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公开(公告)号：US08067215B2
公开(公告)日：2011-11-29
申请号：US10580447
申请日：2004-11-22
申请人： Stuart Greenhalgh , Kenneth Charles Symes , Yvonne Armitage , Jonathan Hughes , Gary Richardson
发明人： Stuart Greenhalgh , Kenneth Charles Symes , Yvonne Armitage , Jonathan Hughes , Gary Richardson
摘要： A process for preparing a polymer of an ethylenically unsaturated monomer, in which the monomer is obtainable from a biocatalysed reaction or a fermentation process, and wherein the monomer contains cellular material and/or components of a fermentation broth, forming the polymer by polymerizing the ethylenically unsaturated monomer or a monomer mixture comprising the ethylenically unsaturated monomer, wherein there is substantially no removal of the cellular material and/or components of the fermentation broth from the ethylenically unsaturated monomer.
摘要翻译： 一种制备烯键式不饱和单体的聚合物的方法，其中单体可从生物催化反应或发酵方法获得，并且其中所述单体含有发酵液的细胞材料和/或组分，通过聚合烯属不饱和单体形成聚合物 不饱和单体或包含烯键式不饱和单体的单体混合物，其中基本上不从烯属不饱和单体中除去发酵液的细胞材料和/或组分。
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公开(公告)号：US08067193B2
公开(公告)日：2011-11-29
申请号：US10587583
申请日：2005-01-20
IPC分类号： C12P1/00
CPC分类号： C02F1/56 , C02F1/001 , C02F1/281 , C02F2103/32 , C02F2103/34 , C02F2209/09 , Y02E50/17
摘要： A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation process for the production of a fermentation product, in which the liquor has been subjected to a temperature of at least 50° C., wherein the solids-liquid separation stage is assisted by a treatment system, characterised in that the treatment system comprises an anionic polymer selected from natural polymers and modified natural polymers having a high anionic charge such that the equivalent weight is below 300, and synthetic polymers formed from at least 50% by weight anionic monomer units.
摘要翻译： 一种通过使液体经受固体 - 液体分离阶段从发酵液中分离悬浮固体的方法，其中发酵液体是在用于生产发酵产物的发酵方法中生产的，其中液体经受了温度 至少50℃，其中固体 - 液体分离阶段由处理系统辅助，其特征在于所述处理系统包含选自天然聚合物和具有高阴离子电荷的改性天然聚合物的阴离子聚合物，使得当量 低于300，合成聚合物由至少50重量％的阴离子单体单元形成。
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13.发明授权Biocatalytic manufacturing of (meth) acrylylcholine or 2-(N, N-dimethylamino) ethyl (meth) acrylate 失效（甲基）丙烯酰胆碱或（甲基）丙烯酸2-（N，N-二甲基氨基）乙酯的生物催化制备公开(公告)号：US07754455B2
公开(公告)日：2010-07-13
申请号：US10591775
申请日：2005-03-09
IPC分类号： C12P7/62
CPC分类号： C12P13/00 , C12P7/62 , C12P13/001
摘要： A biocatalytic method for the synthesis of 2-(N,N-dimethyl amino)ethanol and/or choline esters of acrylic acid and/or methacrylic acid comprising reacting 2-(N,N-dimethylamino)ethanol and/or choline with acrylyl-CoA and/or methacrylyl-coA in the presence of a biocatalyst with choline acetyltransferase activity. The acrylyl-CoA and/or the methacrylyl CoA is formed by the reaction of acrylate and/or methacrylate with coenzyme A in the presence of ATP and a biocatalyst with S-acetyl coenzyme A synthetase activity.
摘要翻译： 一种用于合成丙烯酸和/或甲基丙烯酸的2-（N，N-二甲基氨基）乙醇和/或胆碱酯的生物催化方法，包括使2-（N，N-二甲基氨基）乙醇和/或胆碱与丙烯酰基 - CoA和/或甲基丙烯酰辅酶A在具有胆碱乙酰转移酶活性的生物催化剂存在下进行。 通过丙烯酸酯和/或甲基丙烯酸酯与辅酶A在ATP和具有S-乙酰辅酶A合成酶活性的生物催化剂的存在下的反应形成丙烯酰辅酶A和/或甲基丙烯酰CoA。
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14.发明授权公开(公告)号：US07582444B2
公开(公告)日：2009-09-01
申请号：US10523229
申请日：2003-07-28
申请人： Jonathan Hughes
发明人： Jonathan Hughes
摘要： Process for improving the separation efficiency of residual solid matter from the liquid phase of an aqueous acid hydrolysate of a naturally occurring polysaccharide comprising dissolved sugars, and residual acid wherein a flocculating agent(s) is added to the aqueous mixture in an effective amount, and a process of producing fermentation products comprising the steps of, (i) hydrolysing a particulate polysaccharide based plant derived material in an acid medium, and thereby forming an aqueous mixture comprising dissolved sugar and solid matter, (ii) subjecting the aqueous mixture to one or more separation stages in which solid matter are removed from the aqueous phase, (iii) adjusting the pH of the obtained aqueous phase to a pH of at least 4, (iv) fermenting the dissolved sugars of the aqueous phase by a microorganism to produce a fermentation product, (v) isolating the fermentation product, wherein in at least one separation stage in step (ii) a flocculating agent is added to the aqueous mixture in an effective amount.
摘要翻译： 用于提高含有溶解糖的天然存在的多糖的酸性水解产物的水相中的残留固体物质的分离效率的方法和其中以有效量向所述含水混合物中加入絮凝剂的残余酸，以及 一种生产发酵产物的方法，包括以下步骤：（i）在酸性介质中水解基于多糖的植物衍生物质，从而形成含有溶解的糖和固体物质的水性混合物，（ii）将含水混合物经1或 更多的分离阶段，其中从水相中除去固体物质，（iii）将所得水相的pH调节至至少4的pH，（iv）通过微生物发酵水相的溶解糖以产生 发酵产物，（v）分离发酵产物，其中在步骤（ii）的至少一个分离阶段中，将絮凝剂加入到水溶液 有效的混合物。
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公开(公告)号：US20070170125A1
公开(公告)日：2007-07-26
申请号：US10587582
申请日：2005-01-20
申请人： Jonathan Hughes , Rajesh Mistry , Kenneth Symes
发明人： Jonathan Hughes , Rajesh Mistry , Kenneth Symes
IPC分类号： C02F1/00
CPC分类号： C02F1/56 , C02F2103/28
摘要： A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation process for the production of a fermentation product, and which liquor comprises lignin, wherein the solids-liquid separation stage is assisted by a treatment system, characterised in that the treatment system comprises an anionic polymer, with the proviso that the treatment system and does not include a cationic polymer having an intrinsic viscosity (IV) of at least 4 dl/g.
摘要翻译： 一种通过使液体经受固体 - 液体分离阶段将发酵液体分离出的悬浮固体的方法，其中发酵液体在用于生产发酵产物的发酵方法中产生，并且哪种液体包含木质素，其中固体 - 液体分离阶段由处理系统辅助，其特征在于处理系统包含阴离子聚合物，条件是处理系统并且不包括特性粘度（IV）至少为4dl / g的阳离子聚合物。
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公开(公告)号：US20050286117A1
公开(公告)日：2005-12-29
申请号：US10531080
申请日：2003-10-06
申请人： Jonathan Hughes , Stuart Coomber , Carl Brown , Alexander Topping
发明人： Jonathan Hughes , Stuart Coomber , Carl Brown , Alexander Topping
摘要： A method of controlling the switching of an optically addressable spatial light modulator (OASLM), to a first surface of which a write light signal is applied and to a second surface of which a read light signal is applied. The method comprises applying a bipolar switching waveform to control electrodes of the (OASLM) during each write cycle such that the leading pulse of the waveform applies a voltage across the (OASLM) which is in the photosensitive direction and the trailing pulse applies a voltage which is not in the photosensitive direction.
摘要翻译： 一种控制光可寻址空间光调制器（OASLM）切换到施加写入光信号的第一表面和施加读取光信号的第二表面的方法。 该方法包括在每个写入周期期间将双极性切换波形施加到（OASLM）的控制电极，使得波形的引导脉冲施加在感光方向上的（OASLM）两端的电压，并且拖尾脉冲施加电压， 不在感光方向。
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公开(公告)号：US20050271770A1
公开(公告)日：2005-12-08
申请号：US10523229
申请日：2003-07-28
申请人： Jonathan Hughes
发明人： Jonathan Hughes
摘要： Process for improving the separation efficiency of residual solid matter from the liquid phase of an aqueous acid hydrolysate of a naturally occurring polysaccharide comprising dissolved sugars, and residual acid wherein a flocculating agent(s) is added to the aqueous mixture in an effective amount, and a process of producing fermentation products comprising the steps of, (i) hydrolysing a particulate polysaccharide based plant derived material in an acid medium, and thereby forming an aqueous mixture comprising dissolved sugar and solid matter, (ii) subjecting the aqueous mixture to one or more separation stages in which solid matter are removed from the aqueous phase, (iii) adjusting the pH of the obtained aqueous phase to a pH of at least 4, (iv) fermenting the dissolved sugars of the aqueous phase by a microorganism to produce a fermentation product, (v) isolating the fermentation product, wherein in at least one separation stage in step (ii) a flocculating agent is added to the aqueous mixture in an effective amount.
摘要翻译： 用于提高含有溶解糖的天然存在的多糖的酸性水解产物的水相中的残留固体物质的分离效率的方法和其中以有效量向所述含水混合物中加入絮凝剂的残余酸，以及 一种生产发酵产物的方法，包括以下步骤：（i）在酸性介质中水解基于多糖的植物衍生物质，从而形成含有溶解的糖和固体物质的水性混合物，（ii）将含水混合物经1或 更多的分离阶段，其中固体物质从水相中除去，（iii）将所得水相的pH调节至至少4的pH，（iv）通过微生物发酵水相的溶解糖以产生 发酵产物，（v）分离发酵产物，其中在步骤（ii）的至少一个分离阶段中，将絮凝剂加入到水溶液 有效的混合物。
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公开(公告)号：US06613325B1
公开(公告)日：2003-09-02
申请号：US09585030
申请日：2000-06-01
申请人： Michael J. Amery , Paul Sibbons , Stuart Burnett , Sally-Anne Rickets , Peter A. D. Edwardson , Jonathan Hughes , Derek A. Hollingsbee , Stewart A. Cederholm-Williams , Horace R. Trumbull , Herman Eugene Griffin
发明人： Michael J. Amery , Paul Sibbons , Stuart Burnett , Sally-Anne Rickets , Peter A. D. Edwardson , Jonathan Hughes , Derek A. Hollingsbee , Stewart A. Cederholm-Williams , Horace R. Trumbull , Herman Eugene Griffin
IPC分类号： A61K3848
CPC分类号： A61L31/046 , A61K38/363 , A61K38/482 , A61K38/4833 , A61L24/106 , A61K38/00 , A61K35/14 , A61K2300/00
摘要： In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion formation. Preferred embodiments involve application of a fibrin monomer under polymerizing conditions to the surgical wound site. Unexpectedly, in addition to this improved prevention of adhesions, the more chemically-natural clots, especially the fibrin-monomer based fibrin polymer, also functions as a fibrin sealant, i.e., has adherence, provides hemostasis and promotes wound healing while also functioning as a barrier. In preferred embodiments the novel methods of this invention conveniently use one or more plasma proteins derived from the patient's own blood as to be autologous. Further, the sealant material is preferably substantially free of any added or exogenous enzymes, e.g., thrombin, etc., which catalyze the cleavage of fibrinopeptides A and/or B from fibrinogen. Preferably a fibrin monomer solution is sprayed over the wounded surgical site.
摘要翻译： 根据本发明，已经发现通过将最接近类似于天然凝结材料的材料施加到外科粘连层形成的纤维蛋白聚合物膜。 优选的实施方案涉及在聚合条件下将纤维蛋白单体应用于外科伤口部位。 出人意料的是，除了这种改进的预防粘连之外，化学天然的凝块，特别是基于纤维蛋白单体的纤维蛋白聚合物，也起到纤维蛋白密封剂的作用，即具有粘附性，提供止血和促进伤口愈合，同时也作为 屏障。 在优选的实施方案中，本发明的新方法方便地使用衍生自患者自身血液的一种或多种血浆蛋白为自体的。 此外，密封剂材料优选基本上不含任何加入或外源的酶，例如凝血酶等，其催化纤维蛋白肽A和/或B从纤维蛋白原的切割。 优选地，将纤维蛋白单体溶液喷洒在受伤的外科手术部位上。
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公开(公告)号：USD434027S
公开(公告)日：2000-11-21
申请号：US111854
申请日：1999-10-04
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公开(公告)号：US20090269822A1
公开(公告)日：2009-10-29
申请号：US12499362
申请日：2009-07-08
摘要： A microorganism which is Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. A method of culturing the microorganism in a culture medium comprising urea or urea derivative is claimed. A nitrile hydratase obtainable from the microorganism is claimed. Also claimed is a process of preparing an amide from the corresponding nitrile wherein the nitrile is subjected to a hydration reaction in an aqueous medium in the presence of a biocatalyst selected from the group consisting of a microorganism which is a Rhodococcus rhodochrous strain NCIMB 41164, a mutant thereof and a nitrile hydratase obtainable from Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. Also claimed is a method of storing the Rhodococcus rhodochrous NCIMB 41164.
摘要翻译： 作为玫瑰色红球菌菌株NCIMB 41164或其突变体的微生物。 要求保护在包含尿素或尿素衍生物的培养基中培养微生物的方法。 要求从微生物获得的腈水合酶。 还要求的是从相应的腈制备酰胺的方法，其中腈在水性介质中在生物催化剂存在下进行水合反应，所述生物催化剂选自由玫瑰色红玫瑰色菌株NCIMB 41164， 其突变体和可从Rhodococcus rhodochrous strain NCIMB 41164获得的腈水合酶或其突变体。 还要求保存红玫瑰色红球菌NCIMB 41164的方法。
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