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48 条记录 (耗时 0.046 秒)

    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of Alzheimer's disease (AD)
    15.
    发明授权
    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of Alzheimer's disease (AD) 失效
    用于还原淀粉状蛋白β肽42（abeta42）产生和用于治疗阿尔茨海默病（AD）的烟酸组合物

    公开(公告)号：US08541435B2

    公开(公告)日：2013-09-24

    申请号：US12737323

    申请日：2009-07-09

    申请人： Uday Saxena ,  Venkateswarulu Akella

    发明人： Uday Saxena ,  Venkateswarulu Akella

    IPC分类号： A61K31/435 ,  C07D213/79

    CPC分类号： A61K31/455 ,  A61K31/05 ,  A61K31/12 ,  A61K31/192 ,  A61K31/196 ,  A61K2300/00

    摘要： The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.

    摘要翻译： 本发明公开了（1）烟酸与α-甲氧基对羟基苯基化合物如丁子香酚，香草醛，阿朴替林，阿魏酸，异钌酸和丁子香酚环氧化物的酚酯混合物和（2）上述杂合体的共晶体，特别是共晶体 烟酸 - 丁子香酚与共晶体如丁子香酚和草酸的混合物（3）包含烟酸和一种或多种小分子/增效剂如丁子香酚，姜黄素，肉桂酸，甲氯芬那酸的组合的新型药物组合物及其在治疗 由淀粉样β肽-42（Abeta42）的过剩产生引起的疾病或疾病，其沉积，积累和斑块形成，包括阿尔茨海默病，痴呆和轻度认知障碍以及其他神经变性疾病如帕金森病和缺血性中风。

    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of alzheimer's disease (ad)
    16.
    发明申请
    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of alzheimer's disease (ad) 失效
    用于还原淀粉状蛋白β肽42（abeta 42）生产和用于治疗阿尔茨海默氏病（ad）的烟酸组合物

    公开(公告)号：US20110097347A1

    公开(公告)日：2011-04-28

    申请号：US12737323

    申请日：2009-07-09

    申请人： Uday Saxena ,  Venkateswarulu Akella

    发明人： Uday Saxena ,  Venkateswarulu Akella

    IPC分类号： A61K31/4406 ,  C07D213/80 ,  C07D405/12 ,  A61K31/4427 ,  A61K31/7088 ,  A61K38/02 ,  A61K39/00 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00

    CPC分类号： A61K31/455 ,  A61K31/05 ,  A61K31/12 ,  A61K31/192 ,  A61K31/196 ,  A61K2300/00

    摘要： The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.

    摘要翻译： 本发明公开了（1）烟酸与α-甲氧基对羟基苯基化合物如丁子香酚，香草醛，阿朴替林，阿魏酸，异钌酸和丁子香酚环氧化物的酚酯混合物和（2）上述杂合体的共晶体，特别是共晶体 烟酸 - 丁子香酚与共晶体如丁子香酚和草酸的混合物（3）包含烟酸和一种或多种小分子/增效剂如丁子香酚，姜黄素，肉桂酸，甲氯芬那酸的组合的新型药物组合物及其在治疗 由淀粉样蛋白β肽42（A＆bgr; 42）的过量产生引起的疾病或疾病，其沉积，积累和斑块形成，包括阿尔茨海默病，痴呆和轻度认知障碍以及其他神经变性疾病如帕金森病和缺血性 行程。

    METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY
    17.
    发明申请
    METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY 审中-公开
    过氧化物酶活性升高的方法和组合物

    公开(公告)号：US20100297673A1

    公开(公告)日：2010-11-25

    申请号：US12441924

    申请日：2007-09-20

    申请人： Ish Khanna ,  Ram Pillarisetti ,  Uday Saxena

    发明人： Ish Khanna ,  Ram Pillarisetti ,  Uday Saxena

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/28 ,  G01N33/92 ,  G01N2500/10 ,  G01N2800/044

    摘要： A novel method of identifying compounds capable of upregulating Peroxiredoxin activity is disclosed. The method includes providing a sample of cells that express Peroxiredoxin, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of Peroxiredoxin activity within the cell sample after the contacting step. Peroxiredoxin inducers identified by the method and uses therefore to upregulate Peroxiredoxin activity in subjects and to reduce LDL and/or VLDL levels and to prevent or treat atherosclerosis and inflammatory disorders such as arthritis in subjects are also described. The invention also provides a method of treatment of inflammatory and cardiovascular diseases which comprises providing a patient in need of treatment with an effective amount of a composition that increases Peroxiredoxin protein or activity.

    摘要翻译： 公开了鉴定能够上调过氧化还原毒素活性的化合物的新方法。 该方法包括提供表达过氧化还原毒素的细胞样品，提供候选化合物的样品，接触细胞样品和化合物样品，以及在接触步骤之后测量细胞样品内过氧化还原毒素活性的定量指标。 本文还描述了通过该方法和用途鉴定的过氧化还原毒素诱导剂，以上调受试者中的过氧化还原毒素活性并降低LDL和/或VLDL水平并预防或治疗动脉粥样硬化和炎症性疾病如受试者中的关节炎。 本发明还提供了一种治疗炎性和心血管疾病的方法，其包括提供需要治疗的患者，所述治疗有效量的增加过氧化还原蛋白或活性的组合物。