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公开(公告)号：US10144968B2
公开(公告)日：2018-12-04
申请号：US15200588
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Steven M. Menchen , Alfred Lui , Guobing Xiang , Synne Larsen
IPC: C12Q1/68 , C12Q1/6876 , C12Q1/6869 , C12Q1/6874
Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network. Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
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公开(公告)号：US09422384B2
公开(公告)日：2016-08-23
申请号：US14745815
申请日：2015-06-22
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Hofslokken Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US09139665B2
公开(公告)日：2015-09-22
申请号：US14082336
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete I. Modahl , Nini H. Kjus , Astrid E. Molteberg , Diem Tran , Jo Aaserud , Talha M. Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F8/32 , C08F8/34 , C08F6/24 , C07F7/18 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C12Q1/68
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09067954B2
公开(公告)日：2015-06-30
申请号：US14081263
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini H. Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08L9/00 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US09062080B2
公开(公告)日：2015-06-23
申请号：US14081224
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini H. Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F236/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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Patent Agency Ranking
公开(公告)号：US12122859B2
公开(公告)日：2024-10-22
申请号：US18101785
申请日：2023-01-26
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C07F7/18 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F130/08 , C08F220/58 , C08F222/38 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/414 , C08F220/60
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F222/385 , C08F230/085 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , C08F220/603 , C08F2800/20 , C08J2343/04 , Y10T428/2982 , C08F8/12 , C08F257/02 , C08F8/34 , C08F8/12 , C08F257/02 , C12Q1/686 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543 , C08F257/02 , C08F230/085 , C08F8/12 , C08F230/085 , C08F8/34 , C08F8/12 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F220/603 , C08F230/085 , C08F212/36 , C08F230/085 , C08F222/102
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US11572427B2
公开(公告)日：2023-02-07
申请号：US17165039
申请日：2021-02-02
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F220/60
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US10407676B2
公开(公告)日：2019-09-10
申请号：US14964060
申请日：2015-12-09
Applicant: LIFE TECHNOLOGIES CORPORATION , THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS
Inventor： Thomas Poehmerer , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US10202473B2
公开(公告)日：2019-02-12
申请号：US15005420
申请日：2016-01-25
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09487603B2
公开(公告)日：2016-11-08
申请号：US14970241
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C08J9/20 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/68 , C12P19/34 , G01N27/414
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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