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公开(公告)号:US20220002007A1
公开(公告)日:2022-01-06
申请号:US17481605
申请日:2021-09-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Jeremy K. Larsen , Patrick L. Draper , Brandon M. Knudsen
Abstract: A fluid manifold system includes a first manifold having portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. The fluid flow path of the first manifold includes: a primary flow path communicating with the fluid inlet of the first manifold; and a plurality of spaced apart secondary flow paths that branch off of the primary flow path. Each secondary flow path has a first end communicating with the primary flow path and an opposing second end, each secondary flow path having a diameter that is smaller than a diameter of the primary flow path. The fluid manifold system also includes a plurality of tubular connectors with each tubular connector being secured to the first manifold at the second end of a corresponding one of the secondary flow paths.
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公开(公告)号:US10328404B2
公开(公告)日:2019-06-25
申请号:US15596952
申请日:2017-05-16
Applicant: Life Technologies Corporation
Inventor: Michael E. Goodwin , Nephi D. Jones , Jeremy K. Larsen
IPC: B01F15/00 , B01F3/04 , C12M1/00 , B01F5/04 , B01F13/02 , B01F7/00 , B01F7/22 , C12M1/04 , C12M1/12 , B01F11/00
Abstract: A container system includes a collapsible bag having an interior surface at least partially bounding a chamber, the chamber being adapted to hold a fluid. A sparger is disposed within the chamber of the bag, the sparger bounding a compartment and having an inside edge that encircles an opening passing through the sparger. At least a portion of the sparger is gas permeable. A tubular member is coupled to the sparger and is in communication with the compartment. A shaft passes into the chamber of the bag and through the opening of the sparger. A mixing element is secured to the shaft and is disposed within the chamber of the bag.
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公开(公告)号:US10301585B2
公开(公告)日:2019-05-28
申请号:US15193962
申请日:2016-06-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Jeremy K. Larsen , Jon Q. Coleman , David S. Rowley
Abstract: A filter assembly for separating microcarriers from a fluid medium includes a collapsible container bounding a sterile compartment adapted to hold a fluid. An inlet port is attached to the container through which fluid flows into the compartment. An outlet port is attached to the container through which fluid flows out of the compartment. A filter is disposed within the compartment, the filter dividing the compartment into an inlet chamber that is fluidly coupled with the inlet port and an outlet chamber that is fluidly coupled with the outlet port, the filter allowing a medium to pass therethrough but preventing microcarriers disposed in the medium from passing therethrough.
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公开(公告)号:US09682353B2
公开(公告)日:2017-06-20
申请号:US15265022
申请日:2016-09-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Nephi D. Jones , Jeremy K. Larsen
IPC: C12M1/04 , B01F15/00 , B01F3/04 , C12M1/00 , B01F5/04 , B01F13/02 , B01F7/00 , B01F7/22 , C12M1/12
CPC classification number: B01F15/0085 , B01F3/04269 , B01F3/04439 , B01F3/04829 , B01F5/04 , B01F7/00341 , B01F7/22 , B01F11/0082 , B01F13/0255 , B01F2003/04276 , B01F2003/04297 , B01F2003/04312 , B01F2003/04326 , B01F2003/04361 , B01F2003/04382 , B01F2003/04397 , B01F2215/0073 , C12M23/14 , C12M23/20 , C12M23/26 , C12M27/04 , C12M29/06 , C12M37/00
Abstract: A container system includes a bag comprised of one or more sheets of flexible polymeric material, the bag having an interior surface at least partially bounding a chamber, the chamber being adapted to hold a fluid. A flexible sparging sheet is secured to the interior surface of the bag so that a compartment is formed between the interior surface of the bag and the sparging sheet, at least a portion of the sparging sheet allowing gas to pass therethrough. A tubular port or tube is secured to the bag so that a passage bounded by the tubular port or tube communicates with the compartment. A mixing element is disposed within the chamber of the bag, the mixing element being spaced apart from the flexible sparging sheet.
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公开(公告)号:US20170001160A1
公开(公告)日:2017-01-05
申请号:US15265022
申请日:2016-09-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Nephi D. Jones , Jeremy K. Larsen
IPC: B01F15/00 , B01F7/00 , B01F7/22 , C12M1/04 , B01F13/02 , C12M1/00 , C12M1/12 , B01F3/04 , B01F5/04
CPC classification number: B01F15/0085 , B01F3/04269 , B01F3/04439 , B01F3/04829 , B01F5/04 , B01F7/00341 , B01F7/22 , B01F11/0082 , B01F13/0255 , B01F2003/04276 , B01F2003/04297 , B01F2003/04312 , B01F2003/04326 , B01F2003/04361 , B01F2003/04382 , B01F2003/04397 , B01F2215/0073 , C12M23/14 , C12M23/20 , C12M23/26 , C12M27/04 , C12M29/06 , C12M37/00
Abstract: A container system includes a bag comprised of one or more sheets of flexible polymeric material, the bag having an interior surface at least partially bounding a chamber, the chamber being adapted to hold a fluid. A flexible sparging sheet is secured to the interior surface of the bag so that a compartment is formed between the interior surface of the bag and the sparging sheet, at least a portion of the sparging sheet allowing gas to pass therethrough. A tubular port or tube is secured to the bag so that a passage bounded by the tubular port or tube communicates with the compartment. A mixing element is disposed within the chamber of the bag, the mixing element being spaced apart from the flexible sparging sheet.
Abstract translation: 容器系统包括由一层或多层柔性聚合材料构成的袋,该袋具有至少部分地限定室的内表面,该室适于保持流体。 将柔性喷射片固定到袋的内表面,使得在袋的内表面和喷射片之间形成隔室,至少一部分鼓泡片允许气体通过。 管状端口或管被固定到袋上,使得由管状端口或管限定的通道与隔室连通。 混合元件设置在袋的室内,混合元件与柔性喷射片间隔开。
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公开(公告)号:US09475012B2
公开(公告)日:2016-10-25
申请号:US15041335
申请日:2016-02-11
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael D. Goodwin , Nephi D. Jones , Jeremy K. Larsen
CPC classification number: B01F15/0085 , B01F3/04269 , B01F3/04439 , B01F3/04829 , B01F5/04 , B01F7/00341 , B01F7/22 , B01F11/0082 , B01F13/0255 , B01F2003/04276 , B01F2003/04297 , B01F2003/04312 , B01F2003/04326 , B01F2003/04361 , B01F2003/04382 , B01F2003/04397 , B01F2215/0073 , C12M23/14 , C12M23/20 , C12M23/26 , C12M27/04 , C12M29/06 , C12M37/00
Abstract: A container assembly includes a container at least partially bounding a chamber and having a wall with an opening extending therethrough. A tubular stem bounds a passageway and outwardly projects from the wall of the container so that the passageway communicates with the opening. A sparger includes a tubular member having a first end and an opposing second end and an interior surface bounding a passage extending therebetween. A gas permeable sparging member is secured to the first end of the tubular member so that gas passing through the tubular member from the second end passes out through the sparging sheet. A second flange encircles and radially outwardly projects from the tubular member, the second flange being secured to the stem so that at least a portion of the tubular member is disposed within the passageway of the tubular stem.
Abstract translation: 容器组件包括容器,该容器至少部分地限定室并具有壁,所述壁具有贯穿其中的开口。 管状茎状物限定通道并从容器的壁向外突出,使得通道与开口连通。 分布器包括具有第一端和相对的第二端的管状构件和限定在其之间延伸的通道的内表面。 气体可渗透的喷射构件被固定到管状构件的第一端,使得从第二端通过管状构件的气体通过喷射板。 第二凸缘环绕并从管状构件径向向外突出,第二凸缘固定到杆,使得管状构件的至少一部分设置在管状杆的通道内。
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公开(公告)号:US09259692B2
公开(公告)日:2016-02-16
申请号:US14663068
申请日:2015-03-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Nephi D. Jones , Jeremy K. Larsen
CPC classification number: B01F15/0085 , B01F3/04269 , B01F3/04439 , B01F3/04829 , B01F5/04 , B01F7/00341 , B01F7/22 , B01F11/0082 , B01F13/0255 , B01F2003/04276 , B01F2003/04297 , B01F2003/04312 , B01F2003/04326 , B01F2003/04361 , B01F2003/04382 , B01F2003/04397 , B01F2215/0073 , C12M23/14 , C12M23/20 , C12M23/26 , C12M27/04 , C12M29/06 , C12M37/00
Abstract: A container system includes a bag having of one or more sheets of flexible polymeric material, the bag having an interior surface at least partially bounding a chamber, the chamber being adapted to hold a fluid. A flexible sparging sheet is secured to the interior surface of the bag so that a compartment is formed between the interior surface of the bag and the sparging sheet, at least a portion of the sparging sheet allowing gas to pass therethrough. A tubular port or tube is secured with the bag or the sparging sheet so that a passage bounded by the tubular port or tube communicates with the compartment.
Abstract translation: 容器系统包括具有一层或多层柔性聚合物材料的袋,该袋具有至少部分地限定室的内表面,该室适于容纳流体。 将柔性喷射片固定到袋的内表面,使得在袋的内表面和喷射片之间形成隔室,至少一部分鼓泡片允许气体通过。 用袋或喷射片固定管状端口或管,使得由管状端口或管限定的通道与隔室连通。
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公开(公告)号:US20150259082A1
公开(公告)日:2015-09-17
申请号:US14728717
申请日:2015-06-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Michael E. Goodwin , Jeremy K. Larsen , Patrick L. Draper , Brandon M. Knudsen
CPC classification number: B65B1/04 , A61J1/10 , B65B3/003 , B65B3/02 , B65B3/04 , B65B51/02 , B65B51/225
Abstract: A fluid manifold system includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold.
Abstract translation: 流体歧管系统包括歧管,歧管具有至少部分相对的柔性片焊接在一起以在其间形成流体流动通道,与流体流动路径连通的流体入口。 多个接收容器与歧管的流体流动路径流体连通,每个接收容器围绕隔室。 接收容器可以通过将相对的柔性片的第二部分焊接在一起而与歧管形成一体,或者可以包括联接到歧管的分开的容器。
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公开(公告)号:US11840684B2
公开(公告)日:2023-12-12
申请号:US17186553
申请日:2021-02-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor: Jeremy K. Larsen , Jon Q. Coleman , David S. Rowley
CPC classification number: C12M29/04 , B01D29/13 , B01D29/27 , B01D35/027 , B01D61/147 , B01D63/06 , C12M23/14 , C12M23/26 , C12M25/16 , C12M33/14 , C12M47/02
Abstract: A method for separating microcarriers from a medium includes transferring a suspension that includes medium, microcarriers and cells into a compartment of a filter assembly. The filter assembly includes: a container having an interior surface bounding the compartment; and a filter having a tubular stem with an encircling sidewall extending between a first end and an opposing second end, the first end being secured to the interior surface of the container and the second end projecting into the compartment of the container, a plurality of openings extend through the sidewall of the stem that are large enough to allow the medium and cells to pass therethrough while preventing the microcarriers from passing therethrough. The medium and cells within the compartment are allowed to pass through the plurality of openings of the filter while the microcarriers are retained within the compartment of the container.
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公开(公告)号:US11591556B2
公开(公告)日:2023-02-28
申请号:US16863702
申请日:2020-04-30
Inventor: Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
IPC: C12M1/00 , B01F27/07 , B01F27/88 , B01F27/91 , B01F33/00 , B01F35/51 , B01F35/513 , C12M1/06 , C12M1/12 , B01F101/44
Abstract: A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.
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