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11.4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US07709493B2
公开(公告)日:2010-05-04
申请号:US12468974
申请日:2009-05-20
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: C07D403/12 , A61K31/506 , A61P35/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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12.4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US07553840B2
公开(公告)日:2009-06-30
申请号:US11954000
申请日:2007-12-11
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: C07D239/34 , C07D403/12 , A61K31/506 , A61P9/02
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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公开(公告)号:US20120157484A1
公开(公告)日:2012-06-21
申请号:US13290261
申请日:2011-11-07
申请人: Arokiasamy DEVASAGAYARAJ , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人: Arokiasamy DEVASAGAYARAJ , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号: A61K31/505 , A61P1/00 , C07D401/04 , A61K31/506 , C07D239/47 , C07D239/42
CPC分类号: C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译: 公开了式I和II的化合物,以及包含它们的组合物及其用于治疗,预防和控制5-羟色胺介导的疾病和障碍的方法:
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14.4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds and Methods of Their Use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US20120041008A1
公开(公告)日:2012-02-16
申请号:US13162989
申请日:2011-06-17
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/506 , A61P1/04 , A61P1/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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15.4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds and Methods of Their Use 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶类化合物及其使用方法公开(公告)号:US20090286817A1
公开(公告)日:2009-11-19
申请号:US12468974
申请日:2009-05-20
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: C07D239/47 , A61K31/506 , A61P35/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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16.4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS AND METHODS OF THEIR USE 有权
标题翻译: 4-苯基-6-(2,2,2-三氟-1-苯基乙基)吡啶基化合物及其使用方法公开(公告)号:US20080153852A1
公开(公告)日:2008-06-26
申请号:US11954000
申请日:2007-12-11
申请人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人: Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号: A61K31/506 , C07D239/42 , A61P43/00
CPC分类号: A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译: 公开了式I化合物,以及包含它们的组合物及其用于治疗,预防和/或控制疾病和病症的方法:
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公开(公告)号:US07179827B2
公开(公告)日:2007-02-20
申请号:US11094237
申请日:2005-03-31
申请人: Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
发明人: Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
IPC分类号: A61K31/426 , A61K31/427 , C07D277/56 , C07D417/06
CPC分类号: C07D277/56 , C07D417/06
摘要: This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical compositions of these compounds, are also disclosed.
摘要翻译: 本发明涉及新的噻唑化合物。 还公开了使用这些化合物治疗,预防和治疗各种疾病或病症的方法,以及这些化合物的药物组合物。
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公开(公告)号:US20050282807A1
公开(公告)日:2005-12-22
申请号:US11094237
申请日:2005-03-31
申请人: Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
发明人: Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
IPC分类号: A61K31/426 , A61K31/427 , A61K31/454 , A61K31/5377 , C07D277/56 , C07D417/02 , C07D417/06
CPC分类号: C07D277/56 , C07D417/06
摘要: This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical compositions of these compounds, are also disclosed.
摘要翻译: 本发明涉及新的噻唑化合物。 还公开了使用这些化合物治疗,预防和治疗各种疾病或病症的方法,以及这些化合物的药物组合物。
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公开(公告)号:US20130040929A1
公开(公告)日:2013-02-14
申请号:US13642646
申请日:2011-05-06
申请人: Jeffrey J. Hale , Jinlong Jiang , Dong-Ming Shen , Zhi-Cai Shi , Min Shu , Zhicai Wu , Cangming Yang
发明人: Jeffrey J. Hale , Jinlong Jiang , Dong-Ming Shen , Zhi-Cai Shi , Min Shu , Zhicai Wu , Cangming Yang
IPC分类号: A61K31/506 , C07D401/04 , A61K31/454 , A61K31/4545 , A61P3/00 , C07D413/14 , A61K31/5377 , A61K31/4985 , A61P3/04 , A61P3/10 , C07D401/14 , A61K31/497
CPC分类号: C07D401/04 , C07D401/14
摘要: Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
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公开(公告)号:US07855291B2
公开(公告)日:2010-12-21
申请号:US11647517
申请日:2006-12-28
申请人: Hugh Alfred Burgoon, Jr. , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang
发明人: Hugh Alfred Burgoon, Jr. , Ramanaiah C. Kanamarlapudi , Iain Fraser Pickersgill , Zhi-Cai Shi , Wenxue Wu , Haiming Zhang
IPC分类号: C07D239/34 , C07D403/12 , A61K31/506 , A61K31/505 , A61P9/02
CPC分类号: A61K31/505 , C07D239/47
摘要: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed:
摘要翻译: 公开了用于制备取代的苯丙氨酸类化合物(例如式I)的中间体和合成方法:
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