公开(公告)号：US20120010414A1

公开(公告)日：2012-01-12

申请号：US13257258

申请日：2010-03-19

申请人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

发明人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

IPC分类号： C07D471/04 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14

CPC分类号： C07D471/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑症（广泛性焦虑障碍，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤和睡眠障碍：

公开(公告)号：US08030499B2

公开(公告)日：2011-10-04

申请号：US11883236

申请日：2006-01-30

申请人： Yoshinori Sekiguchi ,  Takeshi Kuwada ,  Masato Hayashi ,  Dai Nozawa ,  Yuri Amada ,  Tsuyoshi Shibata ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Taketoshi Okubo ,  Takeshi Koami

发明人： Yoshinori Sekiguchi ,  Takeshi Kuwada ,  Masato Hayashi ,  Dai Nozawa ,  Yuri Amada ,  Tsuyoshi Shibata ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Taketoshi Okubo ,  Takeshi Koami

IPC分类号： C07D209/04 ,  A61K31/404

CPC分类号： C07D401/12 ,  C07C309/87 ,  C07D209/38 ,  C07D209/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D417/12

摘要： It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

摘要翻译： 旨在提供对精氨酸 - 加压素V1b受体有关的病理状况有效的药物。 更具体地说，它旨在提供一种对抑郁，焦虑，阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，消化系统疾病，药物成瘾，癫痫，脑梗死，脑缺血具有治疗或预防作用的药物 ，脑水肿，头部损伤，炎症，免疫疾病，脱发等。 作为深入研究的结果，作为精氨酸 - 加压素V1b受体的高度选择性拮抗剂的与杂芳环稠合的新的1,3-二氢-2H-吲哚-2-酮化合物和吡咯烷-2-酮化合物具有 发现高代谢稳定性并显示有利的脑渗透和高血浆浓度，从而实现上述目的。

公开(公告)号：US08193176B2

公开(公告)日：2012-06-05

申请号：US12951978

申请日：2010-11-22

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/5377 ,  A61K31/4155 ,  A61K31/397 ,  A61K31/553 ,  A61K31/496

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

公开(公告)号：US20110065668A1

公开(公告)日：2011-03-17

申请号：US12951978

申请日：2010-11-22

申请人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/695 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/553 ,  A61P25/28 ,  A61P25/18 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P25/00

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US07888354B2

公开(公告)日：2011-02-15

申请号：US12741754

申请日：2008-11-13

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/5377 ,  A61K31/397 ,  A61K31/495 ,  A61K31/4155 ,  C07D413/14 ,  C07D403/14 ,  C07D205/02 ,  C07D231/10

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US08183387B2

公开(公告)日：2012-05-22

申请号：US12951964

申请日：2010-11-22

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： C07D231/10

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US20100267687A1

公开(公告)日：2010-10-21

申请号：US12741754

申请日：2008-11-13

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/4155 ,  C07D403/12 ,  A61P25/28 ,  A61P25/18 ,  A61P25/08 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  C07D413/14 ,  A61K31/5377 ,  C07D231/14 ,  C07D401/14 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/454 ,  A61K31/553 ,  C07D403/14 ,  A61K31/496

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US20080318923A1

公开(公告)日：2008-12-25

申请号：US11883236

申请日：2006-01-30

申请人： Yoshinori Sekiguchi ,  Takeshi Kuwada ,  Masato Hayashi ,  Dai Nozawa ,  Yuri Amada ,  Tsuyoshi Shibata ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Taketoshi Okubo ,  Takeshi Koami

发明人： Yoshinori Sekiguchi ,  Takeshi Kuwada ,  Masato Hayashi ,  Dai Nozawa ,  Yuri Amada ,  Tsuyoshi Shibata ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Taketoshi Okubo ,  Takeshi Koami

IPC分类号： A61K31/397 ,  C07D209/04 ,  C07D401/02 ,  C07D213/02 ,  C07D217/00 ,  C07D413/02 ,  C07D403/14 ,  C07D241/02 ,  C07D471/02 ,  A61P25/00 ,  C07C317/14 ,  A61K31/437 ,  A61K31/501 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/4725 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/404

CPC分类号： C07D401/12 ,  C07C309/87 ,  C07D209/38 ,  C07D209/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D417/12

摘要： It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

摘要翻译： 旨在提供对精氨酸 - 加压素V1b受体有关的病理状况有效的药物。 更具体地说，它旨在提供一种对抑郁，焦虑，阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，消化系统疾病，药物成瘾，癫痫，脑梗死，脑缺血具有治疗或预防作用的药物 ，脑水肿，头部损伤，炎症，免疫疾病，脱发等。 作为深入研究的结果，作为精氨酸 - 加压素V1b受体的高度选择性拮抗剂的与杂芳环稠合的新的1,3-二氢-2H-吲哚-2-酮化合物和吡咯烷-2-酮化合物具有 发现高代谢稳定性并显示有利的脑渗透和高血浆浓度，从而达到上述目的。

公开(公告)号：US09312521B2

公开(公告)日：2016-04-12

申请号：US14241808

申请日：2011-08-29

申请人： Hiroshi Ohta

发明人： Hiroshi Ohta

IPC分类号： H01M2/06 ,  H01M2/30 ,  H01M2/02 ,  H01M2/22 ,  H01M2/24 ,  H01M2/26

CPC分类号： H01M2/06 ,  H01M2/02 ,  H01M2/022 ,  H01M2/024 ,  H01M2/22 ,  H01M2/24 ,  H01M2/26 ,  H01M2/30 ,  H01M2/305

摘要： Disclosed is a cell including: a closed-end tubular case for accommodating a power generation element; a lid for the case; a terminal electrode disposed outside of the case and used for connection with another cell; an extraction electrode passing through the lid and used to extract power of the power generation element to the outside of the case; and a stepped connection electrode disposed outside of the case, the stepped connection electrode having a first flat portion to which the terminal electrode is connected and a second flat portion which is located at a level different from the level of the first flat portion and to which the extraction electrode is connected. The first and second flat portions have regions overlapping each other as viewed in a direction orthogonal to the thickness of the first and second flat portions.

摘要翻译： 公开了一种电池，包括：用于容纳发电元件的封闭端管状壳体; 一箱盖; 端子电极，设置在壳体的外部并用于与另一个电池连接; 通过所述盖并用于将所述发电元件的功率提取到所述壳体的外部的引出电极; 以及设置在所述壳体的外侧的阶梯状连接电极，所述阶梯状连接电极具有与所述端子电极连接的第一平坦部，以及位于与所述第一平坦部的高度不同的水平面的第二平坦部， 引出电极连接。 当与第一和第二平坦部分的厚度正交的方向观察时，第一和第二平坦部分具有彼此重叠的区域。

公开(公告)号：US08716789B2

公开(公告)日：2014-05-06

申请号：US13610532

申请日：2012-09-11

申请人： Syotaro Ono ,  Masaru Izumisawa ,  Hiroshi Ohta ,  Hiroaki Yamashita

发明人： Syotaro Ono ,  Masaru Izumisawa ,  Hiroshi Ohta ,  Hiroaki Yamashita

IPC分类号： H01L29/66

CPC分类号： H01L29/407 ,  H01L29/0634 ,  H01L29/0638 ,  H01L29/0696 ,  H01L29/1095 ,  H01L29/402 ,  H01L29/404 ,  H01L29/66712 ,  H01L29/7395 ,  H01L29/7811 ,  H01L2924/0002 ,  H01L2924/00

摘要： A power semiconductor device according to an embodiment includes an element portion in which MOSFET elements are provided and a termination portion provided around the element portion, and has pillar layers provided respectively in parallel to each other in a semiconductor substrate. The device includes a first trench and a first insulation film. The first trench is provided between end portions of the pillar layers, in the semiconductor substrate at the termination portion exposed from a source electrode of the MOSFET elements. The first insulation film is provided on a side surface and a bottom surface of the first trench.

摘要翻译： 根据实施例的功率半导体器件包括其中设置MOSFET元件的元件部分和设置在元件部分周围的端接部分，并且在半导体衬底中分别彼此平行地设置有柱层。 该装置包括第一沟槽和第一绝缘膜。 第一沟槽设置在从MOSFET元件的源电极露出的终端部分的半导体衬底中的柱层的端部之间。 第一绝缘膜设置在第一沟槽的侧表面和底表面上。