摘要:
The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2′, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
摘要:
Systems and method for authenticating users are presented. A system can send a passkey to a user interface of a known device. A user can then send a messaging service message with the passkey from a second device to the system. After receiving the message from the user, the system can extract the passkey from the message, and compare the received passkey against the passkey originally sent to the user. The known device and the second device can each have separate and unique device identifiers.
摘要:
A water removal device to withdraw virtually all the water from the drain in the bottom of a swimming pool comprising an elongated lower suction or vacuum housing including a plurality of perforations or holes formed therein to receive water from a pool drain and an upper suction or vacuum source to create a suction or vacuum to draw water from the pool drain through the perforations or holes into and through the lower suction or vacuum housing to remove the water from the pool drain.
摘要:
The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations.
摘要:
A system for monitoring the performance of at least one task associated with operation of a retail store. The system includes at least one monitoring device positioned and adapted to provide images of at least one location within the retail store, with each image showing at least one factor related to performance of the at least one task. A controller is adapted to obtain and store images from the at least one monitoring device. An interface is adapted to enable a user to selectively view stored images and to manually analyze the at least one factor shown in the viewed images to evaluate the performance of the at least one task.
摘要:
This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.
摘要:
Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) Chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives.
摘要:
One or more chambers of a multi-chamber vacuum processing apparatus are provided with a high gas flow conductance path to an exhaust volume of the apparatus that is maintained at high vacuum with a high vacuum pump. Separate pumps for the one or more chambers are made unnecessary by providing such chambers with a protective deposition shield or shield set that is configured to substantially protect walls of the chamber and the gas flow conductance path from deposition and to partially impede the gas flow from the chamber through the gas flow conductance path to the exhaust volume so that the chamber can be operated at a higher pressure than that of the exhaust volume and the chambers can be operated at different pressures and without cross-contamination. Preferably, a nested set of chamber shields is used. A controller is programmed to control the processing of wafers in the chambers by controlling the supply of process gas into the chambers.
摘要:
A keg topping device for emplacing an advertising component on top of a keg includes a flat disc surface with an opening therein to fit the device around the mouth of a keg. The opining in the disc forms an inner rim, the perimeter of which, can be fastened to the base around the mouth of the keg by an adhesive. The advertising component is disposed on a surface of the disc member, and in place on the keg, is exposed to view from above. The surface of the disc member, surrounding the opening, is a continuous surface that is free from perforations.
摘要:
A method, apparatus, and computer instructions for improving performance and scalability of common information model object (CIMOM) by using a hardware management console (HMC) repository. The HMC repository includes storage of HMC objects, an HMC object model and a common interface (CIM Wrapper) for accessing to HMC objects. The HMC object model allows the user to store and retrieve the CIM objects and their associations efficiently. A CIM provider may access HMC objects through a common interface (CIM Wrapper), so that different repositories are allowed to be used without significant changes to the underlying server code (CIM provider). A CIM provider may also call the HMC repository directly for more efficient operations because the number of times conversions made between the CIM object and the repository object are greatly decreased.