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公开(公告)号：US20060246061A1
公开(公告)日：2006-11-02
申请号：US11477036
申请日：2006-06-28
申请人： M. MBow , Patrick Branigan , Jill Giles-Komar , Linda Snyder , George Heavner
发明人： M. MBow , Patrick Branigan , Jill Giles-Komar , Linda Snyder , George Heavner
IPC分类号： A61K39/395 , C12P21/04
CPC分类号： C07K16/24 , A61K31/00 , A61K39/3955 , A61K45/06 , A61K2039/53 , A61K2039/57 , C07K16/00 , A61K2300/00
摘要： Methods for generating monoclonal antibodies in Th1-biased rodents are disclosed. The monoclonal antibodies are useful as therapeutic agents, diagnostic agents or research reagents.
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12.发明授权公开(公告)号：US08329170B2
公开(公告)日：2012-12-11
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号：US20120282170A1
公开(公告)日：2012-11-08
申请号：US13547557
申请日：2012-07-12
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/42 , C12N5/071 , G01N33/566 , A61K51/00 , C12N1/00 , G01N33/577 , A61P29/00 , A61P21/02 , A61P23/00 , A61P25/20 , A61P31/00 , A61P17/06 , A61P37/04 , A61P37/06 , A61P25/24 , A61P25/18 , A61P11/06 , C12N15/13
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译： 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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14.发明申请公开(公告)号：US20120207670A1
公开(公告)日：2012-08-16
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , A61P29/00 , A61P23/00 , A61P37/00 , A61P37/04 , A61P5/00 , A61P37/06 , A61P23/02 , A61K51/00 , A61P21/00 , A61P21/02 , A61P25/20 , A61P17/06 , A61P31/00
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号：US07820169B2
公开(公告)日：2010-10-26
申请号：US12268955
申请日：2008-11-11
IPC分类号： A61K39/395 , A61K31/573 , A61K49/00 , C07K16/00
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.
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公开(公告)号：US20090202549A1
公开(公告)日：2009-08-13
申请号：US11722312
申请日：2005-12-20
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12N5/10 , C12N5/02 , C12N15/63 , C07K16/24 , C07H21/04
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20090074794A1
公开(公告)日：2009-03-19
申请号：US12270191
申请日：2008-11-13
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.
摘要翻译： 本发明涉及通过施用包含SEQ ID NO：7的重链可变区和SEQ ID NO：8的轻链可变区的抗TNF抗体来抑制具有类风湿性关节炎，银屑病关节炎或强直性脊柱炎的患者中的TNF， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段。
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18.发明申请Methods and compositions for treating renal cell carcinoma related pathologies 审中-公开用于治疗肾细胞癌相关病理的方法和组合物公开(公告)号：US20060246070A1
公开(公告)日：2006-11-02
申请号：US11241269
申请日：2005-09-30
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/565
摘要： The present invention relates to methods for treating at least one renal cell carcinoma related condition or pathology, including therapeutic compositions, methods and devices, using TNF antagonists.
摘要翻译： 本发明涉及使用TNF拮抗剂治疗至少一种肾细胞癌相关病症或病理学的方法，包括治疗组合物，方法和装置。
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公开(公告)号：US08241899B2
公开(公告)日：2012-08-14
申请号：US12271120
申请日：2008-11-14
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译： 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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公开(公告)号：US08080247B2
公开(公告)日：2011-12-20
申请号：US11722312
申请日：2005-12-20
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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