公开(公告)号：US20080097400A1

公开(公告)日：2008-04-24

申请号：US11925540

申请日：2007-10-26

申请人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Theodore Lamson ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Theodore Lamson ,  Amrish Walke

IPC分类号： A61M25/00

CPC分类号： A61F11/002 ,  A61B5/065 ,  A61B10/06 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1604 ,  A61B17/1608 ,  A61B17/1679 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/32075 ,  A61B17/3478 ,  A61B34/20 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61B90/16 ,  A61B90/361 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/320004 ,  A61B2017/3486 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2034/2051 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1052

摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.

公开(公告)号：US20050245906A1

公开(公告)日：2005-11-03

申请号：US10912578

申请日：2004-08-04

申请人： Joshua Makower ,  John Chang ,  Julia Vrany ,  Amrish Walke

发明人： Joshua Makower ,  John Chang ,  Julia Vrany ,  Amrish Walke

IPC分类号： A61B5/06 ,  A61B17/22 ,  A61B17/24 ,  A61B17/34 ,  A61B19/00 ,  A61F2/00 ,  A61F2/18 ,  A61F2/82 ,  A61F13/00 ,  A61K9/22 ,  A61M1/00 ,  A61M25/00 ,  A61M29/00

CPC分类号： A61M31/002 ,  A61B5/06 ,  A61B5/064 ,  A61B5/411 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/22061 ,  A61F2/18 ,  A61F2/82 ,  A61F2002/825 ,  A61F2250/0039 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/105 ,  A61M2025/1052

摘要： Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.

摘要翻译： 用于将药物和其他物质递送到人或动物身体内的位置以进行治疗或诊断鼻窦炎和各种其他疾病的可植入装置和方法。 本发明包括可植入物质输送装置，其包括控制物质从储存器中流出的速率的储存器和屏障。 输送装置可以使用导线，导管，端口，引导器和其它存取装置进入体内。 在一些实施方案中，递送装置可以在引入体内之前装载一种或多种所需物质。 在其他实施方案中，递送装置在输送装置已经被引入体内之后被装载和/或重新加载所需物质。

公开(公告)号：US20080097514A1

公开(公告)日：2008-04-24

申请号：US11925357

申请日：2007-10-26

申请人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Theodore Lamson ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Theodore Lamson ,  Amrish Walke

IPC分类号： A61M29/02 ,  A61F13/00

CPC分类号： A61F11/002 ,  A61B5/065 ,  A61B10/06 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1604 ,  A61B17/1608 ,  A61B17/1679 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/32075 ,  A61B17/3478 ,  A61B34/20 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61B90/16 ,  A61B90/361 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/320004 ,  A61B2017/3486 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2034/2051 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1052

摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.

公开(公告)号：US20080097516A1

公开(公告)日：2008-04-24

申请号：US11926524

申请日：2007-10-29

申请人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Theodore Lamson ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Theodore Lamson ,  Amrish Walke

IPC分类号： A61M29/02

CPC分类号： A61F11/002 ,  A61B5/065 ,  A61B10/06 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1604 ,  A61B17/1608 ,  A61B17/1679 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/32075 ,  A61B17/3478 ,  A61B34/20 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61B90/16 ,  A61B90/361 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/320004 ,  A61B2017/3486 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2034/2051 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1052

摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.

公开(公告)号：US20060004323A1

公开(公告)日：2006-01-05

申请号：US10944270

申请日：2004-09-17

申请人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vrany ,  Amrish Walke

IPC分类号： A61M1/00 ,  A61M29/00

CPC分类号： A61M29/02 ,  A61B5/6852 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/3403 ,  A61B17/3421 ,  A61B18/1492 ,  A61B2017/22039 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2034/2051 ,  A61F2/186 ,  A61F2/82 ,  A61F2/90 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0026 ,  A61M25/005 ,  A61M25/0082 ,  A61M25/0102 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0177 ,  A61M2025/1072 ,  A61M2025/1079 ,  A61M2025/109 ,  A61M2029/025 ,  A61M2210/0681 ,  A61M2210/1028

摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat.

公开(公告)号：US20070129751A1

公开(公告)日：2007-06-07

申请号：US11355512

申请日：2006-02-16

申请人： Ketan Muni ,  Carlos Fernandez ,  Joshua Makower ,  John Chang ,  William Facteau

发明人： Ketan Muni ,  Carlos Fernandez ,  Joshua Makower ,  John Chang ,  William Facteau

IPC分类号： A61M29/00

CPC分类号： A61B17/24 ,  A61B18/12 ,  A61B2017/22061 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61M25/0041 ,  A61M25/0108 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1002 ,  A61M29/02 ,  A61M31/005 ,  A61M2025/1086 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/0681 ,  A61M2230/005

摘要： Devices, systems and methods wherein a dilator, such as a balloon or other expandable member, is positionable within the frontal sinus ostium and adjacent frontal recess and useable to dilate the frontal sinus ostium and substantially all of the frontal sinus recess without requiring repositioning and repeated re-expansion of the dilator. One balloon catheter device of the invention comprises a catheter body that is less than about 50 cm in length (and in some embodiments less than 25 cm in length and a semi-compliant or non-compliant balloon on the catheter body. The balloon may have a working length of about 12 mm to about 30 mm and a width at its widest point when fully inflated of about 2 mm to about 7 mm. Such balloon may be constructed to withstand inflation pressures of about 12 atmospheres. In some embodiments, the dilator is advanced through or over a guide (e.g., guidewire or guide catheter) that has a preformed shape.

摘要翻译： 装置，系统和方法，其中扩张器，例如气囊或其他可扩张构件，可定位在额窦口和相邻的前额槽内，并且可用于扩张额窦口和基本上所有的额叶窦腔，而不需要重新定位并重复 扩张器重新扩张。 本发明的一个气囊导管装置包括导管主体，其长度小于约50cm（并且在一些实施例中小于25cm长，导管主体上具有半顺应性或非顺应性气囊），球囊可具有 约12毫米至约30毫米的工作长度，当完全膨胀约2毫米至约7毫米时，其最宽点处的宽度可以构造成可承受大约12个大气压的充气压力在一些实施例中，扩张器 通过或超过具有预成形形状的引导件（例如，导丝或引导导管）。

公开(公告)号：US08425488B2

公开(公告)日：2013-04-23

申请号：US11749733

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61M31/00 ,  A61M1/00 ,  A61M3/02 ,  A61M3/00 ,  A61N1/30

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US20120310145A1

公开(公告)日：2012-12-06

申请号：US13587806

申请日：2012-08-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61N1/30

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first car by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于通过将支撑系统安装到患者的头部来治疗具有第一耳朵和第二耳朵功能的头部的患者的系统和方法，使得所述支撑系统与所述第一耳朵的目标组织对准; 通过激励由所述支撑系统支撑的离子电渗电极向所述第一轿厢施加治疗剂; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US20080262468A1

公开(公告)日：2008-10-23

申请号：US11749733

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61M31/00

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US20080097515A1

公开(公告)日：2008-04-24

申请号：US11926326

申请日：2007-10-29

申请人： John Chang ,  Joshua Makower ,  Julia Vranny ,  Theodore Lamson ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vranny ,  Theodore Lamson ,  Amrish Walke

IPC分类号： A61M29/02

CPC分类号： A61F11/002 ,  A61B5/065 ,  A61B10/06 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1604 ,  A61B17/1608 ,  A61B17/1679 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/32075 ,  A61B17/3478 ,  A61B34/20 ,  A61B50/13 ,  A61B50/15 ,  A61B50/20 ,  A61B90/16 ,  A61B90/361 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/320004 ,  A61B2017/3486 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2034/2051 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1052

摘要： Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.