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    Apparatus and method for inserting an intra-aorta catheter through a delivery sheath
    12.
    发明申请
    Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权

    公开(公告)号：US20060047266A1

    公开(公告)日：2006-03-02

    申请号：US11259187

    申请日：2005-10-25

    申请人： Jeffrey Elkins ,  Harry Goodson ,  Mark Maguire ,  Aurelio Valencia ,  Samir Patel

    发明人： Jeffrey Elkins ,  Harry Goodson ,  Mark Maguire ,  Aurelio Valencia ,  Samir Patel

    IPC分类号： A61M25/01

    CPC分类号： A61M25/0043 ,  A61M25/0662 ,  A61M39/06

    摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

    Systems and methods for tissue mapping and ablation
    14.
    发明授权
    Systems and methods for tissue mapping and ablation 失效
    用于组织测绘和消融的系统和方法

    公开(公告)号：US5916213A

    公开(公告)日：1999-06-29

    申请号：US794804

    申请日：1997-02-04

    申请人： Michel Haissaguerre ,  Walter Bruszewski ,  Le Le ,  Mark Maguire ,  John Gaiser ,  Huu Nguyen

    发明人： Michel Haissaguerre ,  Walter Bruszewski ,  Le Le ,  Mark Maguire ,  John Gaiser ,  Huu Nguyen

    IPC分类号： A61B5/0402 ,  A61B18/08 ,  A61B18/12 ,  A61B18/14 ,  A61M25/00 ,  A61B17/39

    CPC分类号： A61B18/08 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/2945 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/1432 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2218/002

    摘要： A steerable electrophysiology catheter includes a shaft having a distal ablation segment with one or more electrodes coupled to a source of electrical energy by a connector extending through the shaft. The distal ablation segment of the shaft is movable between a collapsed configuration sized for percutaneous introduction into the patient and/or endoluminal delivery to the target site and an expanded configuration, in which the distal ablation segment forms a substantially continuous surface transverse to the shaft axis for engaging the heart tissue and creating a linear lesion thereon. The catheter includes one or more force element(s) positioned to apply an axial force between the distal and proximal ends of the ablation segment. The force element(s) provide a sufficiently uniform force against the distal ablation segment to establish continuous contact pressure between the electrodes and the patient's heart tissue. This contact pressure allows the surgeon to engage the entire length of the distal ablation segment against the heart tissue to provide a relatively long linear lesion on this tissue.

    摘要翻译： 可引导的电生理导管包括具有远端消融段的轴，其具有通过延伸穿过轴的连接器而与电源耦合的一个或多个电极。 轴的远端消融段可在被定形成经皮引入患者体内和/或腔内递送到目标部位的膨胀构型和扩张构型之间移动，其中远侧消融段形成横向于轴线的基本上连续的表面 用于接合心脏组织并在其上产生线性损伤。 导管包括定位成在消融段的远端和近端之间施加轴向力的一个或多个力元件。 力元件提供足够均匀的力抵抗远端消融段，以在电极和患者的心脏组织之间建立连续的接触压力。 该接触压力允许外科医生将远端消融段的整个长度接合心脏组织以在该组织上提供相对较长的线性损伤。

    Intra-aortic renal delivery catheter
    17.
    发明授权
    Intra-aortic renal delivery catheter 失效
    主动脉内肾移植导管

    公开(公告)号：US07563247B2

    公开(公告)日：2009-07-21

    申请号：US10636801

    申请日：2003-08-06

    申请人： Mark Maguire ,  Richard Geoffrion

    发明人： Mark Maguire ,  Richard Geoffrion

    IPC分类号： A61M37/00 ,  A61M31/00 ,  A61M29/00

    CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/0057 ,  A61M2025/0681 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1095 ,  A61M2029/025 ,  A61M2210/127

    摘要： A renal flow system and method direct fluid into renal arteries from a location within the aorta. A renal flow assembly has a tapered tube that is adjustable between a radially collapsed condition for delivery to the location through a delivery sheath and a radially expanded condition that divides aortic flow into exterior and interior paths. The tube's wall is made from a sheet of flexible material, such as PTFE or ePTFE. Two, nickel-titanium rings radially support the tube's ends and are connected by a longitudinal spine support. A fluid delivery assembly injects drug to flow along the exterior flow path and the tubular wall directs the agent into the renal artery ostium. The tube's taper has localized shape for circumferential agent mixing to infuse both kidneys' renals. The flow assembly allows an interventional device, e.g. delivery catheter, to advance across the location while directing blood into the renals and perfusing downstream circulation. The renal flow assembly and distal device are used within a common guide sheath through a single puncture wound. Vasodilators, antioxidants, or diuretics are delivered to the kidneys to treat/prevent RCN, CHF, or ARF.

    摘要翻译： 肾流系统和方法将流体从主动脉内的位置直接导入肾动脉。 肾流组件具有锥形管，该锥形管可在径向折叠状态之间调节，用于通过输送护套输送到位置，以及将主动脉流分成外部和内部路径的径向膨胀状态。 管壁由一层柔性材料制成，如PTFE或ePTFE。 两个镍钛环径向地支撑管的端部并且通过纵向脊柱支撑件连接。 流体输送组件注射药物以沿着外部流动路径流动，并且管状壁将药剂引导到肾动脉口中。 管的锥形具有周向剂混合的局部形状以注入肾脏的肾脏。 流动组件允许介入装置，例如， 输送导管，以引导血液进入肾脏并灌注下游循环。 肾流组件和远端装置通过单个穿刺伤口在通用引导护套内使用。 血管扩张剂，抗氧化剂或利尿剂被输送到肾脏以治疗/预防RCN，CHF或ARF。

    Apparatus and method for inserting an intra-aorta catheter through a delivery sheath
    19.
    发明申请
    Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权
    用于通过输送鞘插入主动脉内导管的装置和方法

    公开(公告)号：US20050245892A1

    公开(公告)日：2005-11-03

    申请号：US11084295

    申请日：2005-03-18

    申请人： Jeffrey Elkins ,  Harry Goodson ,  Mark Maguire ,  Aurelio Valencia ,  Samir Patel

    发明人： Jeffrey Elkins ,  Harry Goodson ,  Mark Maguire ,  Aurelio Valencia ,  Samir Patel

    IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M31/00

    CPC分类号： A61M25/0043 ,  A61M25/0662 ,  A61M39/06

    摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

    摘要翻译： 导引器系统将局部给予患者的肾系统治疗。 近端联接器组件联接到导引器鞘，其将多个装置同时输送到与第一和第二肾动脉口相关联的腹主动脉内的位置。 耦合器组件具有布置成允许多个耦合器件的平滑可滑动接合而没有实质干涉的分支腔的网络。 第一分支腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引器鞘并且基本上与护套的纵向轴线对准。 一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组件与另一装置一起引入导引鞘中。 提供了新的插入装置来协调多个装置的耦合。