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公开(公告)号：US08114918B2
公开(公告)日：2012-02-14
申请号：US12542260
申请日：2009-08-17
申请人： Joseph B. Schlenoff
发明人： Joseph B. Schlenoff
CPC分类号： C08J5/20 , Y10T428/25 , Y10T428/31855
摘要： A method is described for producing an osmotically compacted polyelectrolyte complex having a first region and a second region, the first region having a greater modulus than the second region. The method comprises contacting an article comprising polyelectrolyte complex to a solution comprising a preferred osmolyte of concentration sufficient to compact said polyelectrolyte complex and terminating the compaction process before the entire article is osmotically compacted.A method is also described for producing a article comprising water and an intermolecular blend of at least one positively charged polyelectrolyte polymer and at least one negatively charged polymer, said article having a core region and a surface region, the surface region having at least twice the elastic modulus of the core region, the method comprising contacting a starting article comprising a blend of said polymers with a solution of osmolyte, wherein the osmolyte is excluded from said article.
摘要翻译： 描述了一种制备具有第一区域和第二区域的渗透压缩的聚电解质络合物的方法，第一区域具有比第二区域更大的模量。 该方法包括将包含聚电解质络合物的制品与含有足以压制所述聚电解质复合物的浓度的优选渗透剂的溶液接触，并在整个制品渗透压实之前终止压实过程。 还描述了一种用于生产包含至少一种带正电荷的聚电解质聚合物和至少一种带负电荷的聚合物的水和分子间共混物的制品的方法，所述制品具有芯区域和表面区域，所述表面区域具有至少两倍于 芯区域的弹性模量，该方法包括将包含所述聚合物的共混物的起始制品与渗透剂溶液接触，其中渗透剂被排除在所述制品之外。
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公开(公告)号：US07722752B2
公开(公告)日：2010-05-25
申请号：US11070770
申请日：2005-03-02
申请人： Joseph B. Schlenoff , Zhijie Sui
发明人： Joseph B. Schlenoff , Zhijie Sui
IPC分类号： G01N27/447 , G01N27/453 , B01D57/02
CPC分类号： G01N27/44752
摘要： A microfluidic device for carrying a liquid, the device comprising a microfluidic channel having an interior wall and a polyelectrolyte film on the interior wall whereby liquid carried by the channel contacts the polyelectrolyte film, the polyelectrolyte film having a thickness of about 1 to about 1000 nanometers and comprising an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer, the predominantly positively charged polymer, the predominantly negatively charged polymer or both containing (i) a pH insensitive positively or negatively charged repeat unit having a pKa greater than 9 or less than 3, and (ii) a pH sensitive repeat unit, the pH sensitive repeat unit having a pKa of 3 to 9, whereby the pH of liquid in the microfluidic channel may be used to control the velocity or direction of electroosmotic flow of the liquid within said microfluidic channel.
摘要翻译： 一种用于携带液体的微流体装置，该装置包括在内壁上具有内壁和聚电解质膜的微流体通道，由该通道承载的液体接触该聚电解质膜，该聚电解质膜具有约1至约1000纳米的厚度 并且包含主要带正电荷的聚合物和主要带负电荷的聚合物的互穿网络，主要为带正电荷的聚合物，主要为带负电荷的聚合物或二者均包含（i）具有pKa大于9的pH不敏感的带正电荷或带负电荷的重复单元 或小于3，和（ii）pH敏感重复单元，pH敏感重复单元的pKa为3至9，由此微流体通道中液体的pH可用于控制电渗流速度或方向 所述微流体通道内的液体。
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公开(公告)号：US20090202816A1
公开(公告)日：2009-08-13
申请号：US12303679
申请日：2007-06-05
申请人： Joseph B. Schlenoff
发明人： Joseph B. Schlenoff
CPC分类号： C01B33/149 , B82Y30/00 , C01P2002/52 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C01P2006/60 , C01P2006/80 , C09C1/3045 , C09C1/3081 , C09K3/1409 , Y10T428/259 , Y10T428/2993
摘要： A nanoparticle has at least one dimension less than 500 nm and comprises a silica surface and a plurality of zwitterionic functional groups covalently bound to the silica surface. Such nanoparticles and dispersions contain such nanoparticle are prepared and used for a variety of purposes.
摘要翻译： 纳米颗粒具有小于500nm的至少一个维度，并且包含二氧化硅表面和共价结合到二氧化硅表面的多个两性离子官能团。 这种纳米颗粒和分散体含有这样的纳米颗粒被制备并用于各种目的。
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14.发明授权Polyelectrolyte complex films for analytical and membrane separation of chiral compounds 有权用于手性化合物分析和膜分离的聚电解质复合膜公开(公告)号：US07365142B2
公开(公告)日：2008-04-29
申请号：US11500085
申请日：2006-08-07
申请人： Joseph B. Schlenoff , Hassan Rmaile
发明人： Joseph B. Schlenoff , Hassan Rmaile
IPC分类号： C08F20/06
CPC分类号： C07B57/00 , C08L25/18 , Y10T428/31743 , Y10T428/31855 , Y10T428/31909
摘要： The present invention is directed to enantioselective polyelectrolyte complex films. Further, said films may be free or isolated membranes, or coatings on substrates such a porous substrates, capillary tubes, chromatographic packing material, and monolithic stationary phases and used to separate chiral compounds. The present invention is also directed to a method for forming such enantioselective polyelectrolyte complex films.
摘要翻译： 本发明涉及对映选择性聚电解质复合膜。 此外，所述膜可以是诸如多孔基材，毛细管，色谱填充材料和整体固定相的基材上的游离或隔离的膜或涂层，并用于分离手性化合物。 本发明还涉及形成这种对映选择性聚电解质复合膜的方法。
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公开(公告)号：US5466930A
公开(公告)日：1995-11-14
申请号：US200213
申请日：1994-02-23
申请人： Joseph B. Schlenoff
发明人： Joseph B. Schlenoff
摘要： A scintillator for absorbing and concentrating radioactive ions within a solution, the scintillator including a solid scintillator and an ionic layer on a surface of and in contact with the solid scintillator. When radioactive ions are absorbed by the ionic layer, the scintillator acts as a light source.
摘要翻译： 用于吸收和浓缩溶液中的放射性离子的闪烁体，所述闪烁体包括固体闪烁体和在固体闪烁体的表面上并与其形成接触的离子层。 当放射性离子被离子层吸收时，闪烁体充当光源。
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公开(公告)号：US09056125B2
公开(公告)日：2015-06-16
申请号：US11130972
申请日：2005-05-17
IPC分类号： A61K31/00 , A61K31/785
CPC分类号： C12N5/0068 , A61K31/16 , A61K31/785 , A61L27/26 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/424 , A61L2400/18 , A61L2420/06 , A61L2430/00 , A61L2430/12 , A61L2430/16 , C12N2537/00
摘要： An article for controlling the attachment and growth of cells on a surface of the article, and a method for the use of the article is provided. The article comprises a substratum having a surface and a film on the surface, the film comprising a network of a net positively charged composition and a net negatively charged composition, wherein the net positively charged composition comprises a net positively charged polyelectrolyte or the net negatively charged composition comprises a net negatively charged polyelectrolyte, and the net positively charged polyelectrolyte or the net negatively charged polyelectrolyte contain (i) a polymer repeat unit having at least two fluorine atoms, or (ii) a polymer repeat unit having a zwitterion group. The method comprises contacting the article with living tissue, living organisms, or with water in an aqueous system comprising living organisms.
摘要翻译： 提供了用于控制制品表面上的细胞的附着和生长的制品以及该制品的使用方法。 该制品包括在表面上具有表面和膜的底物，该膜包含网带正电的组合物和净带负电的组合物的网络，其中净正电荷的组合物包含净带正电的聚电解质或带负电的净 净负极聚电解质，净正电聚合电解质或净负电聚合电解质含有（i）具有至少两个氟原子的聚合物重复单元，或（ii）具有两性离子基团的聚合物重复单元。 该方法包括将物品与活组织，活生物体或与包含活生物体的水系统中的水接触。
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公开(公告)号：US08481017B2
公开(公告)日：2013-07-09
申请号：US11063952
申请日：2005-02-23
IPC分类号： A61K31/74
CPC分类号： C02F1/4693 , G02B1/04 , C08L39/00
摘要： A medium for isolating or releasing an electrostatically charged component from or into an aqueous composition. The medium has a polyelectrolyte film on at least one surface of an article wherein the polyelectrolyte film is characterized by an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer. The predominantly positively charged polymer, the predominantly negatively charged polymer or both contain (i) a pH sensitive imidazole repeat unit having a pKa between 3 and 9, or (ii) a redox sensitive repeat unit selected from the group consisting of quaternized bipyridine repeat units, coordinated metal repeat units, pyrrole repeat units, aniline repeat units, thiophene repeat units and combinations thereof having a redox potential between +1.2 volts and −1.2 volts versus a standard hydrogen electrode.
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公开(公告)号：US20100041777A1
公开(公告)日：2010-02-18
申请号：US12542260
申请日：2009-08-17
申请人： Joseph B. Schlenoff
发明人： Joseph B. Schlenoff
IPC分类号： C08J5/20
CPC分类号： C08J5/20 , Y10T428/25 , Y10T428/31855
摘要： A method is described for producing an osmotically compacted polyelectrolyte complex having a first region and a second region, the first region having a greater modulus than the second region. The method comprises contacting an article comprising polyelectrolyte complex to a solution comprising a preferred osmolyte of concentration sufficient to compact said polyelectrolyte complex and terminating the compaction process before the entire article is osmotically compacted.A method is also described for producing a article comprising water and an intermolecular blend of at least one positively charged polyelectrolyte polymer and at least one negatively charged polymer, said article having a core region and a surface region, the surface region having at least twice the elastic modulus of the core region, the method comprising contacting a starting article comprising a blend of said polymers with a solution of osmolyte, wherein the osmolyte is excluded from said article.
摘要翻译： 描述了一种制备具有第一区域和第二区域的渗透压缩的聚电解质络合物的方法，第一区域具有比第二区域更大的模量。 该方法包括将包含聚电解质络合物的制品与含有足以压制所述聚电解质复合物的浓度的优选渗透剂的溶液接触，并在整个制品渗透压实之前终止压实过程。 还描述了一种用于生产包含至少一种带正电荷的聚电解质聚合物和至少一种带负电荷的聚合物的水和分子间共混物的制品的方法，所述制品具有芯区域和表面区域，所述表面区域具有至少两倍于 芯区域的弹性模量，该方法包括将包含所述聚合物的共混物的起始制品与渗透剂溶液接触，其中渗透剂被排除在所述制品之外。
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公开(公告)号：US20100009148A1
公开(公告)日：2010-01-14
申请号：US12439647
申请日：2007-08-29
申请人： Joseph B. Schlenoff
发明人： Joseph B. Schlenoff
CPC分类号： C08J3/005 , A61L27/14 , A61L27/26 , A61L27/50 , B29K2096/005 , C08J7/042 , C08K3/24 , Y10S977/742 , Y10S977/773 , Y10T428/24843 , Y10T428/25 , Y10T428/31855
摘要： An article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte and being free of salt crystals having a size greater than about 1 micrometer and free of voids having a size greater than about 100 nm, the article having no transverse dimension less than about 10,000 nm.
摘要翻译： 一种包含聚电解质络合物的制品，所述聚电解质复合物包含主要带正电荷的聚电解质和主要带负电荷的聚电解质的分子间共混物，并且不含具有大于约1微米的尺寸的盐晶体，并且没有尺寸大于 约100nm，该制品没有横向尺寸小于约10,000nm。
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20.发明授权公开(公告)号：US07629133B2
公开(公告)日：2009-12-08
申请号：US11764350
申请日：2007-06-18
申请人： Joseph B. Schlenoff
发明人： Joseph B. Schlenoff
IPC分类号： G01N21/76 , G01N33/53 , G01N33/544 , G01N33/545 , C12Q1/68
CPC分类号： G01N21/76 , C12Q1/6825 , G01N33/5438 , G01N2021/6432
摘要： A method for causing a membrane to become permeable to a first chemical species, in which the membrane is contacted with a solution comprising a second chemical species. The membrane comprises a polyelectrolyte complex film comprising a positively-charged polyelectrolyte and a negatively-charged polyelectrolyte. The second chemical species selectively interacts with the membrane, and selective interaction of the second chemical species with the membrane causes the membrane to become permeable to the first chemical species, thereby causing the first chemical species to permeate the membrane.
摘要翻译： 一种使膜变得可透过第一化学物质的方法，其中膜与包含第二化学物质的溶液接触。 膜包括聚电解质复合膜，其包含带正电的聚电解质和带负电荷的聚电解质。 第二化学物质选择性地与膜相互作用，并且第二化学物质与膜的选择性相互作用导致膜变得可渗透第一化学物质，从而导致第一化学物质渗透膜。
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