公开(公告)号：US20060147974A1

公开(公告)日：2006-07-06

申请号：US11345126

申请日：2006-02-01

申请人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

发明人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C07K14/525 ,  C12N5/06

CPC分类号： C07K14/525 ,  A01K2217/05

摘要： The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

摘要翻译： 本发明提供了编码果蝇DmTNF多肽的新型多核苷酸，其片段和同系物。 本发明还涉及编码两种果蝇DmTNF变体，DmTNFv1和DmTNFv2多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 除了遗传修饰果蝇或培养细胞以表达或错误表达DmTNF，DmTNFv1或DmTNFv2的方法之外，本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及这种修饰的昆虫或细胞用于表征DmTNF活性，鉴定涉及调节TNF，表征TNF信号传导途径和/或鉴定DmTNF活性调节剂的TNF-样基因和/或基因的用途。

公开(公告)号：US20080014593A1

公开(公告)日：2008-01-17

申请号：US11897997

申请日：2007-08-31

申请人： Lauren Barber ,  Angela Cacace ,  John Feder ,  Thomas Nelson ,  Chandra Ramanathan ,  Rolf-Peter Ryseck ,  Michael Neubauer ,  Michael Kornacker

发明人： Lauren Barber ,  Angela Cacace ,  John Feder ,  Thomas Nelson ,  Chandra Ramanathan ,  Rolf-Peter Ryseck ,  Michael Neubauer ,  Michael Kornacker

IPC分类号： C12Q1/68

CPC分类号： G01N33/5008 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/6893 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2510/00 ,  G01N2800/347 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20070196897A1

公开(公告)日：2007-08-23

申请号：US11071761

申请日：2005-03-03

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20050208526A1

公开(公告)日：2005-09-22

申请号：US10994987

申请日：2004-11-22

申请人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

发明人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K14/72 ,  C12N20060101 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68

CPC分类号： C07K14/723

摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20050130286A1

公开(公告)日：2005-06-16

申请号：US10029345

申请日：2001-12-20

申请人： Donald Jackson ,  Chandra Ramanathan ,  John Feder ,  Gabe Mintier ,  Liana Lee ,  Thomas Nelson ,  Nathan Siemers ,  David Bol ,  Suzanne Suchard ,  Gary Schieven ,  Joshua Finger ,  C. Todderrud ,  Donna Bassolino ,  Stanley Krystek ,  Dana Banas ,  Patrick McAtee

发明人： Donald Jackson ,  Chandra Ramanathan ,  John Feder ,  Gabe Mintier ,  Liana Lee ,  Thomas Nelson ,  Nathan Siemers ,  David Bol ,  Suzanne Suchard ,  Gary Schieven ,  Joshua Finger ,  C. Todderrud ,  Donna Bassolino ,  Stanley Krystek ,  Dana Banas ,  Patrick McAtee

IPC分类号： A61K38/00 ,  A61K38/43 ,  A61K48/00 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12 ,  A61P15/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N15/09 ,  C12N15/55 ,  C12P21/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/573 ,  G01N33/68 ,  G06F19/16 ,  C07H21/04

CPC分类号： G06F19/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/03048 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2500/04 ,  Y02A90/26

摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20070259373A1

公开(公告)日：2007-11-08

申请号：US11809905

申请日：2007-05-31

申请人： Gena Whitney ,  Gregory Opiteck ,  Leah Garulacan ,  Chandra Ramanathan ,  Murray McKinnon ,  Kelly Bennett ,  Lauren Barber ,  Angela Cacace ,  Zenta Tsuchihashi ,  John Feder

发明人： Gena Whitney ,  Gregory Opiteck ,  Leah Garulacan ,  Chandra Ramanathan ,  Murray McKinnon ,  Kelly Bennett ,  Lauren Barber ,  Angela Cacace ,  Zenta Tsuchihashi ,  John Feder

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C07K14/705 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/574 ,  G01N33/6884 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/122

摘要： The present invention describes a G-protein coupled receptor (GPCR) family member newly identified as being modified, e.g., phosphorylated, and associated with tyrosine phosphorylated activation complexes, following exposure of cells to smoke from tobacco burning substances, namely, cigarette smoke. This GPCR protein is RAI-3, which was first found to be phosphorylated in cells treated with cigarette smoke and to be associated with other proteins activated in cigarette smoke treated cells by virtue of the present invention. Because cigarette smoke is considered to be a major causative factor of chronic obstructive pulmonary disease (COPD) and disorders and conditions related thereto, the RAI-3 protein is newly provided as a cellular drug target for screening, discovering, and identifying modulators for the treatment and/or prevention of COPD and its related disorders and conditions, such as emphysema and chronic bronchitis. In accordance with the present invention RAI-3 modulators, e.g., agonists and antagonists, can be used as therapeutics in the treatment of COPD and numerous other diseases and disorders that are associated with regulation of NF-κB and/or its associated or interacting signaling molecules. This invention further provides SNPs of RAI-3, e.g., for determining COPD association in individuals.

摘要翻译： 本发明描述了在将烟草暴露于烟草燃烧物质（即香烟烟雾）之后，新鉴定为被修饰，例如磷酸化并与酪氨酸磷酸化活化复合物相关的G-蛋白偶联受体（GPCR）家族成员。 该GPCR蛋白是RAI-3，其首先被发现在用香烟烟雾处理的细胞中被磷酸化并且与通过本发明在香烟烟雾处理的细胞中活化的其它蛋白质相关联。 由于香烟烟雾被认为是慢性阻塞性肺疾病（COPD）的主要致病因素及与之相关的病症和病症，所以RAI-3蛋白质作为筛选，发现和鉴定调节剂治疗的细胞药物靶点被新提供 和/或预防COPD及其相关疾病和病症如肺气肿和慢性支气管炎。 根据本发明，RAI-3调节剂（例如激动剂和拮抗剂）可用作治疗COPD和许多与调节NF-κB和/或其相关或相互作用的信号相关的其它疾病和病症 分子。 本发明还提供RAI-3的SNP，例如用于确定个体中的COPD关联。

公开(公告)号：US20060292625A1

公开(公告)日：2006-12-28

申请号：US11511141

申请日：2006-08-28

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HLLRCR-1多肽的新型多核苷酸，其片段和同源物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型HLLRCR-1多肽应用于诊断，治疗和/或预防与这些多肽，特别是神经系统疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20060257918A1

公开(公告)日：2006-11-16

申请号：US11486332

申请日：2006-07-13

申请人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

发明人： Chandra Ramanathan ,  John Feder ,  Gabriel Mintier

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/723

摘要： The present invention provides novel polynucleotides encoding HGPRBMY5v1 and HGPRBMY5v2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY5v1 and HGPRBMY5v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY5v1和HGPRBMY5v2多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY5v1和HGPRBMY5v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20060177903A1

公开(公告)日：2006-08-10

申请号：US11377517

申请日：2006-03-16

申请人： Chandra Ramanathan ,  John Feder

发明人： Chandra Ramanathan ,  John Feder

IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/705

摘要： The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

公开(公告)号：US20060084140A1

公开(公告)日：2006-04-20

申请号：US10237813

申请日：2002-09-06

申请人： Chandra Ramanathan ,  Shuba Gopal ,  Gabriel Mintier ,  John Feder

发明人： Chandra Ramanathan ,  Shuba Gopal ,  Gabriel Mintier ,  John Feder

IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY39多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY39多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。