Microscope apparatus based on laser scanning and operating method thereof

    公开(公告)号:US10761309B2

    公开(公告)日:2020-09-01

    申请号:US16659655

    申请日:2019-10-22

    Abstract: Disclosed is a laser scanning based microscope apparatus including a light source configured to output a laser signal, a scanning unit configured to scan a heating sample with a first laser signal corresponding to a portion of the output laser signal, and output an optical signal reflected from the sample by the scanning to a first detector, the first detector configured to generate a first electrical signal through the reflected optical signal, a second detector configured to generate a second electrical signal through a second laser signal corresponding to a remaining portion of the output laser signal, and a controller configured to acquire a thermal image of the sample by performing a frequency domain analysis based on the first electrical signal and a differential electrical signal.

    MICROSCOPE APPARATUS BASED ON LASER SCANNING AND OPERATING METHOD THEREOF

    公开(公告)号:US20200150413A1

    公开(公告)日:2020-05-14

    申请号:US16659655

    申请日:2019-10-22

    Abstract: Disclosed is a laser scanning based microscope apparatus including a light source configured to output a laser signal, a scanning unit configured to scan a heating sample with a first laser signal corresponding to a portion of the output laser signal, and output an optical signal reflected from the sample by the scanning to a first detector, the first detector configured to generate a first electrical signal through the reflected optical signal, a second detector configured to generate a second electrical signal through a second laser signal corresponding to a remaining portion of the output laser signal, and a controller configured to acquire a thermal image of the sample by performing a frequency domain analysis based on the first electrical signal and a differential electrical signal.

    Solid immersion lens holder for high resolution optical microscope

    公开(公告)号:US10281707B2

    公开(公告)日:2019-05-07

    申请号:US15387622

    申请日:2016-12-21

    Abstract: Provided is a solid immersion lens (SIL) holder for optical axis precision correction of a high resolution optical microscope, equipped with a SIL and an objective lens barrel equipped with a plurality of objective lenses, the SIL holder comprising: a circular flange providing in the middle of the objective lens barrel to be coupled to the SIL holder; a coupling flange formed at one end portion thereof and coupled to the circular flange; a conical tube formed at the other end portion thereof, the SIL being mounted onto a lower end portion of the conical tube, wherein the SIL holder comprises an optical axis adjusting part which adjusts such that the central axis of the SIL approaches the central axis of an objective lens, and the SIL holder comprises an extension/contraction adjusting part which allows the SIL to be very close to a measurement surface of a specimen.

    Image sensor comprising a digital-alloy microlens array integrated with sensor array, and manufacturing method thereof
    14.
    发明授权
    Image sensor comprising a digital-alloy microlens array integrated with sensor array, and manufacturing method thereof 有权
    图像传感器包括与传感器阵列集成的数字合金微透镜阵列及其制造方法

    公开(公告)号:US09093576B2

    公开(公告)日:2015-07-28

    申请号:US14056915

    申请日:2013-10-17

    Abstract: The present invention relates to an image sensor comprising a microlens array, and to a manufacturing method thereof. The method of the present invention includes gradually increasing the aluminum composition ratio of a compound semiconductor as the latter gradually gets farther from a substrate, to enable a microlens-forming layer to grow, and making the oxidation rate of the region adjacent to the substrate slower and the oxidation rate of the region farther from the substrate faster, making the interface between the oxidized region and the unoxidized region into a lens shape after the completion of oxidation. The thus-made lens is integrated into an image sensor. The present invention reduces costs for manufacturing image sensors in which a microlens is integrated, increases the signal-to-noise ratio and resolution of the image sensor, and achieves improved sensitivity.

    Abstract translation: 本发明涉及一种包括微透镜阵列的图像传感器及其制造方法。 本发明的方法包括逐渐增加化合物半导体的铝组成比,随着后者从衬底逐渐变得越远,以使微透镜形成层生长,并且使与邻近衬底的区域的氧化速率变慢 并且距离衬底更远的区域的氧化速率更快,使氧化区域和未氧化区域之间的界面在氧化完成后成为透镜形状。 这样制成的镜头被集成到图像传感器中。 本发明降低了其中集成微透镜的图像传感器的制造成本,增加了图像传感器的信噪比和分辨率,并且实现了改进的灵敏度。

    Apparatus and method for acquiring fluorescence image

    公开(公告)号:US10386299B2

    公开(公告)日:2019-08-20

    申请号:US15660166

    申请日:2017-07-26

    Abstract: Provided is a fluorescence image acquisition apparatus for acquiring fluorescence images and phase images using optical signals that are modulated at the same frequency and that have different time delays. The fluorescence image acquisition apparatus may include a light source configured to generate, at different time delays, a plurality of optical signals that are modulated at the same frequency, an illuminator configured to control paths of the plurality of modulated optical signals so that the plurality of modulated optical signals are illuminated onto a sample including a plurality of fluorescent materials, a photodetector configured to detect a plurality of fluorescence signals that are emitted from the plurality of fluorescent materials, respectively, and a controller configured to acquire a plurality of fluorescence images and a plurality of phase images from the plurality of detected fluorescence signals.

    Apparatus for fixing solid immersion lens
    18.
    发明授权
    Apparatus for fixing solid immersion lens 有权
    固定浸没透镜的装置

    公开(公告)号:US09575282B2

    公开(公告)日:2017-02-21

    申请号:US14389443

    申请日:2013-09-13

    CPC classification number: G02B7/023 G01Q60/22 G02B7/025 G02B7/04 G02B27/56

    Abstract: Provided is an apparatus for fixing a solid immersion lens (SIL) in an optical system. The apparatus includes a first adapter; a second adapter screw-coupled to the inner surface of the first adapter and screw-coupled to the outer surface of a third adapter to pressurize a first O-ring; the third adapter screw-coupled to the inner surfaces of the second adapter and a fourth adapter; the fourth adapter screw-coupled to the outer surface of the third adapter to pressurize a second O-ring; the first and second O-rings elastically fixing an outer surface of a barrel of an infrared ray (IR) objective lens; and an SIL holder mounting the SIL onto the first adapter.

    Abstract translation: 提供了一种用于将固体浸没透镜(SIL)固定在光学系统中的装置。 该装置包括第一适配器; 第二适配器,其螺纹联接到所述第一适配器的内表面,并且螺纹连接到第三适配器的外表面以对第一O形环加压; 所述第三适配器螺纹连接到所述第二适配器的内表面和第四适配器; 所述第四适配器螺纹连接到所述第三适配器的外表面以加压第二O形环; 所述第一和第二O形环弹性地固定红外线(IR)物镜的镜筒的外表面; 以及将SIL安装到第一适配器上的SIL保持架。

    Optical fiber array probe imaging system integrated with endoscope
    19.
    发明授权
    Optical fiber array probe imaging system integrated with endoscope 有权
    光纤阵列探头成像系统与内窥镜相结合

    公开(公告)号:US08700135B2

    公开(公告)日:2014-04-15

    申请号:US13708329

    申请日:2012-12-07

    Abstract: Provided is an imaging system which includes an optical fiber array probe unit integrated with an endoscope unit, thereby simultaneously measuring structural information and functional information of a sample. The optical fiber array probe unit includes an optical fiber array probe integrated with lenses including an optical fiber lens with a lens surface of a predetermined radius of curvature in which one ends of optical fibers are integrally connected with each other by heating a predetermined region including the one ends of two of the optical fibers using a heating means, as an optical fiber array probe integrated lens on which the light transmitted from the light source is incident and which guides light reflected from the sample, and a detector for selectively detecting the light transmitted from the optical fiber array probe integrated with lenses in a predetermined range of wavelength.

    Abstract translation: 提供了一种成像系统,其包括与内窥镜单元集成的光纤阵列探针单元,从而同时测量样品的结构信息和功能信息。 光纤阵列探针单元包括与透镜组合的光纤阵列探针,该透镜包括具有预定曲率半径的透镜表面的光纤透镜,其中光纤的一端通过加热包括 使用加热装置的两根光纤的一端作为光纤阵列探针集成透镜,其中从光源透射的光入射到该光纤阵列探针集成透镜,并且其引导从样品反射的光;以及检测器,用于选择性地检测透射的光 从与预定波长范围的透镜集成的光纤阵列探针。

    IMAGE SENSOR COMPRISING A DIGITAL-ALLOY MICROLENS ARRAY, AND MANUFACTURING METHOD THEREOF
    20.
    发明申请
    IMAGE SENSOR COMPRISING A DIGITAL-ALLOY MICROLENS ARRAY, AND MANUFACTURING METHOD THEREOF 有权
    包含数字合金微型阵列的图像传感器及其制造方法

    公开(公告)号:US20140042579A1

    公开(公告)日:2014-02-13

    申请号:US14056915

    申请日:2013-10-17

    Abstract: The present invention relates to an image sensor comprising a microlens array, and to a manufacturing method thereof. The method of the present invention includes gradually increasing the aluminum composition ratio of a compound semiconductor as the latter gradually gets farther from a substrate, to enable a microlens-forming layer to grow, and making the oxidation rate of the region adjacent to the substrate slower and the oxidation rate of the region farther from the substrate faster, making the interface between the oxidized region and the unoxidized region into a lens shape after the completion of oxidation. The thus-made lens is integrated into an image sensor. The present invention reduces costs for manufacturing image sensors in which a microlens is integrated, increases the signal-to-noise ratio and resolution of the image sensor, and achieves improved sensitivity.

    Abstract translation: 本发明涉及一种包括微透镜阵列的图像传感器及其制造方法。 本发明的方法包括逐渐增加化合物半导体的铝组成比,随着后者从衬底逐渐变得越远,以使微透镜形成层生长,并且使与邻近衬底的区域的氧化速率变慢 并且距离衬底更远的区域的氧化速率更快,使氧化区域和未氧化区域之间的界面在氧化完成后成为透镜形状。 这样制成的镜头被集成到图像传感器中。 本发明降低了其中集成微透镜的图像传感器的制造成本,增加了图像传感器的信噪比和分辨率,并且实现了改进的灵敏度。

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