公开(公告)号：US09448241B2

公开(公告)日：2016-09-20

申请号：US13576124

申请日：2011-03-28

申请人： Jumpei Naito ,  Shuya Satoh ,  Manabu Komatsu ,  Hiroyuki Hashimoto

发明人： Jumpei Naito ,  Shuya Satoh ,  Manabu Komatsu ,  Hiroyuki Hashimoto

IPC分类号： G01N33/68 ,  H01J49/00

CPC分类号： G01N33/6851 ,  H01J49/00 ,  Y10T436/182

摘要： The problem to be solved by the present invention is to provide a method for treating a polypeptide including a cysteine residue for enhancing the sensitivity of detection thereof in mass spectrometry using charged particles. A mass spectrometry method for a polypeptide including a cysteine residue is provided which includes treating the polypeptide including a cysteine residue with a cyanation agent, treating the cyanated polypeptide with a base, and then desorption ionizing the base-treated polypeptides using charged particles for mass spectrometry.

摘要翻译： 本发明要解决的问题是提供一种用于在使用带电粒子的质谱法中治疗包含半胱氨酸残基的多肽以提高其检测灵敏度的方法。 提供了包括半胱氨酸残基的多肽的质谱法，其包括用氰化剂处理包含半胱氨酸残基的多肽，用碱处理氰化多肽，然后使用带电粒子对基质处理的多肽进行解吸，用于质谱法 。

公开(公告)号：US08754363B2

公开(公告)日：2014-06-17

申请号：US13575600

申请日：2011-01-31

申请人： Koichi Tanji ,  Manabu Komatsu ,  Hiroyuki Hashimoto

发明人： Koichi Tanji ,  Manabu Komatsu ,  Hiroyuki Hashimoto

IPC分类号： H01J49/26 ,  G06F17/14 ,  H01J49/00

CPC分类号： H01J49/0036 ,  H01J49/0004

摘要： A more effective noise reduction method is provided. In the method, when mass spectrum information having a spatial distribution is processed, the whole data is taken as three-dimensional data (positional information is stored in an xy plane, and spectral information is stored along a z-axis direction), and three-dimensional wavelet noise reduction is performed by applying preferable basis functions to a spectral direction and a peak distribution direction (in-plane direction).

摘要翻译： 提供了更有效的降噪方法。 在该方法中，当处理具有空间分布的质谱信息时，将整个数据作为三维数据（位置信息存储在xy平面中，并且光谱信息沿z轴方向存储），并且三个 通过对光谱方向和峰分布方向（面内方向）应用优选的基函数来进行维小波噪声降低。

公开(公告)号：US08704194B2

公开(公告)日：2014-04-22

申请号：US13083510

申请日：2011-04-08

申请人： Manabu Komatsu ,  Hiroyuki Hashimoto

发明人： Manabu Komatsu ,  Hiroyuki Hashimoto

IPC分类号： H01J49/14 ,  H01J49/10

CPC分类号： H01J49/06 ,  H01J49/0463

摘要： Target molecules in a sample can be detected at an improved sensitivity by means of a mass spectrometer. A sample with or without a matrix is placed on a substrate and irradiated with a converged and pulsed primary beam selected from an ion beam, a neutral particle beam or a laser beam. Secondary ions and neutral molecules are emitted along with protons from the irradiated point of the sample as an electric field is applied between the substrate and an extraction electrode disposed above the substrate. A proton-control electrode is arranged in axial symmetry with the trajectory of the primary beam. A voltage is applied thereto so that the generated electric field decelerates the flying protons to raise their adhering efficiency to the flying neutral molecules.

摘要翻译： 可以通过质谱仪以更高的灵敏度检测样品中的靶分子。 将具有或不具有矩阵的样品放置在基底上并用从离子束，中性粒子束或激光束中选择的会聚且脉冲的一次束照射。 随着电场施加在基板和设置在基板之上的引出电极之间，二次离子和中性分子与质子的辐射点一起被发射出来。 质子控制电极与主光束的轨迹轴对称。 施加电压使得所产生的电场使飞行质子减速，以提高它们对飞行中性分子的附着效率。

公开(公告)号：US08702415B2

公开(公告)日：2014-04-22

申请号：US12670414

申请日：2008-09-03

申请人： Hideto Monzen ,  Hiroyuki Hashimoto ,  Takuya Fujikawa ,  Hiroshi Hayashi ,  Tsuneo Imatani

发明人： Hideto Monzen ,  Hiroyuki Hashimoto ,  Takuya Fujikawa ,  Hiroshi Hayashi ,  Tsuneo Imatani

IPC分类号： B29C43/34

CPC分类号： B29C43/34 ,  B29B11/12 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14106 ,  B29B2911/14213 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/1444 ,  B29B2911/14466 ,  B29C31/048 ,  B29C43/08 ,  B29C47/0016 ,  B29C47/003 ,  B29C47/0042 ,  B29C2043/3466 ,  B29C2043/3676 ,  B29C2793/009 ,  B29K2067/00 ,  B29K2105/04 ,  B29K2105/258

摘要： The invention also provides for an apparatus for feeding molten resin, wherein the apparatus includes holding units each having a respective holding portion that is opened and closed to hold a molten resin that is discharged from an extrusion port of a die head of an extruder and is cut by a cutter while moving on a track, in which, after the respective holding portion transfers the molten resin from the extrusion port to a female mold, a side of the respective holding portion is opened and the molten resin is fed down to the female mold in a compression-molding machine, wherein a plurality of longitudinal grooves extending up and down are formed in an inner circumferential surface of the respective holding portion that holds the molten resin.

摘要翻译： 本发明还提供一种用于进料熔融树脂的设备，其中该设备包括保持单元，每个保持单元具有打开和关闭的相应的保持部分，以保持从挤出机的模头的挤出口排出的熔融树脂，并且是 在轨道上移动时由切割器切割，其中在各个保持部分将熔融树脂从挤出口转移到阴模之后，各个保持部分的一侧被打开，并且熔融树脂被向下馈送到母体 在压缩成型机中模具，其中在保持熔融树脂的各个保持部分的内周表面中形成有上下延伸的多个纵向槽。

公开(公告)号：US08415615B2

公开(公告)日：2013-04-09

申请号：US13351675

申请日：2012-01-17

申请人： Shuya Satoh ,  Hiroyuki Hashimoto

发明人： Shuya Satoh ,  Hiroyuki Hashimoto

IPC分类号： H01J49/26

CPC分类号： H01J49/142 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25875

摘要： Provided is a method that achieves both of soft ionization and high ionization efficiency of a substance to be analyzed at each measurement site without impairing a two-dimensional distribution state of the substance to be analyzed in desorption ionization mass spectrometry of a substance to be measured. By applying, to a substance to be analyzed, an ionization assisting reagent including an organic acid including a functional group represented by —(CF2)COOH and having a boiling point of 150° C. or more, and a polyhydric alcohol having a melting point of 20° C. or less and a boiling point of 150° C. or more at normal pressure, the organic acid, which is a component of the ionization assisting reagent, effectively donates a proton to the substance to be analyzed, thereby improving ionization efficiency, and the polyhydric alcohol, which is a component of the ionization assisting reagent, inhibits fragmentation.

摘要翻译： 本发明提供了一种能够在每个测量部位实现待分析物质的软电离和高电离效率的方法，而不会在待测物质的解吸电离质谱中损害待分析物质的二维分布状态。 通过将被分析物质应用于包含由 - （CF 2）COOH表示的官能团和沸点为150℃以上的有机酸的电离助剂和具有150℃以上的沸点的多元醇 在常压下为20℃以下，沸点为150℃以上，作为电离辅助剂的成分的有机酸能够有效地向待分析物质提供质子，从而提高离子化 作为电离助剂的成分的多元醇抑制分解。

公开(公告)号：US20110146202A1

公开(公告)日：2011-06-23

申请号：US13059750

申请日：2009-08-19

申请人： Tsuneo Imatani ,  Takeshi Iwashita ,  Hiroyuki Hashimoto ,  Hideto Monzen ,  Hotaka Fukabori ,  Hiroyuki Kondou

发明人： Tsuneo Imatani ,  Takeshi Iwashita ,  Hiroyuki Hashimoto ,  Hideto Monzen ,  Hotaka Fukabori ,  Hiroyuki Kondou

IPC分类号： B65B55/02 ,  B32B1/02 ,  B29C49/02

CPC分类号： B65B3/022 ,  B29B11/12 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14106 ,  B29B2911/14213 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/14413 ,  B29B2911/1444 ,  B29B2911/14466 ,  B29C43/08 ,  B29C43/34 ,  B29C43/42 ,  B29C49/02 ,  B29C49/64 ,  B29C2049/028 ,  B29D22/003 ,  B29K2067/00 ,  B29K2067/046 ,  B29K2105/258 ,  B29L2001/00 ,  B65B55/027 ,  B67B3/003 ,  B67C7/00 ,  B67C2003/227 ,  Y10T428/1397

摘要： [Problem] To realize a predetermined “aseptic level of the containers” without introducing a container sterilizing machine and to reduce the burden for adjusting the temperature of the preform.[Means for Solution] A metal mold for molding, wherein a space width (t2) of at least the body portion in the space width for forming a thickness of from the body portion to the bottom portion of the preform is set to lie in a range of 1.18 to 2.11 times as great as a space width (t1) for forming a thickness of an upper end portion of the mouth portion of the preform. At the time of the compression molding, the preform is taken out in the state of a high temperature from a compression-molding machine 31 and is fed to a bottle-producing unit C while maintaining the state of a high temperature. Further, the inner surfaces of a clean box I in which the units are placed and the outer surfaces of the units are sterilized, and the interior of the clean box I maintains a positive-pressure state with the filtered clean air. The bottle-producing unit C and a filling/sealing unit D are neighboring and directly coupled to each other in the same clean box, and are partitioned by a WBZ 54.

摘要翻译： [问题]在不引入容器消毒机的情况下实现预定的“无菌水平的容器”，并且减少调节预成型件的温度的负担。 [解决方案]一种用于模制的金属模具，其中，用于形成从预制件的主体部分到底部的厚度的空间宽度中的至少主体部分的空间宽度（t2）设置在 为形成预成型体的口部的上端部的厚度的空间宽度（t1）的1.18〜2.11倍的范围。 在压缩成型时，预成型体在高温状态下从压缩成型机31取出，并在保持高温状态的同时供给到制瓶单元C. 此外，其中放置单元的清洁箱I的内表面和单元的外表面被灭菌，并且清洁箱I的内部与被过滤的清洁空气保持正压状态。 制瓶单元C和填充/密封单元D相邻并且在相同的清洁盒中彼此直接耦合，并且被WBZ 54分隔开。

公开(公告)号：US07851749B2

公开(公告)日：2010-12-14

申请号：US12017584

申请日：2008-01-22

申请人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

发明人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

IPC分类号： H01J49/00

CPC分类号： H01J49/142

摘要： A method for obtaining information on a mass of an object by time-of-flight mass spectrometry. This method includes placing colloidal metal particles for promoting ionization of the object inside the object at a depth ranging from 0.1 nm to 100 nm in opposition to a primary beam for the ionization; irradiating the object with the primary beam selected from the group of ions, neutral particles, and electrons, which can be focused, pulsed, and are capable of scanning, and laser beams, which can be focused, pulsed, and are capable of scanning to ionize a constituent of the object and to allow the ionized constituent to fly out of the object; and obtaining information on the mass of the flying constituent of the object by time-of-flight mass spectrometry.

摘要翻译： 一种通过飞行时间质谱法获得物体质量信息的方法。 该方法包括将胶体金属颗粒放置在与离子化的主光束相反的0.1nm至100nm范围内的物体内部物体的离子化; 用可以被聚焦，脉冲和能够扫描的离子，中性粒子和电子组中选择的主要束照射物体，以及可以被聚焦，脉冲且能够扫描的激光束 电离物体的成分并使离子化成分从物体飞出; 并通过飞行时间质谱法获得关于物体飞行成分质量的信息。

公开(公告)号：US07795579B2

公开(公告)日：2010-09-14

申请号：US12120512

申请日：2008-05-14

申请人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

发明人： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

IPC分类号： B01D59/44

CPC分类号： H01J49/145

摘要： An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.

摘要翻译： 使用飞行时间质谱仪获取关于分析物的成分的质量的信息的信息获取方法，基于获得的关于质量的信息获得关于部件的分布状态的信息，包括以下步骤：（1）添加 对基底上的分析物的自反应物质，以促进组分的离子化; （2）在存在自反应物质的情况下用主光束照射分析物，从而电离成分并允许所得离子飞行; （3）使用飞行时间质谱仪获取关于飞行离子质量的信息; 和（4）基于关于质量的信息获得关于组件在基础上的分布状态的信息。

公开(公告)号：US20100221547A1

公开(公告)日：2010-09-02

申请号：US12161540

申请日：2006-12-21

申请人： Yoriko Nakayama ,  Hiroshi Kashiwagi ,  Hiroyuki Hashimoto ,  Kunimasa Hiyama

发明人： Yoriko Nakayama ,  Hiroshi Kashiwagi ,  Hiroyuki Hashimoto ,  Kunimasa Hiyama

IPC分类号： C09K11/06 ,  B32B9/04

CPC分类号： H01L51/5036 ,  H01L51/5016 ,  H01L51/5262 ,  Y10T428/31504

摘要： Provided is an organic electroluminescence element which is driven with a reduced drive voltage without deteriorating emission luminance and has a high power efficiency. The organic electroluminescence element having at least one light emitting layer is characterized in that two or more types of light emitting dopants having different emission colors are included in at least one light emitting layer, the concentration of all the light emitting dopants included in the light emitting layer is 5 Vol % or more, and the concentration of the light emitting dopant giving a main emission color among the light emitting dopants in the light emitting layer is 2 Vol % or less.

摘要翻译： 提供一种有机电致发光元件，其以降低的驱动电压驱动而不劣化发光亮度并且具有高功率效率。 具有至少一个发光层的有机电致发光元件的特征在于，在至少一个发光层中包含具有不同发光颜色的两种或更多种类型的发光掺杂剂，包含在所述发光层中的所有发光掺杂剂的浓度 层为5体积％以上，发光层中的发光掺杂物中的发光掺杂物的主要发光颜色的浓度为2体积％以下。

公开(公告)号：US20100209727A1

公开(公告)日：2010-08-19

申请号：US12670411

申请日：2008-09-03

申请人： Hideto Monzen ,  Hiroyuki Hashimoto ,  Hotaka Fukabori ,  Takuya Fujikawa ,  Hiroshi Hayashi ,  Tsuneo Imatani

发明人： Hideto Monzen ,  Hiroyuki Hashimoto ,  Hotaka Fukabori ,  Takuya Fujikawa ,  Hiroshi Hayashi ,  Tsuneo Imatani

IPC分类号： B28B11/12 ,  B29C49/50

CPC分类号： B29C31/048 ,  B29B11/12 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14106 ,  B29B2911/14213 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/1444 ,  B29B2911/14466 ,  B29C43/34 ,  B29C2043/3472 ,  B29K2105/258

摘要： [Problems] To provide an apparatus for feeding resin capable of extinguishing angular traces formed at both end portions of the cutter mark or of preventing the angular traces from extending up to the side wall of the body portion of the preform at the time of forming a preform.[Means for Solution] An apparatus for feeding molten resin to a compression-molding machine, including a holding unit 17 that rotates on a track, the holding unit 17 having a pair of holders 22 and 23 capable of holding and releasing the molten resin. When the molten resin is cut by a cutter, a linear cutter mark 29 is formed on the cut surface of the resin in a direction at right angles with the direction in which the molten resin is cut. Protruded portions 32 and 33 are formed on the inner circumferential surfaces of the holders 22 and 23 to deform the end portions of the cutter mark 29 toward the inside of the cutter mark when the molten resin is held by the pair of holders 22 and 23.

摘要翻译： [问题]提供一种用于进给树脂的装置，其能够消除形成在切割标记的两个端部处的角迹，或者在形成一个或多个切割标记时防止角迹沿着预成型体的主体部分的侧壁延伸 预制件。 [解决方案]一种用于将熔融树脂供给到压缩成型机的装置，包括在轨道上旋转的保持单元17，保持单元17具有能够保持和释放熔融树脂的一对保持器22和23。 当通过切割机切割熔融树脂时，在与切割熔融树脂的方向成直角的方向上在树脂的切割表面上形成线性切割痕迹29。 当保持器22和23的内圆周表面上形成有突起部分32和33，当熔融树脂被一对保持件22和23保持时，刀片标记29的端部朝切割器标记的内部变形。