公开(公告)号：US5308774A

公开(公告)日：1994-05-03

申请号：US625823

申请日：1990-12-11

申请人： Junkichi Miura ,  Masahito Ito ,  Yoshio Fujii ,  Hiroshi Satake ,  Kasumi Yoshida

发明人： Junkichi Miura ,  Masahito Ito ,  Yoshio Fujii ,  Hiroshi Satake ,  Kasumi Yoshida

IPC分类号： G01N30/06 ,  G01N21/64 ,  G01N30/04 ,  G01N30/14 ,  G01N30/24 ,  G01N30/74 ,  G01N30/88 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G01N33/88

CPC分类号： G01N30/24 ,  G01N35/00 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2035/00356 ,  G01N2035/00435 ,  G01N2035/1032 ,  G01N21/64 ,  G01N30/74 ,  G01N35/028 ,  G01N35/1004 ,  G01N35/109 ,  Y10T436/173845 ,  Y10T436/25125 ,  Y10T436/25625

摘要： Physiologically active substances contained in a biological sample not subjected to deproteinization can be converted to their derivatives at a high efficiency without being adversely affected by the protein present in the sample, and accordingly the analysis of said physiologically active substances in the form of said derivatives can be performed at a high precision.

摘要翻译： 未经脱蛋白化的生物样品中含有的生理活性物质可以高效率地转化为其衍生物，而不受样品中存在的蛋白质的不利影响，因此所述衍生物形式的所述生理活性物质的分析可以 以高精度执行。

公开(公告)号：US5277871A

公开(公告)日：1994-01-11

申请号：US5310

申请日：1993-01-19

申请人： Yoshio Fujii ,  Kasumi Yoshida ,  Junkichi Miura ,  Hiroshi Satake ,  Masahito Ito

发明人： Yoshio Fujii ,  Kasumi Yoshida ,  Junkichi Miura ,  Hiroshi Satake ,  Masahito Ito

IPC分类号： G01N21/64 ,  G01N30/06 ,  G01N30/88 ,  G01N35/00 ,  G01N35/10 ,  B01D15/08

CPC分类号： G01N35/0092 ,  G01N30/88 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2035/00356 ,  G01N2035/00435 ,  G01N2035/0093 ,  G01N2035/106 ,  G01N21/64 ,  G01N30/06 ,  G01N35/1004 ,  G01N35/109 ,  Y10T436/25625 ,  Y10T436/2575

摘要： The present invention provides a liquid chromatographic analyzer for analyzing a sample containing components for analysis by reacting the sample with a pre-labeling reagent to obtain a reaction mixture containing labeled components, concentrating the reaction mixture and separating the labeled components from each other, and detecting the separated labeled components by a detector, the steps of analysis being controlled to concurrently proceed by a control unit, thereby shortening the time for analysis per sample which analyzer includes: (a) a unit for storing samples containing components for analysis and a pre-labeling reagent for the components at a constant temperature, (b) a unit for reacting the sample with the pre-labeling reagent at a constant temperature to obtain a reaction mixture containing labeled components, (c) a unit for transferring one of the samples and the pre-labeling reagent from unit (a) to unit (b), (d) a unit for concentrating the reaction mixture and separating the labeled components from each other, (e) a unit for detecting the separated labeled components, and (f) a unit for controlling the steps of analysis to concurrently proceed, thereby shortening the time for analysis per sample.

摘要翻译： 本发明提供一种液相色谱分析仪，用于通过使样品与预标记试剂反应来分析含有分析成分的样品，以获得含有标记组分的反应混合物，浓缩反应混合物并将标记的组分彼此分离，并检测 通过检测器分离的标记的成分，分析的步骤被控制以由控制单元同时进行，从而缩短每个样品的分析时间，该分析仪包括：（a）用于存储包含用于分析的组分的样品的单元， （b）用于使样品与预标记试剂在恒定温度下反应以获得含有标记组分的反应混合物的单元，（c）用于转移样品之一的单元和 单元（a）至单位（b）的预标记试剂，（d）用于浓缩反应混合物的单元和分离 （e）用于检测分离的标记成分的单元，和（f）用于控制分析步骤同时进行的单元，从而缩短每个样品的分析时间。

公开(公告)号：US4708940A

公开(公告)日：1987-11-24

申请号：US473867

申请日：1983-03-10

申请人： Kasumi Yoshida ,  Nobuyoshi Takano ,  Naoya Ono

发明人： Kasumi Yoshida ,  Nobuyoshi Takano ,  Naoya Ono

IPC分类号： G01N33/48 ,  B04B5/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N21/07 ,  G01N21/11 ,  G01N37/00

CPC分类号： G01N35/0095 ,  B04B5/0421 ,  B04B2011/046 ,  G01N2035/00495 ,  G01N2035/00504 ,  G01N2035/1025 ,  G01N2035/1086 ,  Y10T436/111666

摘要： A clinical analyzer with an analyzing section having a reaction tube and photometer, and a sampling section having a sample transfer pipe and centrifugal separator which also serves as a sampler. Sample containers containing blood are set on a plurality of container holders through an aperture formed in the cover of the centrifugal separator. A rotor with the container holders mounted thereon is rotated at a low speed intermittently so that each of the container holders is positioned at the container setting position in a predetermined order in which a container holder which is not located adjacently to the previously positioned container holder is positioned next.Subsequently, the rotor is rotated at a high speed for a predetermined period so that the sample liquid in each sample container centrifugally separated. After the centrifugal separation, the rotor is rotated at a low speed intermittently so that the sample containers set on the container holders are positioned to the sample take-out position in the same order as in setting the sample containers. A pipe is inserted through a sample transfer hole formed in the cover of the centrifugal separator into the sample container, and the sample liquid is pumped up and transported to the analyzing section. This series of operations is repeated and a plurality of samples are measured for items of analysis by the photometer sequentially.

摘要翻译： 一种具有分析部分的临床分析器，其具有反应管和光度计，以及具有用作取样器的样品传送管和离心分离器的取样部分。 含有血液的样品容器通过形成在离心分离器的盖的孔中而设置在多个容器保持器上。 安装有容器保持器的转子以低速间歇地旋转，使得每个容器保持器以预定顺序定位在容器设置位置，在该预定顺序中，不位于与先前定位的容器保持器相邻的容器保持器 下一个定位。 随后，将转子高速旋转一定时间，使每个样品容器中的样品液体离心分离。 在离心分离之后，转子以低速间歇地旋转，使得设置在容器保持器上的样品容器以与设置样品容器相同的顺序位于样品取出位置。 将管道通过形成在离心分离器的盖的样品传送孔插入到样品容器中，并将样品液体泵送并输送到分析部。 重复该系列操作，并依次通过光度计测量多个样品的分析项目。