公开(公告)号：US20240361322A1

公开(公告)日：2024-10-31

申请号：US18538543

申请日：2023-12-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574 ,  A61K39/395

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11600373B2

公开(公告)日：2023-03-07

申请号：US16555271

申请日：2019-08-29

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566 ,  G01N33/569 ,  G01N33/68 ,  G16H20/40 ,  G01T1/02 ,  G01T1/00 ,  G01N27/327 ,  G01N35/00

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11525825B2

公开(公告)日：2022-12-13

申请号：US16564208

申请日：2019-09-09

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin ,  David Routenberg

IPC: C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844 ,  G01N33/543

Abstract: The present invention is directed to kits for improving assay specificity and performance in binding assays.

公开(公告)号：US10908157B2

公开(公告)日：2021-02-02

申请号：US15440191

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/58

Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.

公开(公告)号：US20200378966A1

公开(公告)日：2020-12-03

申请号：US16836245

申请日：2020-03-31

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  Mikayla Higgins ,  John Kenten ,  George Sigal

IPC: G01N33/564

Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US10114015B2

公开(公告)日：2018-10-30

申请号：US14208040

申请日：2014-03-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  John Kenten

IPC: C12Q1/68 ,  G01N33/543 ,  C12Q1/682 ,  C12Q1/6844 ,  C12Q1/6837 ,  C12Q1/6848

Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

公开(公告)号：US20170160281A1

公开(公告)日：2017-06-08

申请号：US15440136

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20140315742A1

公开(公告)日：2014-10-23

申请号：US14348275

申请日：2012-09-28

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566

CPC classification number: G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Abstract translation: 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。

公开(公告)号：US20250020662A1

公开(公告)日：2025-01-16

申请号：US18617868

申请日：2024-03-27

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  John Kenten ,  Galina Nikolenko

IPC: G01N33/68

Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11971418B2

公开(公告)日：2024-04-30

申请号：US17169805

申请日：2021-02-08

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  John Kenten ,  Galina Nikolenko

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2800/347 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.