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公开(公告)号：US20070054939A1
公开(公告)日：2007-03-08
申请号：US10561989
申请日：2004-06-02
申请人： Philippe Guedat , Francois Collonges , Herve Dumas , Jean-Yves Ortholand , Jacques Decerprit , Jaxques Barbanton , Robert Foster , Peter Kane , Bernd Went
发明人： Philippe Guedat , Francois Collonges , Herve Dumas , Jean-Yves Ortholand , Jacques Decerprit , Jaxques Barbanton , Robert Foster , Peter Kane , Bernd Went
IPC分类号： A61K31/4545 , A61K31/454 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D495/04
摘要： The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2′, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要翻译： 本发明涉及通式（I）的噻唑基哌啶衍生物：其中：A表示选自以下基团a1和a2的基团：G表示选自以下基团g1，g2和g3的键或二价基团： 和R 1，R 2，R 2，R 3，R 4，R 4， >，R 5，Y和Z如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常。
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12.发明授权Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use 失效具有醛糖还原抑制性质的硝基甲基酮化合物及其使用方法公开(公告)号：US06559185B2
公开(公告)日：2003-05-06
申请号：US09438979
申请日：1999-11-12
IPC分类号： A61K3118
CPC分类号： C07D209/48 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07C2601/02 , C07C2601/04 , C07C2602/08 , C07D307/84 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68
摘要： The present invention relates to the compounds of formula: in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
摘要翻译： 本发明涉及下式的化合物：其中R1，R2，R3，E，A，X，Z，p和n如本文所定义。 这些化合物是醛糖还原酶抑制剂。
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13.发明申请N-Benzodioxolyl, n-benzodioxanyl and n-benzodioxepinyl arylcarboxamide derivatives and pharmaceutical compositions comprising them 审中-公开N-苯并二恶唑基，正苯并二氧杂环己烷基和正苯并二氧杂环丙基芳基甲酰胺衍生物和包含它们的药物组合物公开(公告)号：US20060058372A1
公开(公告)日：2006-03-16
申请号：US10532587
申请日：2003-10-01
申请人： Herve Dumas , Jacques Barbanton , Francois Collonges , Jacques Decerprit , Jean-Yves Ortholand , David Benzies , Stuart Cameron , Richard Foster , Stefan Guessregen , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt , Mark Warne
发明人： Herve Dumas , Jacques Barbanton , Francois Collonges , Jacques Decerprit , Jean-Yves Ortholand , David Benzies , Stuart Cameron , Richard Foster , Stefan Guessregen , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt , Mark Warne
IPC分类号： A61K31/335 , C07D321/10
CPC分类号： C07D405/12 , C07C65/24 , C07C65/34 , C07C69/007 , C07C69/616 , C07C271/12 , C07D317/46 , C07D319/18 , C07D319/20 , C07D321/10 , C07F7/1804
摘要： The present invention relates to a compound of the formula (I): in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof in all proportions, which can be used in the treatment of dyslipidaemia, and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式（I）化合物：其中T，A，R，B Xi，Yi和n如权利要求1中所定义，以及其药学上可用的衍生物，溶剂合物和立体异构体，其包含混合物 其可以用于治疗血脂异常的各种比例，以及包含该脂质体的药物组合物
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公开(公告)号：US5932765A
公开(公告)日：1999-08-03
申请号：US955624
申请日：1997-10-22
IPC分类号： C07D333/16 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/48 , A61K31/12 , A61K31/16 , A61K31/167 , A61K31/18 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/45 , A61P3/10 , A61P9/10 , A61P13/12 , A61P27/12 , A61P43/00 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/38 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D209/48 , C07D211/76 , C07D307/79 , C07D307/84 , C07D307/85 , C07D333/20 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07D333/70 , C07C233/00
CPC分类号： C07D209/48 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D307/84 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07C2101/02 , C07C2101/04 , C07C2102/08
摘要： The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
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15.发明申请Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems 有权用于治疗糖尿病相关问题的芳酰基-O-哌啶衍生物公开(公告)号：US20070254919A1
公开(公告)日：2007-11-01
申请号：US11629176
申请日：2005-05-19
申请人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Herve Dumas , Marie Denault , Stephane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
发明人： Philippe Guedat , Francois Collonges , Olivier Chevreuil , Herve Dumas , Marie Denault , Stephane Yvon , Peter Kane , Julia Lainton , Avril Robertson , Bernd Wendt
IPC分类号： A61K31/445 , A61P3/10 , C07D211/06
CPC分类号： C07D211/46 , C07D211/96 , C07D213/12 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12
摘要： The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
摘要翻译： 本发明涉及通式（I）的芳酰基-O-哌啶结构的衍生物：其中R 1，R 2，R 3， SUP>和R 4'如说明书中所定义。 式（I）化合物用于治疗高甘油三酯血症，高胆固醇血症和血脂异常，以及预防或治疗肥胖症的应用。
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16.发明授权Nitromethyl ketones, process for preparing them and compositions containing them 失效硝基乙基酮，其制备方法和含有它们的组合物
公开(公告)号：US6043281A
公开(公告)日：2000-03-28
申请号：US257046
申请日：1999-02-25
IPC分类号： C07D333/16 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/48 , A61K31/12 , A61K31/16 , A61K31/167 , A61K31/18 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/45 , A61P3/10 , A61P9/10 , A61P13/12 , A61P27/12 , A61P43/00 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/38 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D209/48 , C07D211/76 , C07D307/79 , C07D307/84 , C07D307/85 , C07D333/20 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07D333/70 , A61K31/04
CPC分类号： C07D209/48 , C07C205/45 , C07C225/22 , C07C233/33 , C07C233/61 , C07C233/76 , C07C235/24 , C07C235/56 , C07C237/22 , C07C255/56 , C07C311/21 , C07C311/60 , C07C317/24 , C07C323/22 , C07D307/84 , C07D333/22 , C07D333/56 , C07D333/62 , C07D333/68 , C07C2101/02 , C07C2101/04 , C07C2102/08
摘要： The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.
摘要翻译： 本发明涉及下式的化合物：其中R1，R2，R3，E，A，X，Z，p和n如本文所定义。 这些化合物是醛糖还原酶抑制剂。
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