公开(公告)号：US20060147974A1

公开(公告)日：2006-07-06

申请号：US11345126

申请日：2006-02-01

申请人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

发明人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C07K14/525 ,  C12N5/06

CPC分类号： C07K14/525 ,  A01K2217/05

摘要： The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

摘要翻译： 本发明提供了编码果蝇DmTNF多肽的新型多核苷酸，其片段和同系物。 本发明还涉及编码两种果蝇DmTNF变体，DmTNFv1和DmTNFv2多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 除了遗传修饰果蝇或培养细胞以表达或错误表达DmTNF，DmTNFv1或DmTNFv2的方法之外，本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及这种修饰的昆虫或细胞用于表征DmTNF活性，鉴定涉及调节TNF，表征TNF信号传导途径和/或鉴定DmTNF活性调节剂的TNF-样基因和/或基因的用途。

公开(公告)号：US20050227283A1

公开(公告)日：2005-10-13

申请号：US11142736

申请日：2005-06-01

申请人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

发明人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

IPC分类号： C07K14/525 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/09

CPC分类号： C07K14/525 ,  A01K2217/05

摘要： The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

摘要翻译： 本发明提供了编码果蝇DmTNF多肽的新型多核苷酸，其片段和同系物。 本发明还涉及编码两种果蝇DmTNF变体，DmTNFv1和DmTNFv2多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 除了遗传修饰果蝇或培养细胞以表达或错误表达DmTNF，DmTNFv1或DmTNFv2的方法之外，本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及这种修饰的昆虫或细胞用于表征DmTNF活性，鉴定涉及调节TNF，表征TNF信号传导途径和/或鉴定DmTNF活性调节剂的TNF-样基因和/或基因的用途。

公开(公告)号：US20060160128A1

公开(公告)日：2006-07-20

申请号：US11386902

申请日：2006-03-22

申请人： John Feder ,  Chandra Ramanathan ,  Gabe Mintier

发明人： John Feder ,  Chandra Ramanathan ,  Gabe Mintier

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/88

CPC分类号： C12Q1/6883 ,  C12N9/78 ,  C12Q2600/158

摘要： This invention provides a novel isolated polynucleotide sequence, called ADARP1 (adenosine deaminase related protein 1), that displays significant homology to the adenosine deaminase (ADA) gene. Also provided is the amino acid sequence of the ADARP1 polypeptide encoded by the polynucleotide of the invention. The RNA for this novel gene is found in variety of tissues, with higher levels observed in the heart, testes, and skeletal muscle compared with others tested. Based on amino acid sequence homology, the ADARP1 protein will likely display the catalytic activity characteristic of ADA. This newly found ADARP1 gene and its encoded product may be useful in the treatment of immunodeficiencies, including severe combined immunodeficiency disease (SCID) and other ADA deficiencies, treatment of male reproductive disorders, testicular disorders and musclo-skeletal disorders.

公开(公告)号：US20050227238A1

公开(公告)日：2005-10-13

申请号：US10800249

申请日：2004-03-12

申请人： Chandra Ramanathan ,  John Feder

发明人： Chandra Ramanathan ,  John Feder

IPC分类号： A61K38/16 ,  C07H21/04 ,  C07K14/705 ,  C07K16/28 ,  C12N20060101 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68

CPC分类号： C07K14/705

摘要： The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY74多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY74多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20080064094A1

公开(公告)日：2008-03-13

申请号：US11890963

申请日：2007-08-08

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

IPC分类号： C12N5/00 ,  C07K1/00 ,  C07K16/00

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20050203048A1

公开(公告)日：2005-09-15

申请号：US11107572

申请日：2005-04-15

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04 ,  C07K14/82 ,  G01N33/574

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/53 ,  C07K14/47

摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20050148016A1

公开(公告)日：2005-07-07

申请号：US11070456

申请日：2005-03-02

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier ,  David Bol ,  Donald Hawken

IPC分类号： A61K38/00 ,  C07K14/705 ,  C12Q1/68 ,  C07H21/04 ,  C07K16/28

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20050064491A1

公开(公告)日：2005-03-24

申请号：US10948493

申请日：2004-09-23

申请人： Steven Dworetzky ,  Chandra Ramanathan ,  Joanne Trojnacki ,  Christopher Boissard ,  Valentin Gribkoff

发明人： Steven Dworetzky ,  Chandra Ramanathan ,  Joanne Trojnacki ,  Christopher Boissard ,  Valentin Gribkoff

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K35/76 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P11/06 ,  A61P17/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P35/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  G01N33/15 ,  G01N37/00 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： An isolated polynucleotide encoding a novel potassium channel polypeptide, KCNQ5, that is expressed primarily in brain and skeletal muscle is described. The new polypeptide has been cloned and isolated from a human brain cDNA library and is a member the KCNQ family of potassium channels. The provided human KCNQ5 nucleic acid sequence and encoded polypeptide can be employed for diagnostic, screening and therapeutic uses. Moreover, the hKCNQ5 polypeptide can be used to assay for KCNQ5 potassium channel modulators, which can be utilized in the treatment of neurological, neurophysiological, neuropsychological and neuroaffective diseases, conditions and disorders, including, but not limited to, acute and chronic pain, migraine, acute stroke, dementia, vascular dementia, trauma, epilepsy, amyelotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson's Disease, learning and cognitive disorders, and neurophysiological disorders including anxiety disorders, depression, bipolar disorders, sleep disorders, addiction, and eating disorders.

摘要翻译： 描述了编码主要在脑和骨骼肌中表达的新型钾通道多肽KCNQ5的分离的多核苷酸。 新的多肽已经从人脑cDNA文库克隆和分离，并且是钾通道KCNQ家族的成员。 提供的人类KCNQ5核酸序列和编码的多肽可用于诊断，筛选和治疗用途。 此外，hKCNQ5多肽可用于测定KCNQ5钾通道调节剂，其可用于治疗神经，神经生理学，神经心理学和神经感染性疾病，病症和障碍，包括但不限于急性和慢性疼痛，偏头痛 ，急性中风，痴呆，血管性痴呆，创伤，癫痫，青光眼性侧索硬化（ALS），多发性硬化症（MS），帕金森病，学习和认知障碍以及神经生理学障碍，包括焦虑症，抑郁症，双相情感障碍，睡眠障碍，成瘾 和饮食失调。

公开(公告)号：US20070031888A1

公开(公告)日：2007-02-08

申请号：US11582264

申请日：2006-10-17

申请人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier

发明人： John Feder ,  Chandra Ramanathan ,  Gabriel Mintier

IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C07K14/705 ,  C12Q1/6883 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/5058 ,  G01N33/5064 ,  G01N33/5076 ,  G01N33/5091 ,  G01N33/68 ,  G01N33/6842

摘要： The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

公开(公告)号：US20070026448A1

公开(公告)日：2007-02-01

申请号：US11515921

申请日：2006-09-05

申请人： Chandra Ramanathan ,  Shuba Gopal ,  John Feder

发明人： Chandra Ramanathan ,  Shuba Gopal ,  John Feder

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28 ,  A61K38/17

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY39多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY39多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。