公开(公告)号：US20090035165A1

公开(公告)日：2009-02-05

申请号：US11833493

申请日：2007-08-03

申请人： James Chang

发明人： James Chang

IPC分类号： F04B43/12

CPC分类号： F04B43/1292 ,  F04B43/0072 ,  F04B43/0081

摘要： The present invention provides an addressable multi-channel peristaltic pump. According to the invention, this pump design allows for selection and operation of one or more pump heads on a drive shaft, while locking other non-selected pump heads in a stationary position. It is possible to operate the multi-channel pump using a limited number of motors, preferably two motors: a selector motor and a dispense motor. Thus, the pump provides for pumping or dispensing of one or more fluids without the need for multiple pumps. Likewise, compared with typical single motor multi-channel systems, where all pump heads on the drive shaft must rotate at the same time, the present invention provides for selective dispensing of one or more fluids. The pumps of the present invention are suitable for any multiple fluid transfer application, including in automated multi-channel reagent dispensing systems, such as nucleic acid purification systems.

摘要翻译： 本发明提供一种可寻址的多通道蠕动泵。 根据本发明，该泵设计允许在驱动轴上选择和操作一个或多个泵头，同时将其它未选择的泵头锁定在静止位置。 可以使用有限数量的电动机，优选两个电动机来操作多通道泵：选择器电动机和分配电动机。 因此，泵提供一个或多个流体的泵送或分配，而不需要多个泵。 同样，与典型的单电动机多通道系统相比，驱动轴上的所有泵头必须同时旋转，本发明提供了一种或多种流体的选择性分配。 本发明的泵适用于任何多种流体转移应用，包括在自动多通道试剂分配系统中，例如核酸纯化系统。

公开(公告)号：US20080070834A1

公开(公告)日：2008-03-20

申请号：US11940652

申请日：2007-11-15

申请人： James Chang ,  Orest Olejnik ,  Bruce Firestone

发明人： James Chang ,  Orest Olejnik ,  Bruce Firestone

IPC分类号： A61K38/13 ,  A61P27/02

CPC分类号： A61K47/44 ,  A61K9/0048 ,  A61K9/107 ,  A61K38/13 ,  Y10S514/912 ,  Y10S514/975

摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

摘要翻译： 本文公开了包含约0.001％至约0.4％的环孢菌素A，表面活性剂和比重为0.8至0.95的油的组合物。

公开(公告)号：US20070216213A1

公开(公告)日：2007-09-20

申请号：US11381706

申请日：2006-05-04

申请人： James Chang

发明人： James Chang

IPC分类号： A47C7/22 ,  D04B1/18 ,  D04B7/16 ,  D04B11/12 ,  D04B21/14

CPC分类号： A47C7/282 ,  A47C5/04 ,  Y10T442/413

摘要： An apparatus having a fabric and method of forming thereof. The fabric's load bearing surface for supporting a load, comprising: at least one layer(s) (Ln) wherein n=0, −1, −2, . . . −i, wherein n=0 represents the at least one layer(s) (Ln) of the load bearing surface that contacts the load. An n=−1, −2, . . . −i, represents successive underlying at least one layer(s) (Ln) of the load bearing surface. An n=−i, represents a bottom underlying at least one layer(s) (Ln). The fabric consists essentially of a polyurethane fiber and a fiber that is chemically different from the polyurethane fiber, and wherein the fabric has been stretched to the point just before encountering the Young's Modulus. The method comprising: cutting the fabric to a predetermined pattern; and stretching the fabric to the point just before encountering the Young's Modulus.

摘要翻译： 一种具有织物的装置及其形成方法。 用于支撑负载的织物的承载表面，包括：至少一个层（L n n n），其中n = 0，-1，-2。 。 。 -i，其中n = 0表示与负载接触的承载表面的至少一个层（L n n N）。 n = -1，-2，。 。 。 -i表示承载表面的连续的下层的至少一层（L n n N）。 n = -i表示至少一层（L）下的底层。 织物基本上由聚氨酯纤维和与聚氨酯纤维在化学上不同的纤维组成，并且其中织物已经被拉伸到遇到杨氏模量之前的点。 该方法包括：将织物切割成预定图案; 并将织物拉伸到刚刚遇到杨氏模量之前。

公开(公告)号：US20070117507A1

公开(公告)日：2007-05-24

申请号：US11580228

申请日：2006-10-13

申请人： Myles Wakayama ,  Dana Laub ,  Frank Carr ,  Afshin Mellati ,  David Ho ,  Hsiang-Bin Lee ,  Chun-Ying Chen ,  James Chang ,  Lawrence Burns ,  Young Shin ,  Patrick Pai ,  Iconomos Koullias ,  Ron Lipka ,  Luke Steigerwald ,  Alexandre Kral

发明人： Myles Wakayama ,  Dana Laub ,  Frank Carr ,  Afshin Mellati ,  David Ho ,  Hsiang-Bin Lee ,  Chun-Ying Chen ,  James Chang ,  Lawrence Burns ,  Young Shin ,  Patrick Pai ,  Iconomos Koullias ,  Ron Lipka ,  Luke Steigerwald ,  Alexandre Kral

IPC分类号： H04H1/00 ,  H04B1/28

CPC分类号： H03H11/04 ,  H03D3/008 ,  H03D7/1441 ,  H03D7/1458 ,  H03D7/1483 ,  H03D7/165 ,  H03D2200/0025 ,  H03D2200/0043 ,  H03D2200/0047 ,  H04B1/30

摘要： A direct conversion satellite tuner is fully integrated on a common substrate. The integrated tuner receives an RF signal having a plurality of channels and down-converts a selected channel directly to baseband for further processing. The integrated tuner includes on-chip local oscillator generation, tunable baseband filters, and DC Offset cancellation. The integrated tuner can be implemented in a completely differential I/Q configuration for improved electrical performance. The entire direct conversion satellite tuner can be fabricated on a single semiconductor substrate using standard CMOS processing, with minimal off-chip components. The tuner configuration described herein is not limited to processing TV signals, and can be utilized to down-convert other RF signals to an IF frequency or baseband.

摘要翻译： 直接转换卫星调谐器完全集成在公共基板上。 集成调谐器接收具有多个信道的RF信号，并将所选择的信道直接下变频到基带用于进一步处理。 集成调谐器包括片上本地振荡器产生，可调谐基带滤波器和DC偏移消除。 集成调谐器可以以完全差分的I / Q配置来实现，以改善电气性能。 整个直接转换卫星调谐器可以使用标准CMOS处理在单个半导体衬底上制造，具有最小的片外部件。 这里描述的调谐器配置不限于处理TV信号，并且可以用于将其它RF信号下变频到IF频率或基带。

公开(公告)号：US20060233860A1

公开(公告)日：2006-10-19

申请号：US11394765

申请日：2006-03-31

申请人： James Chang ,  Lon Spada ,  Wendy Blanda ,  Werhner Orilla ,  James Burke ,  Patrick Hughes

发明人： James Chang ,  Lon Spada ,  Wendy Blanda ,  Werhner Orilla ,  James Burke ,  Patrick Hughes

IPC分类号： A61K31/498 ,  A61F2/00

CPC分类号： A61K9/0051 ,  A61K31/498 ,  A61L27/18 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/604 ,  A61L2430/16 ,  Y02A50/401 ,  C08L67/04

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

公开(公告)号：US20060198866A1

公开(公告)日：2006-09-07

申请号：US11378401

申请日：2006-03-16

申请人： James Chang ,  Robert Cleek ,  Edward Cully ,  Michael Vonesh

发明人： James Chang ,  Robert Cleek ,  Edward Cully ,  Michael Vonesh

IPC分类号： A61F2/06

CPC分类号： A61L31/10 ,  A61L27/34 ,  C08L101/04

摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used. The desirable mechanical characteristics are surprising given the absence of cross-linking monomers and curing agents that would otherwise render such materials inadequately biocompatible. The perfluoroalkylvinylether may be perfluoromethylvinylether, perfluoroethylvinylether or perfluoropropylvinylether.

摘要翻译： 一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。 含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。 这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。 此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。 该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。 鉴于不存在交联单体和固化剂，否则将使得这些材料生物相容性不足，理想的机械特性令人惊奇。 全氟烷基乙烯基醚可以是全氟甲基乙烯基醚，全氟乙基乙烯基醚或全氟丙基乙烯基醚。

公开(公告)号：US20060041091A1

公开(公告)日：2006-02-23

申请号：US11227658

申请日：2005-09-14

申请人： James Chang ,  Jack Hegenbarth ,  Jon Moseley ,  Huey Wu

发明人： James Chang ,  Jack Hegenbarth ,  Jon Moseley ,  Huey Wu

IPC分类号： C08F16/24

CPC分类号： C08F214/18

摘要： An improved elastomeric material is described comprising an essentially noncross-linkable amorphous copolymer of tetrafluoroethylene (TFE) and perfluoromethyl vinyl ether (PMVE) which is both a thermoplastic and exhibits exceptional mechanical properties. This material is particularly suitable for use in ultra-clean environments, and particularly for use in an implantable device, since it does not contain contaminants that previous thermoset TFE/PMVE copolymers have required. Among the improved properties of the present invention are excellent biocompatibility, high matrix tensile strength, high clarity, high abrasion resistance, high purity, adequate elasticity, and ease of processing due to the thermoplastic, and noncross-linkable structure of the copolymer. The material of the present invention is also a high strength bonding agent particularly suited for bonding porous PTFE to itself or to other porous substances at room or elevated temperatures.

公开(公告)号：US20060008443A1

公开(公告)日：2006-01-12

申请号：US11225230

申请日：2005-09-12

申请人： James Chang ,  Teresa Kuan

发明人： James Chang ,  Teresa Kuan

IPC分类号： A61K31/74

CPC分类号： A61K9/0048 ,  A61K47/38 ,  Y10S514/912

摘要： Ophthalmic compositions include an ophthalmically acceptable carrier component, for example, an aqueous-based carrier, and a plurality of polyanionic component portions having different molecular weights. In one embodiment, the polyanionic component includes a first polyanionic component portion having a first molecular weight; and a second polyanionic component portion having a different second molecular weight. Each of the first and second polyanionic component portions is present in an amount effective to provide lubrication to an eye when the composition is administered to an eye. Methods of making and using such compositions are also disclosed.

公开(公告)号：US20050277584A1

公开(公告)日：2005-12-15

申请号：US10865638

申请日：2004-06-09

申请人： Walter Tien ,  Richard Graham ,  James Chang

发明人： Walter Tien ,  Richard Graham ,  James Chang

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/355 ,  A61K38/13 ,  A61K47/22

CPC分类号： A61K9/0048 ,  A61K9/08 ,  A61K31/355 ,  A61K38/13 ,  A61K2300/00

摘要： A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an aqueous solution, and wherein no hydrophilic organic solvent is present at a concentration greater than half of that of the cyclosporin is also disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for ophthalmic use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for parenteral use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.

摘要翻译： 包含治疗有效浓度的环孢菌素和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是水溶液，并且其中没有亲水性有机溶剂的浓度大于环孢菌素浓度的一半的浓度 。 一种组合物，其包含治疗有效浓度的环孢菌素A和有效量的维生素E生育酚聚乙二醇琥珀酸酯，其中所述组合物是旨在用于眼用的水性液体溶液，并且其中没有亲水性有机溶剂以质量浓度存在 大于或等于环孢菌素的浓度。 一种组合物，其包含治疗有效浓度的环孢菌素A和有效量的维生素E生育酚聚乙二醇琥珀酸酯，其中所述组合物是用于肠胃外使用的水性液体溶液，并且其中没有亲水性有机溶剂以质量浓度存在 大于或等于环孢菌素的浓度。 使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

公开(公告)号：US20050064567A1

公开(公告)日：2005-03-24

申请号：US10667430

申请日：2003-09-23

申请人： Jiunn-Jyi Lay ,  James Chang ,  Kuo-Shu Fan

发明人： Jiunn-Jyi Lay ,  James Chang ,  Kuo-Shu Fan

IPC分类号： C12P1/04 ,  C12P3/00

CPC分类号： C12P3/00 ,  Y02E50/343

摘要： Anaerobic hydrogen-producing process includes steps of producing hydrogen from organic waste under anaerobic condition, utilizing microorganisms, and of purifying hydrogen directly useable as fuel, and then transformed to become electric energy by a fuel cell.

摘要翻译： 厌氧生氢方法包括在厌氧条件下利用微生物从有机废弃物中生产氢气，以及纯化直接用作燃料的氢，然后通过燃料电池转化为电能的步骤。