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公开(公告)号：US10414774B2
公开(公告)日：2019-09-17
申请号：US16324596
申请日：2017-08-10
Applicant: Merck Sharp & Dohme Corp. , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
Inventor： Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC: C07D487/04 , C07D519/00 , A61P3/10 , C07D498/04 , C07D513/04 , C07D471/04
Abstract: Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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12.发明申请公开(公告)号：US20190218224A1
公开(公告)日：2019-07-18
申请号：US16324604
申请日：2017-08-10
Applicant: Merck Sharp & Dohme Corp.
Inventor： John P. Caldwell , Mary Ann Caplen , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Claire Lankin , Derun Li , Hong Liu , Amy McCracken , Brian McKittrick , Ashwin Rao , Jayaram Tagat , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu , Tianyuan Zhang
IPC: C07D487/04 , C07D519/00 , C07D498/04
CPC classification number: C07D487/04 , C07D498/04 , C07D519/00
Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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公开(公告)号：US20220259188A1
公开(公告)日：2022-08-18
申请号：US17614732
申请日：2020-06-01
Applicant: Hua ZHOU , John J. ACTON, III , Michael J. ARDOLINO , Yi-Heng CHEN , Peter H. FULLER , Anmol GULATI , Rebecca Elizabeth JOHNSON , William P. KAPLAN , Solomon D. KATTAR , Mitchell H. KEYLOR , Derun LI , Kaitlyn Marie LOGAN , Min LU , Gregori J. MORRIELLO , Santhosh F. NEELAMKAVIL , Barbara PIO , Nunzio SCIAMMETTA , Vladimir SIMOV , Jing SU , Luis TORRES , Xin YAN , Merck Sharp & Dohme Corp.
Inventor： Hua Zhou , John J. Acton, III , Michael J. Ardolino , Yi-Heng Chen , Peter H. Fuller , Anmol Gulati , Rebecca Elizabeth Johnson , William P. Kaplan , Solomon D. Kattar , Mitchell H. Keylor , Derun Li , Kaitlyn Marie Logan , Min Lu , Gregori J. Morriello , Santhosh F. Neelamkavil , Barbara Pio , Nunzio Sciammetta , Vladimir Simov , Jing Su , Luis Torres , Xin Yan
IPC: C07D405/14 , C07D487/08 , C07D409/14 , C07D403/04 , C07D403/14 , C07D498/04 , C07D498/08 , C07D487/10 , C07D401/14 , C07D471/10 , C07D491/107 , C07D471/04 , C07D487/04 , A61P25/16
Abstract: The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.
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公开(公告)号：US11274111B2
公开(公告)日：2022-03-15
申请号：US16973623
申请日：2019-06-14
Applicant: Merck Sharp & Dohme Corp.
Inventor： Abdelghani Abe Achab , Jared N. Cumming , Christian Fischer , Symon Gathiaka , Charles A. Lesburg , Derun Li , Min Lu , Matthew J. Mitcheltree , Anandan Palani , Rachel L. Palte , David L. Sloman , Hongjun Zhang
Abstract: Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.
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公开(公告)号：US10995085B2
公开(公告)日：2021-05-04
申请号：US16819325
申请日：2020-03-16
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC: C07D405/10 , A61K31/4523 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4427 , C07D263/32 , A61P37/00 , C07D231/12 , A61P35/00 , C07D413/10 , C07D401/12 , C07D405/04 , A61P31/00 , C07D209/46 , C07D413/14
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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Patent Agency Ranking
16.发明申请公开(公告)号：US20200231606A1
公开(公告)日：2020-07-23
申请号：US16326408
申请日：2017-08-24
Applicant: Merck Sharp & Dohme Corp.
Inventor： Kun Liu , Abdelghani Achab , Purakkattle Biju , Timothy A. Cernak , Yongqi Deng , Xavier Fradera , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Derun Li , Guoqing Li , Qinglin Pu , Zhi-Cai Shi , Wensheng Yu , Hongjun Zhang
IPC: C07F5/02 , C07D271/08 , C07D413/12
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US10647705B2
公开(公告)日：2020-05-12
申请号：US16186769
申请日：2018-11-12
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC: C07D405/10 , A61K31/4523 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4427 , C07D263/32 , A61P37/00 , C07D231/12 , A61P35/00 , C07D413/10 , C07D401/12 , C07D405/04 , A61P31/00 , C07D209/46 , C07D413/14
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US09695198B2
公开(公告)日：2017-07-04
申请号：US14652150
申请日：2013-12-16
Applicant: Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
Inventor： Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC: C07D413/14 , C07D417/06 , C07D498/04 , C07D513/04 , C07D413/12 , C07D471/04 , C07D413/06
CPC classification number: C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
Abstract: The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
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公开(公告)号：US20220281886A1
公开(公告)日：2022-09-08
申请号：US17611553
申请日：2020-05-18
Applicant: Merck Sharp & Dohme Corp.
Inventor： Frank Bennett , Jason E. Imbriglio , Angela D. Kerekes , Tanweer Khan , Claire Lankin , Derun Li , Zhicai Wu , Yusheng Xiong , Hyewon Youm , Yang Yu , Feng Ye , Anthappan Tony Kurissery , Venukrishnan Komanduri
IPC: C07D491/107 , A61K45/06 , C07D401/14 , C07D413/14
Abstract: The present invention relates to Compounds of Formula I: I and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of cardiometabolic diseases including high blood pressure, heart failure, kidney disease, and diabetes in a subject.
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公开(公告)号：US20210403469A1
公开(公告)日：2021-12-30
申请号：US17289062
申请日：2019-11-01
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , David Jonathan Bennett , Indu Bharathan , Liangqin Guo , Brett A. Hopkins , Xianhai Huang , Derun Li , Min Lu , Alexander Pasternak , David L. Sloman , Hongjun Zhang , Hua Zhou
IPC: C07D471/04 , C07D401/04 , C07D215/14 , C07D209/94 , C07D403/04
Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Formula (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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