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公开(公告)号：US11461338B2
公开(公告)日：2022-10-04
申请号：US14392323
申请日：2014-06-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nivedita Sumi Majumdar , Harrison Leong , Theodore E. Straub , David Hoard
IPC: G06F16/2457 , G06F16/248 , G16B45/00
Abstract: A method for generating a data visualization is provided. The method includes receiving a plurality of data points related to fluorescent emissions values from a plurality of reaction sites. The fluorescent emission values include information for a first type of dye and a second type of dye. The method further includes displaying a first portion of the plurality of data points related to the first type of dye in a representation of location of the plurality of reaction sites, and displaying a second portion of the plurality of data points related to the second type of dye in the representation. The method further includes displaying the first portion of the plurality of data points in a scatter plot display. The scatter plot shows fluorescent values related to the first dye on the y-axis and fluorescent values related to the second dye on the x-axis. The method includes displaying the second portion of the plurality of data points in the scatter plot display.
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公开(公告)号：US11447815B2
公开(公告)日：2022-09-20
申请号：US16228304
申请日：2018-12-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Shiaw-Min Chen , David W. Ruff , Harrison Leong
IPC: C12Q1/6844 , G16B25/00 , G16B40/00 , G16B25/20 , G16B40/10
Abstract: Various embodiments of methods for analyzing proximity binding assay (PBA) data are disclosed. Proximity binding assays as a class of analyses offer the advantages of the sensitivity and specificity of biorecognition binding, along with the exponential signal amplification offered by a variety of oligonucleotide amplification reactions, such as the polymerase chain reaction (PCR). However, as various proximity binding assays have reaction kinetics governed by an additional step of the binding of a biorecognition probe (BRP) with a target molecule, there is a need for methods for the analysis of PBA data that are particularly suited to the unique characteristics of such data.
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公开(公告)号：US11238958B2
公开(公告)日：2022-02-01
申请号：US14807764
申请日：2015-07-23
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Harrison Leong , Nivedita Sumi Majumdar
Abstract: System and methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Additionally, various embodiments of an interactive graphical user interface (GUI) may provide an end-user with ready analysis of large sets of data representing a plurality of samples. In various embodiments of an interactive GUI, an end-user may be provided with a synchronized display of tabular and graphical sample data determined by an initial analysis according to a statistical model of a PDF. Such a synchronized display may enable an end-user to readily identify sample data for a subsequent analysis based on user input.
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Patent Agency Ranking
公开(公告)号：US10340029B2
公开(公告)日：2019-07-02
申请号：US15144369
申请日：2016-05-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nivedita Sumi Majumdar , Harrison Leong , Ruoyun Wu
IPC: G06T11/20 , G16B40/00 , G16B45/00 , G06F3/0482 , G06F3/0484
Abstract: The present teachings relate to embodiments of systems and methods for the analysis of melt curve data for a plurality of samples. According to various embodiments, a melting temperature (Tm) may be determined across a range of different types of protein melt curve data, having variability over a plurality of analytical attributes in order to accommodate the complexity of protein melt curve data. The combination of a plurality of samples, coupled with the complexity of the data gives rise for a need to process the data in a manner that readily facilitates end-user to analysis of the data. Various embodiments of an interactive graphical user interface (GUI) according to the present teachings provide for rapid and sequential changes that may be made by an end user to displayed protein melt curve data to allow such analysis.
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公开(公告)号：US11417037B2
公开(公告)日：2022-08-16
申请号：US16937634
申请日：2020-07-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Harrison Leong , Nivedita Sumi Majumdar , Jeffrey A. Marks , Theodore E. Straub , Ryan J. Talbot , Kevin S. Bodner , David Hoard
Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.
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公开(公告)号：US20210147946A1
公开(公告)日：2021-05-20
申请号：US17091092
申请日：2020-11-06
Applicant: Life Technologies Corporation
Inventor： Charles Wendell Higdon, III , Harrison Leong , Charles Baudo , Carole Bornarth , Edgar Schreiber
IPC: C12Q1/6886 , C12Q1/6844 , G16B30/10 , G16B40/10
Abstract: Systems, primers, kits, and methods for detecting microsatellite instability in a biological sample are described. Signal data is received from a capillary electrophoresis genetic analysis instrument, wherein the signal data is measured from fluorescence of fragments comprising nucleic acid sequences amplified from the biological sample via polymerase chain reaction (PCR). The nucleic acid sequences correspond to a plurality of different microsatellite loci and are obtained using a plurality of PCR primers configured to flank a plurality of microsatellite loci of a biological sample. When the PCR primers and the biological sample are combined and subjected to PCR amplification, fluorescently labeled DNA fragments are generated comprising the plurality of microsatellite loci. Fluorescent data obtained from the plurality of fluorescently labelled microsatellite loci are used to classify microsatellite instability of the biological sample.
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公开(公告)号：US20160321398A1
公开(公告)日：2016-11-03
申请号：US15144369
申请日：2016-05-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Nivedita Sumi Majumdar , Harrison Leong , Ruoyun Wu
IPC: G06F19/26 , G06F3/0482 , G06F3/0484 , G06T11/20
CPC classification number: G16B45/00 , G06F3/0482 , G06F3/04847 , G06T11/206 , G06T2200/24 , G16B40/00
Abstract: The present teachings relate to embodiments of systems and methods for the analysis of melt curve data for a plurality of samples. According to various embodiments, a melting temperature (Tm) may be determined across a range of different types of protein melt curve data, having variability over a plurality of analytical attributes in order to accommodate the complexity of protein melt curve data. The combination of a plurality of samples, coupled with the complexity of the data gives rise for a need to process the data in a manner that readily facilitates end-user to analysis of the data. Various embodiments of an interactive graphical user interface (GUI) according to the present teachings provide for rapid and sequential changes that may be made by an end user to displayed protein melt curve data to allow such analysis.
Abstract translation: 本教导涉及用于分析多个样品的熔体曲线数据的系统和方法的实施例。 根据各种实施方案，可以在不同类型的蛋白质熔融曲线数据的范围内确定熔解温度（Tm），其具有多个分析属性的变异性，以适应蛋白质熔融曲线数据的复杂性。 多个样本的组合以及数据的复杂性导致需要以容易促进最终用户分析数据的方式处理数据。 根据本发明的交互式图形用户界面（GUI）的各种实施例提供了可以由终端用户进行快速和顺序改变以显示蛋白质熔解曲线数据以允许这种分析。
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公开(公告)号：US20150356241A1
公开(公告)日：2015-12-10
申请号：US14759496
申请日：2014-01-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Harrison Leong
Abstract: In one exemplary embodiment, a computer-implemented method for determining a genetic result from a biological sample is provided. The method includes receiving nucleic acid amplification data of a biological sample, by a processor, from a biological instrument. The method further includes storing translation data, in a memory. The translation data includes a pattern of assay values associated with possible genetic results. The method further includes comparing the translation data with the nucleic acid amplification data, by the processor, to generate the genetic result of the biological sample. Moreover, the method includes displaying the genetic result, on a display, to a user.
Abstract translation: 在一个示例性实施例中，提供了一种用于确定生物样品的遗传结果的计算机实现的方法。 该方法包括通过处理器从生物仪器接收生物样品的核酸扩增数据。 该方法还包括将翻译数据存储在存储器中。 翻译数据包括与可能的遗传结果相关联的测定值的模式。 该方法还包括通过处理器比较翻译数据与核酸扩增数据，以产生生物样品的遗传结果。 此外，该方法包括将显示器上的遗传结果显示给用户。
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