公开(公告)号：US5958782A

公开(公告)日：1999-09-28

申请号：US810969

申请日：1997-02-27

申请人： James G. Bentsen ,  Shih-Hung Chou ,  Elisa M. Cross ,  Kurt J. Halverson ,  John E. Trend ,  Cary A. Kipke ,  Masao Yafuso ,  Sanjay L. Patil

发明人： James G. Bentsen ,  Shih-Hung Chou ,  Elisa M. Cross ,  Kurt J. Halverson ,  John E. Trend ,  Cary A. Kipke ,  Masao Yafuso ,  Sanjay L. Patil

IPC分类号： G01N21/64 ,  C07D498/18 ,  C09B23/10 ,  G01N31/22 ,  G01N33/20 ,  G01N33/487

CPC分类号： C07D498/18 ,  C09B23/102 ,  G01N31/22 ,  G01N31/221

摘要： A fluorescent ionophoric compound is disclosed that includes a complexing moiety, such as a cryptand or crown-ether portion, and a fluorescing moiety such as a coumarin portion. The coumarin portion may be substituted at the 3-position with an electron withdrawing or polarizable group such as a substituted aromatic group or a substituted heterocyclic group having a heteroatom in at least one of its alpha positions. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.

摘要翻译： 公开了一种荧光离子化合物，其包括络合部分，例如穴状或冠醚部分，以及荧光部分如香豆素部分。 香豆素部分可以在3位被吸电子或可极化基团取代，例如取代的芳基或在其α位中的至少一个具有杂原子的取代的杂环基。 具有良好的光稳定性的化合物可以通过方便的共价连接点并入阳离子感应复合结构中。

公开(公告)号：US5583213A

公开(公告)日：1996-12-10

申请号：US439522

申请日：1995-05-12

申请人： Masao Yafuso ,  Robert J. Linhardt

发明人： Masao Yafuso ,  Robert J. Linhardt

IPC分类号： A61L33/00 ,  A61L33/08 ,  C08B37/00 ,  C08B37/02 ,  C08B37/08 ,  C08B37/10

CPC分类号： C08B37/0063 ,  A61L33/0023 ,  A61L33/0094 ,  A61L33/08

摘要： The present specification is directed to a novel process to prepare an activated sulfated polysaccharide which may then be used in subsequent reactions or processes to bind the reactive polysaccharide with a nucleophilic agent or an aminated surface. The activating process comprises the steps of initially forming a polysaccharide tetraalkylammonium salt by contacting an aqueous mixture of a sulfated polysaccharide salt with a cation exchange resin to give a polysaccharide free acid and then contacting the polysaccharide free acid with a tetraalkylammonium hydroxide to give the polysaccharide tetraalkylammonium salt, and subsequently forming an activated sulfated polysaccharide by contacting the polysaccharide tetraalkylammonium salt of step i) with a coupling reagent in an aprotic organic solvent at ambient temperatures for a period of time sufficient to form the activated sulfated polysaccharide.

摘要翻译： 本说明书涉及制备活化的硫酸多糖的新方法，其可以随后用于随后的反应或将活性多糖与亲核试剂或胺化表面结合的方法。 活化方法包括以下步骤：首先通过使硫酸化多糖盐的水性混合物与阳离子交换树脂接触而形成多糖四烷基铵盐，得到多糖游离酸，然后使多糖游离酸与四烷基氢氧化铵接触，得到多糖四烷基铵 盐，随后通过使步骤i）的多糖四烷基铵盐与偶联剂在非质子有机溶剂中在环境温度下接触足以形成活化的硫酸化多糖的时间，形成活化的硫酸化多糖。

公开(公告)号：US5508509A

公开(公告)日：1996-04-16

申请号：US159799

申请日：1993-11-30

申请人： Masao Yafuso ,  Ronnie L. Pratt ,  Kathryn R. Bretscher ,  Kenneth B. Wood ,  John L. Dektar ,  James G. Bentsen

发明人： Masao Yafuso ,  Ronnie L. Pratt ,  Kathryn R. Bretscher ,  Kenneth B. Wood ,  John L. Dektar ,  James G. Bentsen

IPC分类号： G01N31/22 ,  G01N33/49 ,  G01N33/52 ,  G01N33/84 ,  G01N33/50

CPC分类号： G01N33/52 ,  G01N31/223 ,  G01N33/84 ,  Y10T436/207497

摘要： Sensing elements, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g. blood, and methods for making such sensing elements are disclosed. In one embodiment, the method comprises continuously placing a sensing composition precursor in contact with a continuous web, forming a continuous sensing composition from the precursor, and applying a continuous opaque film to the sensing composition. A plurality of individual sensing elements are formed from this composite structure. These sensing elements, which each have very similar sensing characteristics, are placed in a sensor fixture for use.

摘要翻译： 感测元件，可用于感测介质中气体（例如二氧化碳）的浓度，例如二氧化碳。 血液和制造这种感测元件的方法被公开。 在一个实施方案中，该方法包括将感测组合物前体连续地放置成与连续纤维网接触，从前体形成连续感测组合物，以及向感测组合物施加连续的不透明膜。 从该复合结构形成多个单独的感测元件。 这些感测元件（每个具有非常相似的感测特性）被放置在传感器夹具中以供使用。

公开(公告)号：US5296381A

公开(公告)日：1994-03-22

申请号：US742002

申请日：1991-08-08

申请人： Masao Yafuso ,  Paul F. Korkowski ,  Roger A. Mader ,  Cheng Yan ,  John T. Carlock

发明人： Masao Yafuso ,  Paul F. Korkowski ,  Roger A. Mader ,  Cheng Yan ,  John T. Carlock

IPC分类号： A61B5/00 ,  G01N21/62 ,  G01N21/64 ,  G01N21/77

CPC分类号： G01N21/7703 ,  A61B5/1459 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/7786

摘要： A sensing element for sensing the concentration of an analyte in a medium is disclosed. The sensing element comprises a matrix material having at least one indicator component covalently bonded thereto. The indicator component is capable of providing a signal dependent on the concentration of a analyte in a medium. The indicator component is derived from at least one indicator compound having an aromatic ring to which is directly bonded a group including a functional portion which is conjugated relative to this aromatic ring.

摘要翻译： 公开了用于感测介质中分析物浓度的感测元件。 感测元件包括具有至少一个与其共价键合的指示剂组分的基质材料。 指示剂组分能够提供依赖于介质中分析物浓度的信号。 指示剂组分衍生自至少一种具有芳环的指示剂化合物，其直接键合到包含相对于该芳环共轭的官能部分的基团上。

公开(公告)号：US5175016A

公开(公告)日：1992-12-29

申请号：US496560

申请日：1990-03-20

申请人： Masao Yafuso ,  Mark Z. Holody ,  Thomas P. Maxwell ,  Thomas G. Hacker

发明人： Masao Yafuso ,  Mark Z. Holody ,  Thomas P. Maxwell ,  Thomas G. Hacker

IPC分类号： G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N31/22 ,  G01N33/49

CPC分类号： G01N21/783 ,  G01N31/223 ,  Y10T436/204998

摘要： A method for making a sensing element, and an assembled sensing element, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e. g. blood, are disclosed. In one embodiment, the method comprises placing a quantity of a sensing composition precursor between and in contact with a transparent, gas impermeable solid disc and an opaque, gas permeable film, the sensing composition precursor comprises a sensing component, a polymer precursor and a cross-linking agent; and forming a gas sensing composition from this quantity of sensing composition precursor.

公开(公告)号：US5006314A

公开(公告)日：1991-04-09

申请号：US206189

申请日：1988-06-13

申请人： Ted H. Gourley ,  Thomas P. Maxwell ,  Thomas G. Hacker ,  William W. Miller ,  Masao Yafuso

发明人： Ted H. Gourley ,  Thomas P. Maxwell ,  Thomas G. Hacker ,  William W. Miller ,  Masao Yafuso

IPC分类号： A61B5/00 ,  G01N21/64 ,  G01N21/80 ,  G01N21/81 ,  G01N31/22

CPC分类号： G01N21/7703 ,  A61B5/1459 ,  G01N31/223 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/7786 ,  G01N21/80 ,  G01N21/81

摘要： An apparatus for sensing the concentration of a component such as oxygen in a medium such as blood. The apparatus includes an elongated signal transmitter and a sensing element at one end thereof. A substantially rigid sleeve is secured around such end to provide a pocket for the sensing element.

摘要翻译： 用于感测诸如血液的介质中诸如氧的组分的浓度的装置。 该装置包括细长的信号发射器和在其一端的感测元件。 围绕该端部固定有基本刚性的套筒，以提供感测元件的口袋。

公开(公告)号：US20080300554A1

公开(公告)日：2008-12-04

申请号：US12130857

申请日：2008-05-30

申请人： Masao Yafuso

发明人： Masao Yafuso

IPC分类号： A61M25/00 ,  A61K9/00

CPC分类号： A61L29/14 ,  A61L29/085 ,  C08L79/02

摘要： A formulation and method for providing medical devices with a lubricious and non-toxic coating Medical devices having a lubricious, non-toxic coating.

摘要翻译： 为医疗器械提供光滑和无毒涂层的配方和方法具有光滑，无毒涂层的医疗器械。

公开(公告)号：US5498549A

公开(公告)日：1996-03-12

申请号：US373855

申请日：1995-01-18

申请人： Colleen C. Nagel ,  James G. Bentsen ,  Masao Yafuso ,  Alan R. Katritzky ,  John L. Dektar ,  Cary A. Kipke

发明人： Colleen C. Nagel ,  James G. Bentsen ,  Masao Yafuso ,  Alan R. Katritzky ,  John L. Dektar ,  Cary A. Kipke

IPC分类号： A61B5/00 ,  C07F7/08 ,  C08G77/38 ,  G01N21/62 ,  G01N21/64 ,  G01N21/77 ,  G01N31/22

CPC分类号： G01N21/7703 ,  A61B5/1455 ,  A61B5/1459 ,  C07F7/0849 ,  C08G77/38 ,  G01N21/6428 ,  G01N31/225 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/7786 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/255

摘要： A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one or which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.

摘要翻译： 公开了一种用于测量介质中分析物浓度的传感器。 在一个实施例中，传感器包括感测元件，其包括基体材料，并共价键合到一个或多个单体指示器部件，每个单体指示器部件能够响应于暴露于激励信号而提供给定波长的第一发射信号 。 感测元件能够响应于暴露于激励信号而提供具有比第一发射信号更长的波长的第二发射信号，第二发射信号由感测元件中产生的准分子组分由单体 指示剂组分，并且取决于介质中分析物的浓度比第一发射信号或信号更大程度。 在另一个实施例中，传感器包括感测元件，其包括两个或更多个不同的单体成分至少一个或者是能够响应于暴露于第一激发信号而提供第一发射信号的单体指示剂成分。 响应于暴露于第二激励信号，感测元件能够提供第二发射信号。 该第二发射信号由由单体组分产生的激元复合体提供。 该第二发射信号优选地取决于介质中分析物的浓度。 激励组件被定位并适于将激励信号提供给感测元件。 检测器组件被定位并适于检测第二发射信号。 优选地，处理器组件被定位并适于在确定介质中分析物的浓度时分析第二发射信号。

公开(公告)号：US5474743A

公开(公告)日：1995-12-12

申请号：US140257

申请日：1993-10-21

申请人： John E. Trend ,  Cary A. Kipke ,  Mitchell A. Rossman ,  Masao Yafuso ,  Sanjay L. Patil

发明人： John E. Trend ,  Cary A. Kipke ,  Mitchell A. Rossman ,  Masao Yafuso ,  Sanjay L. Patil

IPC分类号： G01N31/22 ,  C07C43/23 ,  C07C45/51 ,  C07C45/60 ,  C07C47/575 ,  C07D498/18 ,  G01N21/64 ,  G01N21/78 ,  G01N33/84 ,  C07D419/02 ,  G01N21/77

CPC分类号： C07D498/18 ,  C07C43/23 ,  C07C45/513 ,  C07C45/60 ,  C07C47/575 ,  G01N33/84

摘要： A fluorescent ionophoric compound comprises a cryptand portion and a coumarin portion substituted at the 3-position with an electron withdrawing or polarizable group. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures useful in biological and environmental testing, which can be used with conventional glass optics, by means of convenient points of covalent attachment.

摘要翻译： 荧光离子化合物包括穴位部分和在3位被吸电子或可极化基团取代的香豆素部分。 具有良好光稳定性的化合物可以并入用于生物和环境测试的阳离子感测复合结构中，其可以通过共价连接的方便点与常规玻璃光学元件一起使用。

公开(公告)号：US5409666A

公开(公告)日：1995-04-25

申请号：US137289

申请日：1993-10-14

申请人： Colleen C. Nagel ,  James G. Bentsen ,  John L. Dektar ,  Cary A. Kipke ,  Masao Yafuso ,  Alan R. Katritzky

发明人： Colleen C. Nagel ,  James G. Bentsen ,  John L. Dektar ,  Cary A. Kipke ,  Masao Yafuso ,  Alan R. Katritzky

IPC分类号： A61B5/00 ,  C07F7/08 ,  C08G77/38 ,  G01N21/62 ,  G01N21/64 ,  G01N21/77 ,  G01N31/22

CPC分类号： G01N21/7703 ,  A61B5/1455 ,  A61B5/1459 ,  C07F7/0849 ,  C08G77/38 ,  G01N21/6428 ,  G01N31/225 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/7786 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/255

摘要： A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one of which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.

摘要翻译： 公开了一种用于测量介质中分析物浓度的传感器。 在一个实施例中，传感器包括感测元件，其包括基体材料，并共价键合到一个或多个单体指示器部件，每个单体指示器部件能够响应于暴露于激励信号而提供给定波长的第一发射信号 。 感测元件能够响应于暴露于激励信号而提供具有比第一发射信号更长的波长的第二发射信号，第二发射信号由感测元件中产生的准分子组分由单体 指示剂组分，并且取决于介质中分析物的浓度比第一发射信号或信号更大程度。 在另一个实施例中，传感器包括感测元件，其包括两个或更多个不同的单体组分，其中至少一个单体组分是能够响应于暴露于第一激发信号而提供第一发射信号的单体指示剂组分。 响应于暴露于第二激励信号，感测元件能够提供第二发射信号。 该第二发射信号由由单体组分产生的激元复合体提供。 该第二发射信号优选地取决于介质中分析物的浓度。 激励组件被定位并适于将激励信号提供给感测元件。 检测器组件被定位并适于检测第二发射信号。 优选地，处理器组件被定位并适于在确定介质中分析物的浓度时分析第二发射信号。