摘要:
A method of applying precious and semi-precious metals to cigars such that the draw and ignitability of the cigar remains unaffected by the application. An embodiment of the present invention includes a composition and method of applying edible gold leaf to the external surface or wrapper of a cigar or rolled tobacco product.
摘要:
The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
摘要:
The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要:
Illegal, unauthorized, uncompensated and/or under-compensated utilization of computing application functionality may be mitigated at least in part by controlling access to executable instructions that implement the computing application functionality. The executable instructions may be executed by a set of one or more virtual machines provisioned by a multi-tenant virtual resource provider. The virtual resource provider may provision the virtual machines and other virtual resources with a set of implementation resources managed by a control plane of the virtual resource provider. The control plane may perform a number of control functions for the virtual resource provider including management and enforcement of virtual resource access policies such as one or more policies collectively specifying that the computing application functionality is to be accessed in accordance with a license or agreement between a third party provider or vendor of the computing application functionality and a user of the computing application functionality.
摘要:
The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要:
The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA molecules that may trigger or mediate RNAi (siRNA). Compositions of the invention include kits that include an RNase III domain-containing polypeptide. The present invention further concerns methods using polypeptides with RNase III activity for generating RNA molecules that effect RNAi, including the generation of a number of RNA molecules to the same target.
摘要:
A charging system of the present invention is connectable to a power grid having a monitoring device. The monitoring device monitors the power delivered to a plurality of loads and determines a power factor and a power factor correction value associated with the loads. The power factor correction value indicates the difference between the power factor and unity. The charging system includes an electrical device, a charger in communication with the electrical device, a charging controller, a power factor correction circuit, a communication device, and a controller. The communication device of the charger receives a data signal from the monitoring device indicative of the power factor correction value associated with the plurality of loads. The power factor correction circuit is configured to communicate an input current to and from the power grid, which adjusts the power factor of the associated loads to about unity.
摘要:
Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.
摘要:
A receiver utilizes an array of complex accumulation registers to form an image of the average chip shape or, as appropriate, chip edge shape, of the received signal over a specified period of time as a time series of complex power measurements. The receiver divides the length of the chip into a plurality of ranges, or bins, and, as appropriate, extends the bins to cover additional chips or portions thereof. When a sample is taken, the receiver enables the respective registers that are associated with the corresponding bin or bins, and the respective registers then accumulates the associated power measurement. The receiver uses the accumulated measurements from selected registers and/or selected groups of registers, to produce the correlation values that are needed to perform one or more correlation techniques and/or one or more multipath mitigation techniques. As appropriate, the sizes and/or starting points of the bins, and/or the selections of the bins for the various groupings may be altered, to change the spacings, locations, and so forth to which correlation values correspond.
摘要:
The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.