公开(公告)号：US20100268041A1

公开(公告)日：2010-10-21

申请号：US12757307

申请日：2010-04-09

申请人： Thomas KRAEMER ,  Michael Lippert ,  Olaf Skerl ,  Gerald Czygan ,  Stefan Paule

发明人： Thomas KRAEMER ,  Michael Lippert ,  Olaf Skerl ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/00

CPC分类号： A61B5/0537 ,  A61B5/0031 ,  A61B5/1116 ,  A61B5/4869 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/686 ,  A61B2562/0219 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3655 ,  A61N1/36564 ,  A61N1/36571

摘要： A monitoring apparatus having a signal input for signals representing measurement values of one or more physiological parameters, and an evaluation and processing unit connected to the signal input. The evaluation and processing unit is designed to select, or differently weight, individual values from the values received for further processing based on one or more criteria such that measurement values raising doubts as to the validity thereof are not selected or given a very low weighting.

摘要翻译： 一种具有用于表示一个或多个生理参数的测量值的信号的信号输入的监视装置，以及连接到所述信号输入的评估和处理单元。 评估和处理单元被设计为基于一个或多个标准从接收到的值中选择或不同地对各个值进行选择，以使得对其有效性产生怀疑的测量值不被选择或给出非常低的权重。

公开(公告)号：US20080249585A1

公开(公告)日：2008-10-09

申请号：US12061796

申请日：2008-04-03

申请人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

发明人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/37 ,  A61N1/37241 ,  A61N2001/0585

摘要： A device is connected to electrode leads which performs intracardiac impedance measurements, conducts a transient pacing protocol, analyses the impedance measurements, and generates an LV lead position quality factor. The transient pacing protocol includes a repeated change (“transitions”) between ventricular intrinsic rhythm and biventricular paced rhythm and may also include a variation of the atrioventricular delay (AVD) and/or the interventricular delay (VVD). The quality factor expresses the degree to which hemodynamic properties have improved due to BiV stimulation for the current LV lead position compared to intrinsic ventricular rhythm.

摘要翻译： 器件连接到执行心内阻抗测量的电极引线，执行瞬态起搏协议，分析阻抗测量值，并产生LV引线位置品质因数。 瞬时起搏方案包括心室内心节律与双心室起搏节律之间的重复变化（“转变”），还可包括房室延迟（AVD）和/或心室间延迟（VVD）的变化。 质量因子表现出与本征心室节律相比，由于针对当前LV引导位置的BiV刺激，血液动力学特性得到改善的程度。

公开(公告)号：US20080195162A1

公开(公告)日：2008-08-14

申请号：US11970662

申请日：2008-01-08

申请人： Michael Lippert ,  Olaf Skerl ,  Stefan Paule ,  Bernhard Fahn ,  Gerald Czygan ,  Heinrich Reinke ,  Albrecht Urbaszek

发明人： Michael Lippert ,  Olaf Skerl ,  Stefan Paule ,  Bernhard Fahn ,  Gerald Czygan ,  Heinrich Reinke ,  Albrecht Urbaszek

IPC分类号： A61B5/053 ,  A61N1/362

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/14535 ,  A61B5/7207

摘要： An implantable medical device has an impedance or admittance determination unit, an alternating current or voltage source, a measuring unit, and an analysis unit which is connected to the alternating current or AC voltage source and the measuring unit to calculate an impedance value or an admittance value at different times. The impedance or admittance determination unit may generate measuring current having two different frequencies (preferably below 100 kHz), and the analysis unit may calculate pairs of impedance or admittance values which are chronologically assigned to one another for different frequencies of the measuring current, and calculate a value for a blood impedance or blood admittance component which is independent of the impedance of the body tissue surrounding a particular blood vessel, The analysis unit may also determine trends in this value over time as an indicator for a change of blood hematocrit value.

摘要翻译： 可植入医疗装置具有阻抗或导纳确定单元，交流或电压源，测量单元和分析单元，其连接到交流电压源或交流电压源和测量单元以计算阻抗值或导纳 价值在不同的时间。 阻抗或导纳确定单元可以产生具有两个不同频率（优选低于100kHz）的测量电流，并且分析单元可以计算针对测量电流的不同频率按时间顺序分配给彼此的阻抗或导纳值对，并且计算 血液阻抗或血液导入分量的值，其独立于围绕特定血管的身体组织的阻抗。分析单元还可以确定该值随时间的趋势作为血液血细胞比容值变化的指标。

公开(公告)号：US20070055170A1

公开(公告)日：2007-03-08

申请号：US11517155

申请日：2006-09-07

申请人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

发明人： Michael Lippert ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/05

CPC分类号： A61B5/0535 ,  A61B5/7239 ,  A61N1/36521

摘要： A device for detecting the state of a heart on the basis of intracardial impedance measurement. The device has an impedance measuring unit, which has electrical terminals, configured to be electrically connected or to be connected to electrodes for delivering and detecting a current or voltage, and is implemented to ascertain an impedance on the basis of the dimension of the delivered current or voltage and the voltage drop caused by the current or the current caused by the voltage, as well as an analysis unit, which is connected to the impedance measuring unit and is implemented to derive a cardiac function parameter from a time curve of the impedance ascertained using the impedance measuring unit. The analysis unit analyzes the impedance curve assigned to a diastole and derives a cardiac function parameter characterizing the behavior of a heart during the diastole (filling phase of the ventricle).

摘要翻译： 一种用于基于心内阻抗测量来检测心脏状态的装置。 该装置具有阻抗测量单元，其具有电端子，其被配置为电连接或连接到用于传送和检测电流或电压的电极，并且被实现为基于所传送的电流的尺寸来确定阻抗 或电压以及由电压引起的电流或电流导致的电压降以及分析单元，该分析单元连接到阻抗测量单元，并被实现为从所确定的阻抗的时间曲线导出心脏功能参数 使用阻抗测量单元。 分析单元分析舒张期的阻抗曲线，得出表征心脏舒张期（心室充盈期）心脏功能的参数。

公开(公告)号：US20090216145A1

公开(公告)日：2009-08-27

申请号：US12389719

申请日：2009-02-20

申请人： Olaf SKERL ,  Micahel Lippert ,  Gerald Czygan ,  Stefan Paule

发明人： Olaf SKERL ,  Micahel Lippert ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61B5/08 ,  A61N1/362

CPC分类号： A61B5/0809 ,  A61B5/0535 ,  A61N1/36521 ,  A61N1/37258

摘要： A system which generates a warning signal in the event of looming pulmonary edema and/or looming decompensation. The system has an impedance detection unit for determining impedance values, which represent a transthoracic impedance course, and an impedance analysis unit (78), which is connected to the impedance detection unit. The impedance analysis unit (78) is implemented to determine the degree of modulation for a particular impedance course detected by the impedance detection unit.

摘要翻译： 在发生肺水肿和/或逼近失代偿的情况下产生警告信号的系统。 系统具有阻抗检测单元，用于确定表示经胸阻抗路线的阻抗值，以及阻抗分析单元（78），其连接到阻抗检测单元。 阻抗分析单元（78）被实现以确定由阻抗检测单元检测到的特定阻抗进程的调制度。

公开(公告)号：US20100010354A1

公开(公告)日：2010-01-14

申请号：US12497778

申请日：2009-07-06

申请人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

发明人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

IPC分类号： A61B8/14

CPC分类号： A61B5/1107 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/107 ,  A61B5/6846 ,  A61B5/686 ,  A61B8/02 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/42 ,  A61B8/4483 ,  A61B8/543 ,  A61N1/36578

摘要： An implantable measurement arrangement for intracorporeal acoustic measurement of geometric parameters and motion parameters in and on organs and/or tissues of a patient includes an implantable device, in particular an electromedical device; an implantable sonic transducer for transmitting and receiving ultrasonic waves, the transducer being in signal connection with the implantable device; and an implantable reflector in communication with the implantable device and situated at a distance from the sonic transducer for reflecting the ultrasonic waves back in the direction of the sonic transducer. The electromedical device can analyze the ultrasonic waves picked up and reflected back by the sonic transducer.

摘要翻译： 用于体内和/或组织中几何参数和运动参数的体内声学测量的可植入测量装置包括可植入装置，特别是电动医疗装置; 用于发射和接收超声波的可植入声波换能器，所述换能器与所述可植入装置信号连接; 以及可植入反射器，其与所述可植入装置连通并且位于距离所述声音换能器一定距离处，用于将所述超声波反射回所述声音换能器的方向。 电子设备可以分析由声音传感器拾取并反射回的超声波。

公开(公告)号：US08965493B2

公开(公告)日：2015-02-24

申请号：US13040926

申请日：2011-03-04

申请人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

发明人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

IPC分类号： A61B5/04 ,  A61B5/053 ,  A61B5/00

CPC分类号： A61B5/0535 ,  A61B5/6846 ,  A61B5/7207 ,  A61B2562/0209 ,  A61B2562/043

摘要： An electromedical implant for monitoring a thoracic property of a living being is provided that includes a detector arrangement including an impedance measuring unit and an electrode arrangement, which are equipped to capture a measurement signal associated with the thoracic property in the form of an impedance signal; a monitoring arrangement, which is connected to the detector arrangement and equipped to generate a parameter from the measurement signal that is indicative of the thoracic property, and an evaluation unit, which is connected to the monitoring arrangement and equipped to determine an evaluation result regarding the thoracic property based on the parameter. According to the invention, the electrode arrangement comprises at least a plurality of mutually isolated electrodes, which are disposed on the housing and operatively connected by way of the impedance measuring unit and which can be separately controlled, wherein an electrode body has a strip shape.

摘要翻译： 提供了一种用于监测生命体的胸部性质的电植入物，其包括检测器装置，所述检测器装置包括阻抗测量单元和电极装置，其被配备为以阻抗信号的形式捕获与胸部特性相关联的测量信号; 监视装置，其连接到所述检测器装置，并且被配备为从所述测量信号生成指示胸部特性的参数;以及评估单元，所述评估单元连接到所述监视装置并被配备以确定关于所述检测装置的评估结果 胸部属性基于参数。 根据本发明，电极布置包括至少多个相互隔离的电极，它们设置在壳体上并且通过阻抗测量单元可操作地连接并且可以被单独控制，其中电极体具有带状。

公开(公告)号：US08491485B2

公开(公告)日：2013-07-23

申请号：US13038428

申请日：2011-03-02

申请人： Gerald Czygan ,  Michael Lippert ,  Olaf Skerl

发明人： Gerald Czygan ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61B5/024 ,  A61B5/026

CPC分类号： A61B5/0535 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0402 ,  A61B5/6846 ,  A61B5/721 ,  A61B5/7214 ,  A61B5/7275

摘要： An electromedical implant (100, 101, 102, 103) for monitoring a cardiac blood flow (B1) of a patient includes a detector (10, 10′, 10″) which obtains a first measurement signal (S1) associated with the cardiac blood flow (B1) and a second measurement signal (S2) associated with the epithoracic, peripheral blood flow (B2). A monitoring assembly (20) then generates a first parameter (P1) from the first measurement signal (S1) which is indicative of a time (tsys) at which blood is ejected from the heart, and a second parameter (2) from the second measurement signal (S2) which is indicative of a time (tgef) of a blood pulse in the thoracic tissue which is associated with the ejection of blood. An evaluation unit (30) then generates a pulse transit time (Δt=tgef−tsys) from the first parameter (P1) and the second parameter (P2). The detector (10, 10′, 10″) includes an impedance measuring unit (12) having an electrode assembly (11, 11′) for detection of at least the second measurement signal (S2) in the form of an impedance signal.

摘要翻译： 用于监测患者的心脏血流（B1）的电植入物（100,101,102,103）包括检测器（10,10'，10“），其获得与心脏相关联的第一测量信号（S1） 血液流（B1）和与脑外周血流（B2）相关联的第二测量信号（S2）。 监测组件（20）然后从第一测量信号（S1）产生指示从心脏喷出血液的时间（tsys）的第一参数（P1），以及来自第二测量信号的第二参数（2） 测量信号（S2），其指示与血液喷射相关联的胸部组织中的血液脉冲的时间（tgef）。 评估单元（30）然后从第一参数（P1）和第二参数（P2）产生脉冲传播时间（Deltat = tgef-tsys）。 检测器（10,10'，10“）包括具有用于以阻抗信号的形式检测至少第二测量信号（S2）的电极组件（11,11'）的阻抗测量单元（12）。

公开(公告)号：US07702389B2

公开(公告)日：2010-04-20

申请号：US11559626

申请日：2006-11-14

申请人： Gerald Czygan ,  Michael Lippert

发明人： Gerald Czygan ,  Michael Lippert

IPC分类号： A61N1/00

CPC分类号： A61N1/3627

摘要： The invention concerns implantable cardiac stimulation devices in general which have at least one stimulation pulse generator (A-STIM; RV-STIM; LV-STIM) to selectively generate a stimulation pulse for delivery to one of at least two different chambers of a heart, said chambers include right and left atria and right and left ventricles, at least one impedance measuring stage (I, U, IMP) being connected to electrodes or connectors for such electrodes to measure an intracardiac impedance when in use, a control unit (CTRL) connected to the stimulation pulse generator and to the impedance measuring unit and being adapted to process a minimum impedance value for a heart cycle to trigger stimulation pulses for two different chambers of the heart with an adjustable time delay (VVD; AVD) and to adjust said time delay depending upon the measured intracardiac impedance minimum value. According to the invention the control unit is adapted to adjust the time delay such that the minimum value of the intracardiac impedance during one heart cycle is minimized or such that the AVD delay is equal to the time interval between an atrial event and the point of time when the minimum impedance value occurs after said atrial contraction.

摘要翻译： 本发明涉及一般具有至少一个刺激脉冲发生器（A-STIM; RV-STIM; LV-STIM）的可植入心脏刺激装置，以选择性地产生用于递送至心脏的至少两个不同室中的一个的刺激脉冲， 所述腔室包括右心房和左心房以及右心室和左心室，至少一个阻抗测量平台（I，U，IMP）连接到用于这种电极的电极或连接器，用于在使用时测量心内阻抗，控制单元（CTRL） 连接到刺激脉冲发生器和阻抗测量单元，并且适于处理用于心脏周期的最小阻抗值以用可调节的时间延迟（VVD; AVD）触发心脏的两个不同腔室的刺激脉冲，并且调整所述 时间延迟取决于测量的心内阻抗最小值。 根据本发明，控制单元适于调整时间延迟，使得在一个心脏周期期间心内阻抗的最小值被最小化或使得AVD延迟等于心房事件与时间点之间的时间间隔 当在所述心房收缩之后发生最小阻抗值时。

公开(公告)号：US20090048524A1

公开(公告)日：2009-02-19

申请号：US12190113

申请日：2008-08-12

申请人： Hans-Jurgen WILDAU ,  Gerald Czygan ,  Michael Diebold ,  Michael Lippert ,  Claus Harder ,  Thomas Schmitz-Rode

发明人： Hans-Jurgen WILDAU ,  Gerald Czygan ,  Michael Diebold ,  Michael Lippert ,  Claus Harder ,  Thomas Schmitz-Rode

IPC分类号： A61B5/0215

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/02156 ,  A61B5/02158 ,  A61B5/6862 ,  A61B5/6876 ,  A61B5/6882 ,  A61B2560/0219 ,  A61B2560/0252 ,  A61B2560/0257

摘要： Implantable pressure measuring unit for internal pressure measurement in a blood vessel or heart of a patient, having a pressure sensor having electrical signal output, fixing means adapted to the intended measurement location for fixing the pressure sensor, a power supply unit of the pressure sensor, a signal detection unit connected by a line to the signal output of the pressure sensor, and a transmitting unit connected to a measurement data output of the signal detection unit, in particular for wireless transmission of measurement data to an analysis unit, in particular outward from the patient body.

摘要翻译： 一种用于在患者的血管或心脏中进行内部压力测量的可植入压力测量单元，具有具有电信号输出的压力传感器，适于用于固定压力传感器的预期测量位置的固定装置，压力传感器的电源单元， 信号检测单元，其通过线路连接到压力传感器的信号输出;以及发送单元，连接到信号检测单元的测量数据输出，特别是用于将测量数据无线传输到分析单元，特别是从 病人身体。