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1.发明授权Sensing elements and methods for uniformly making individual sensing elements 失效用于均匀地制作各个感应元件的感测元件和方法
公开(公告)号：US5508509A
公开(公告)日：1996-04-16
申请号：US159799
申请日：1993-11-30
申请人： Masao Yafuso , Ronnie L. Pratt , Kathryn R. Bretscher , Kenneth B. Wood , John L. Dektar , James G. Bentsen
发明人： Masao Yafuso , Ronnie L. Pratt , Kathryn R. Bretscher , Kenneth B. Wood , John L. Dektar , James G. Bentsen
CPC分类号： G01N33/52 , G01N31/223 , G01N33/84 , Y10T436/207497
摘要： Sensing elements, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g. blood, and methods for making such sensing elements are disclosed. In one embodiment, the method comprises continuously placing a sensing composition precursor in contact with a continuous web, forming a continuous sensing composition from the precursor, and applying a continuous opaque film to the sensing composition. A plurality of individual sensing elements are formed from this composite structure. These sensing elements, which each have very similar sensing characteristics, are placed in a sensor fixture for use.
摘要翻译： 感测元件，可用于感测介质中气体（例如二氧化碳）的浓度，例如二氧化碳。 血液和制造这种感测元件的方法被公开。 在一个实施方案中，该方法包括将感测组合物前体连续地放置成与连续纤维网接触，从前体形成连续感测组合物，以及向感测组合物施加连续的不透明膜。 从该复合结构形成多个单独的感测元件。 这些感测元件（每个具有非常相似的感测特性）被放置在传感器夹具中以供使用。
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公开(公告)号：US5498549A
公开(公告)日：1996-03-12
申请号：US373855
申请日：1995-01-18
申请人： Colleen C. Nagel , James G. Bentsen , Masao Yafuso , Alan R. Katritzky , John L. Dektar , Cary A. Kipke
发明人： Colleen C. Nagel , James G. Bentsen , Masao Yafuso , Alan R. Katritzky , John L. Dektar , Cary A. Kipke
CPC分类号： G01N21/7703 , A61B5/1455 , A61B5/1459 , C07F7/0849 , C08G77/38 , G01N21/6428 , G01N31/225 , G01N2021/6434 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , Y10S436/80 , Y10S436/805 , Y10T436/255
摘要： A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one or which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
摘要翻译： 公开了一种用于测量介质中分析物浓度的传感器。 在一个实施例中，传感器包括感测元件，其包括基体材料，并共价键合到一个或多个单体指示器部件，每个单体指示器部件能够响应于暴露于激励信号而提供给定波长的第一发射信号 。 感测元件能够响应于暴露于激励信号而提供具有比第一发射信号更长的波长的第二发射信号，第二发射信号由感测元件中产生的准分子组分由单体 指示剂组分，并且取决于介质中分析物的浓度比第一发射信号或信号更大程度。 在另一个实施例中，传感器包括感测元件，其包括两个或更多个不同的单体成分至少一个或者是能够响应于暴露于第一激发信号而提供第一发射信号的单体指示剂成分。 响应于暴露于第二激励信号，感测元件能够提供第二发射信号。 该第二发射信号由由单体组分产生的激元复合体提供。 该第二发射信号优选地取决于介质中分析物的浓度。 激励组件被定位并适于将激励信号提供给感测元件。 检测器组件被定位并适于检测第二发射信号。 优选地，处理器组件被定位并适于在确定介质中分析物的浓度时分析第二发射信号。
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公开(公告)号：US5409666A
公开(公告)日：1995-04-25
申请号：US137289
申请日：1993-10-14
申请人： Colleen C. Nagel , James G. Bentsen , John L. Dektar , Cary A. Kipke , Masao Yafuso , Alan R. Katritzky
发明人： Colleen C. Nagel , James G. Bentsen , John L. Dektar , Cary A. Kipke , Masao Yafuso , Alan R. Katritzky
CPC分类号： G01N21/7703 , A61B5/1455 , A61B5/1459 , C07F7/0849 , C08G77/38 , G01N21/6428 , G01N31/225 , G01N2021/6434 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , Y10S436/80 , Y10S436/805 , Y10T436/255
摘要： A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one of which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
摘要翻译： 公开了一种用于测量介质中分析物浓度的传感器。 在一个实施例中，传感器包括感测元件，其包括基体材料，并共价键合到一个或多个单体指示器部件，每个单体指示器部件能够响应于暴露于激励信号而提供给定波长的第一发射信号 。 感测元件能够响应于暴露于激励信号而提供具有比第一发射信号更长的波长的第二发射信号，第二发射信号由感测元件中产生的准分子组分由单体 指示剂组分，并且取决于介质中分析物的浓度比第一发射信号或信号更大程度。 在另一个实施例中，传感器包括感测元件，其包括两个或更多个不同的单体组分，其中至少一个单体组分是能够响应于暴露于第一激发信号而提供第一发射信号的单体指示剂组分。 响应于暴露于第二激励信号，感测元件能够提供第二发射信号。 该第二发射信号由由单体组分产生的激元复合体提供。 该第二发射信号优选地取决于介质中分析物的浓度。 激励组件被定位并适于将激励信号提供给感测元件。 检测器组件被定位并适于检测第二发射信号。 优选地，处理器组件被定位并适于在确定介质中分析物的浓度时分析第二发射信号。
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公开(公告)号：US5958782A
公开(公告)日：1999-09-28
申请号：US810969
申请日：1997-02-27
申请人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
发明人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
IPC分类号： G01N21/64 , C07D498/18 , C09B23/10 , G01N31/22 , G01N33/20 , G01N33/487
CPC分类号： C07D498/18 , C09B23/102 , G01N31/22 , G01N31/221
摘要： A fluorescent ionophoric compound is disclosed that includes a complexing moiety, such as a cryptand or crown-ether portion, and a fluorescing moiety such as a coumarin portion. The coumarin portion may be substituted at the 3-position with an electron withdrawing or polarizable group such as a substituted aromatic group or a substituted heterocyclic group having a heteroatom in at least one of its alpha positions. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.
摘要翻译： 公开了一种荧光离子化合物，其包括络合部分，例如穴状或冠醚部分，以及荧光部分如香豆素部分。 香豆素部分可以在3位被吸电子或可极化基团取代，例如取代的芳基或在其α位中的至少一个具有杂原子的取代的杂环基。 具有良好的光稳定性的化合物可以通过方便的共价连接点并入阳离子感应复合结构中。
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公开(公告)号：US5882936A
公开(公告)日：1999-03-16
申请号：US800435
申请日：1997-02-18
申请人： James G. Bentsen , Kenneth B. Wood
发明人： James G. Bentsen , Kenneth B. Wood
CPC分类号： A61B5/14539 , A61B5/1455 , G01N31/223 , G01N33/84 , G01N2021/7786 , G01N21/7703 , Y10T436/102499 , Y10T436/204998
摘要： The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift.
摘要翻译： 本发明提供一种基于光学荧光的传感器，用于测量诸如血液的介质中的气体（例如，CO 2或氨）的浓度，其具有改善的漂移稳定性。 在优选的实施方案中，本发明的传感器包含具有在疏水屏障相内的pH敏感感测组分的水相的微室。 本发明的传感器基本上没有分配除了目标分析物之外的物质，其可以响应于水相中的pH变化而从一个相迁移到另一个相，并且基本上影响浓度依赖信号。 在替代实施例中，本发明的传感器被构造成延迟分隔物质的迁移，从而降低初始漂移速率。
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公开(公告)号：US5607645A
公开(公告)日：1997-03-04
申请号：US375304
申请日：1995-01-20
申请人： James G. Bentsen , Kenneth B. Wood
发明人： James G. Bentsen , Kenneth B. Wood
IPC分类号： G01N31/00 , A61B5/00 , A61B5/145 , A61B5/1459 , G01N21/77 , G01N31/22 , G01N33/84 , G01N33/50
CPC分类号： A61B5/14539 , A61B5/1455 , G01N31/223 , G01N33/84 , G01N2021/7786 , G01N21/7703 , Y10T436/102499 , Y10T436/204998
摘要： The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift.
摘要翻译： 本发明提供一种基于光学荧光的传感器，用于测量诸如血液的介质中的气体（例如，CO 2或氨）的浓度，其具有改善的漂移稳定性。 在优选的实施方案中，本发明的传感器包含具有在疏水屏障相内的pH敏感感测组分的水相的微室。 本发明的传感器基本上没有分配除了目标分析物之外的物质，其可以响应于水相中的pH变化而从一个相迁移到另一个相，并且基本上影响浓度依赖信号。 在替代实施例中，本发明的传感器被构造成延迟分隔物质的迁移，从而降低初始漂移速率。
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公开(公告)号：US5403746A
公开(公告)日：1995-04-04
申请号：US160687
申请日：1993-11-30
申请人： James G. Bentsen , Kenneth B. Wood
发明人： James G. Bentsen , Kenneth B. Wood
IPC分类号： G01N31/00 , A61B5/00 , A61B5/145 , A61B5/1459 , G01N21/77 , G01N31/22 , G01N33/84 , G01N33/50
CPC分类号： A61B5/14539 , A61B5/1455 , G01N31/223 , G01N33/84 , G01N2021/7786 , G01N21/7703 , Y10T436/102499 , Y10T436/204998
摘要： The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift.
摘要翻译： 本发明提供一种基于光学荧光的传感器，用于测量诸如血液的介质中的气体（例如，CO 2或氨）的浓度，其具有改善的漂移稳定性。 在优选的实施方案中，本发明的传感器包含具有在疏水屏障相内的pH敏感感测组分的水相的微室。 本发明的传感器基本上没有分配除了目标分析物之外的物质，其可以响应于水相中的pH变化而从一个相迁移到另一个相，并且基本上影响浓度依赖信号。 在替代实施例中，本发明的传感器被构造成延迟分隔物质的迁移，从而降低初始漂移速率。
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公开(公告)号：US07442421B2
公开(公告)日：2008-10-28
申请号：US11757723
申请日：2007-06-04
申请人： Yingbo Li , John P. Baetzold , Terence D. Spawn , Ralph R. Roberts , James G. Bentsen , John S. Staral
发明人： Yingbo Li , John P. Baetzold , Terence D. Spawn , Ralph R. Roberts , James G. Bentsen , John S. Staral
CPC分类号： H01L51/0039 , C08G61/02 , C08G61/10 , C09K11/06 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1051 , C09K2211/1416 , C09K2211/1483 , H01L51/0035 , H01L51/0036 , H01L51/0037 , H01L51/0043 , H01L51/50 , Y10S428/917
摘要： Light emitting polymers can include a plurality of arylene monomeric units and a plurality of soft segment units independently selected from soft segment end caps; soft segment side chains coupled to a portion, but not all, of the arylene monomeric units; internal soft segment monomeric units; and combinations thereof. These light emitting polymers can be used in forming electroluminescent devices or other articles.
摘要翻译： 发光聚合物可以包括多个亚芳基单体单元和多个软段单元，其独立地选自软段端盖; 耦合到一部分但不是全部的亚芳基单体单元的软链段侧链; 内部软段单体单元; 及其组合。 这些发光聚合物可用于形成电致发光器件或其它制品。
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公开(公告)号：US07060419B2
公开(公告)日：2006-06-13
申请号：US10297962
申请日：2001-06-14
CPC分类号： B29C35/08 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01L3/502707 , B01L2200/12 , B01L2300/0887 , G03F7/031 , G03F7/038 , G03F7/2053
摘要： A process for producing microfluidic articles comprises (a) preparing a photoreactive composition comprising (1) at least one reactive species that is a polymer or a polymer precursor and that is capable of undergoing an acid- or radical-initiated chemical reaction and (2) at least one multiphoton photoinitiator system; (b) exposing a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby forming exposed and unexposed portions of the composition, and thereby inducing at least one acid- or radical-initiated chemical reaction in the exposed portion; and (c) removing either the exposed or the unexposed portion of the composition, so as to form a microfluidic article comprising a seamless polymer matrix that defines at least one inlet, at least one outlet, and a microfluid processing architecture that is capable of fluidic communication with the inlet and the outlet and that is otherwise fully enclosed within the polymer matrix.
摘要翻译： 制备微流体制品的方法包括（a）制备光反应性组合物，其包含（1）至少一种作为聚合物或聚合物前体的反应性物质，并且能够经历酸或自由基引发的化学反应，和（2） 至少一种多光子光引发剂体系; （b）将组合物的一部分暴露于足以引起同时吸收至少两个光子的光，从而形成组合物的暴露部分和未曝光部分，从而在暴露部分中诱导至少一种酸或自由基引发的化学反应 ; 和（c）去除组合物的暴露部分或未曝光部分，以形成包含无定形聚合物基质的微流体制品，所述无缝聚合物基质限定至少一个入口，至少一个出口以及能够流动的微流体加工结构 与入口和出口的通信，否则完全封闭在聚合物基质内。
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公开(公告)号：US07014978B2
公开(公告)日：2006-03-21
申请号：US10732853
申请日：2003-12-10
申请人： Erika Bellmann , James G. Bentsen , Yong Hsu , Manoj Nirmal , Martin B. Wolk
发明人： Erika Bellmann , James G. Bentsen , Yong Hsu , Manoj Nirmal , Martin B. Wolk
IPC分类号： H01J9/227
CPC分类号： H01L51/0059 , C09K11/06 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/1048 , C09K2211/1055 , C09K2211/1059 , H01L51/0003 , H01L51/0004 , H01L51/0013 , H01L51/0014 , H01L51/0015 , H01L51/0024 , H01L51/0037 , H01L51/0038 , H01L51/0053 , H01L51/0062 , H01L51/0067 , H01L51/007 , H01L51/0072 , H01L51/0081 , H01L51/0094 , H01L51/0095 , H01L51/5012 , H01L51/5016 , H01L51/56 , H01L2251/308 , H05B33/14 , Y10S428/917 , Y10S430/165
摘要： In one method of making an organic electroluminescent device, a transfer layer is solution coated on a donor substrate. The transfer layer includes an amorphous, non-polymeric, organic matrix with a light emitting material disposed in the matrix. The transfer layer is then selectively patterned on a receptor. Examples of patterning methods include laser thermal transfer or thermal head transfer. The method and associated materials can be used to form, for example, organic electroluminescent devices.
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