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公开(公告)号：US10246533B2
公开(公告)日：2019-04-02
申请号：US14970192
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of monomer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09868826B2
公开(公告)日：2018-01-16
申请号：US15200533
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Steven M. Menchen , Talha M. Gokmen , Pontus Lundberg , Prasanna Krishnan Thwar , Alfred Lui , Lily Lu , Wolfgang Hinz , Lene Husaboe , Elisabeth Breivold , Astrid Evenroed Molteberg , Synne Larsen
IPC: C08J3/075 , C08F220/58 , C08F8/12 , C08F220/70 , C08F230/08
CPC classification number: C08J3/075 , C08F8/12 , C08F220/58 , C08F220/70 , C08F2230/085 , C08J2333/26 , C08F222/38
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：US20160186166A1
公开(公告)日：2016-06-30
申请号：US14964060
申请日：2015-12-09
Applicant: Life Technologies Corporation , Thermo Fisher Scientific Geneart Gmbh , Life Technologies As
Inventor： Thomas POEHMERER , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson , Xiquan Liang
CPC classification number: C12N15/101 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L3/502761 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C5/026 , B03C2201/26 , C25B3/10 , C25B9/18 , C25B11/04 , C25B15/02
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20200010827A1
公开(公告)日：2020-01-09
申请号：US16518099
申请日：2019-07-22
Applicant: THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas Poehmerer , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson , Xiquan Liang
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US10189956B2
公开(公告)日：2019-01-29
申请号：US15871863
申请日：2018-01-15
Applicant: Life Technologies AS , Life Technologies Corporation
Inventor： Geir Fonnum , Steven M. Menchen , M. Talha Gokmen , Pontus Lundberg , Prasanna Krishnan Thwar , Alfred Lui , Lily Lu , Wolfgang Hinz , Lene Husaboe , Elisabeth Breivold , Astrid Evenroed Molteberg , Synne Larsen
IPC: C08F8/12 , C08J3/075 , C08F220/58 , C08F220/70 , C08F230/08
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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Patent Agency Ranking
公开(公告)号：US20170002410A1
公开(公告)日：2017-01-05
申请号：US15200588
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Steven M. Menchen , Alfred Lui , Guobing Xiang , Synne Larsen
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6869 , C12Q1/6874 , C12Q2525/197 , C12Q2527/125 , C12Q2565/607 , C12Q2565/629
Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
Abstract translation: 聚合物基质，例如聚合物涂层或聚合物水凝胶网络，包括羧基部分，其可以用作受体或分析物分子可以连接到的缀合位点。 在一个实例中，聚合物底物包括具有链烷酸部分或其衍生物的聚丙烯酰胺聚合物网络，其可以与羧基活化化合物反应，以在聚丙烯酰胺网络上提供活化的链烷酸酯部分。胺封端的核酸可以与活化的链烷酸酯部分反应 通过烷基酰胺部分将核酸捕获到聚合物网络。
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公开(公告)号：US10947333B2
公开(公告)日：2021-03-16
申请号：US16259963
申请日：2019-01-28
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , Muhammed Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09828453B2
公开(公告)日：2017-11-28
申请号：US15212532
申请日：2016-07-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Hofslokken Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US09139666B2
公开(公告)日：2015-09-22
申请号：US14082368
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete I. Modahl , Nini H. Kjus , Astrid E. Molteberg , Diem Tran , Jo Aaserud , Talha M. Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C12Q1/68 , C08F8/34 , C07F7/18 , C08F6/24 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
Abstract translation: 形成颗粒的方法包括在水性悬浮液中的分散相中聚合具有疏水保护基团的亲水性单体的多个聚合单元，从而形成包含多个疏水保护基团的聚合物颗粒。 该方法还包括将聚合物颗粒转化为亲水性颗粒。
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公开(公告)号：US10676790B2
公开(公告)日：2020-06-09
申请号：US16206957
申请日：2018-11-30
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Steven M. Menchen , Alfred Lui , Guobing Xiang , Synne Larsen
IPC: C12Q1/68 , C12Q1/6876 , C12Q1/6874 , C12Q1/6869 , C08J7/14 , C12Q1/6853
Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network. Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
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