公开(公告)号：US20240123034A1

公开(公告)日：2024-04-18

申请号：US17768514

申请日：2020-10-15

Applicant: ModernaTX, Inc. ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Eric Yi-Chun Huang ,  Jared Iacovelli ,  Seymour De Picciotto ,  Sze-Wah Tse ,  Laurie Kenney ,  Katherine Olson ,  Howard Gendelman ,  Lee R. Mosley

IPC: A61K38/19 ,  A61K9/51 ,  A61K31/7115 ,  A61P25/16

CPC classification number: A61K38/193 ,  A61K9/5123 ,  A61K31/7115 ,  A61P25/16

Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.

公开(公告)号：US20230130155A1

公开(公告)日：2023-04-27

申请号：US17759687

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-Chun Huang ,  Sze-Wah Tse ,  Seymour De Picciotto ,  Laurie Kenney

IPC: A61K9/51 ,  A61K31/7105 ,  B82Y5/00 ,  A61P37/06

Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising metabolic reprogramming molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding metabolic reprogramming polypeptides, e.g., IDO, TDO, AMPK, AhR, ALDH1A2, HMOX1, CD73 or CD39. The LNP compositions of the present disclosure can reprogram myeloid and/or dendritic cells, suppress T cells and/or induce immune tolerance in vivo.

公开(公告)号：US11576961B2

公开(公告)日：2023-02-14

申请号：US16493986

申请日：2018-03-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kerim Babaoglu ,  Jessica Anne Flynn ,  Lan Zhang ,  David Nickle

IPC: A61K39/145 ,  A61K39/00

Abstract: The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

公开(公告)号：US11364292B2

公开(公告)日：2022-06-21

申请号：US16898268

申请日：2020-06-10

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K48/00 ,  A61K9/14 ,  A61K9/00 ,  C07K16/28 ,  C07K14/005 ,  C07K16/10 ,  C07K14/18 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51 ,  A61K39/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20210187097A1

公开(公告)日：2021-06-24

申请号：US16493986

申请日：2018-03-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kerim Babaoglu ,  Jessica Anne Flynn ,  Lan Zhang ,  David Nickle

IPC: A61K39/145

Abstract: The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

公开(公告)号：US11027025B2

公开(公告)日：2021-06-08

申请号：US14903869

申请日：2014-07-11

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Eric Yi-Chun Huang ,  Tirtha Chakraborty

IPC: A61K48/00 ,  C12N15/90 ,  C12N9/16 ,  C12N15/11

Abstract: The present invention relates to compositions comprising and methods of using synthetic polynucleotides, e.g., modified mRNA, encoding CRISPR related proteins including dCAS9 and synthetic sgRNAs targeting a gene of interest.

公开(公告)号：US20200368344A1

公开(公告)日：2020-11-26

申请号：US16898268

申请日：2020-06-10

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/00 ,  C07K16/28 ,  C07K14/005 ,  C07K16/10 ,  A61K9/14 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20200289638A1

公开(公告)日：2020-09-17

申请号：US16850519

申请日：2020-04-16

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20190008946A1

公开(公告)日：2019-01-10

申请号：US16136386

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20180008694A1

公开(公告)日：2018-01-11

申请号：US15674591

申请日：2017-08-11

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/513 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/575 ,  C12N2770/24034 ,  C12N2770/24134 ,  C12N2770/36134 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/392

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.