由上述组分组成的所需活组织的试剂盒。
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公开(公告)号：US09415193B2
公开(公告)日：2016-08-16
申请号：US13603296
申请日：2012-09-04
申请人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
发明人： Carey V. Campbell , Robert L. Cleek , Daniel L. Crandall , James F. Davidson , Paul D. Drumheller , Cody L. Hartman , Theresa A. Holland , Thane L. Kranzler , Mei Li , Gregory LoStracco , Bruce M. Steinhaus , Benjamin M. Trapp , Thomas G. Triebes
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L2300/602 , A61M2025/105 , A61M2025/1081 , F04C2270/0421
摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.
摘要翻译： 本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。 本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。 本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。
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