摘要:
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要:
The invention provides a dryer for drying particulate material, comprising at least one substantially vertical elongate container having: an upper inlet for receiving a charge of moisture containing particulate material; a lower outlet for discharging dried particulate material, whereby the particulate material travels under the influence of gravity from the inlet to the outlet; at least one substantially vertical gas permeable wall through which a drying gas can pass to contact the particulate material; the dryer also comprising at least one plenum on an exterior surface of the at least one gas permeable wall, covering ingress and egress openings within the at least one gas permeable wall.
摘要:
A wideband tuneable low noise amplifier that is capable of receiving signals over a wide range of frequencies, providing tuneable filtering to remove out of band interferer signals, and providing variable gain for a wide range of frequencies. To accommodate variable gain, the low noise amplifier has an amplifier stage comprising two gain stages, and the relationship between the gain stages is controlled responsive to changes in the voltage gain of an input stage. Linearity monitoring combined with Q-enhance may be employed to increase performance at low signal levels.
摘要:
A surface mount antenna includes a ground plane, a feed line, and a radiating element. The ground plane extends in a first direction on a first side of a substrate. The feed line extends in a second direction on a second side of the substrate. The radiating element includes a plurality of segments disposed on the first side of the substrate and is configured to resonate in a plurality of frequency modes.
摘要:
One embodiment of the present invention provides a system that provides access to an application-resource. During operation, the system receives a request to access an application-resource associated with an application, wherein the request is received at an application-server that hosts the application. The system then determines an authentication-level required to access the application-resource. Next, the system sends the required authentication-level to an authentication-server. In response, the system receives an authentication-response from the authentication-server. Next, the system determines if the authentication-response specifies that the user is authenticated to access the application-resource. If so, the system grants the user access to the application-resource.One embodiment of the present invention provides a system that provides an authentication-token associated with a lower authentication-level in response to an authentication-token associated with a higher authentication-level expiring. Note that the lower authentication-level meets or exceeds a required authentication-level and does not require a user to re-authenticate.
摘要:
A powered driver and methods are disclosed, the driver including a head having a gapped jaw and housing a motor driven drive transfer assembly for operating a rotatable split socket engageable at a threaded connector. A reaction unit having a biased fitting engagement attached to rail guides is movably maintained through the head, and a probe and switch are associated with different ones of the reaction unit and the head. A safety assembly includes a biased gate switch engageable with a signal switch and is located at the head for sending run status electrical signals to the driver dependent on position of the gate switch. Indicator and control arrays are provided for user interface and driver status monitoring.
摘要:
Disclosed are methods of transferring heat to or from a fluid or body comprising causing heat to be transferred to or from a composition comprising at least trans-1,3,3,3-tetrafluorpropene.
摘要:
Engineered binding proteins are provided. In some cases, the parent protein corresponding to the engineered protein has a three-layer swiveling β/β/α domain. In other cases, the parent protein corresponding to the engineered protein has a rubredoxin-like fold. At least one portion of the primary sequence of the engineered protein is determined by an engineering scheme. In some case, the engineered protein is characterized by an ability to bind to a compound that the parent protein does not bind. In some cases, the parent protein is derived from a domain of a chaperonin or a rubredoxin. One form of engineering scheme used is a randomization scheme. A method for making libraries of engineered proteins, all based on a single parent protein is provided. Methods to identify proteins that bind to compounds of interest in libraries of engineered libraries are provided. An array of engineered proteins immobilized on a support is provided. Each engineered protein in the array is a chaperonin domain or a rubredoxin that has been subjected to an engineering scheme.
摘要:
The invention provides a dryer for drying particulate material, comprising at least one substantially vertical elongate container having an upper inlet (56a, 56b) for receiving a charge of moisture containing particulate material; a lower outlet (22) for discharging dried particulate material, whereby said particulate material travels under the influence of gravity from said inlet to said outlet; at least one substantially vertical gas permeable wall (20a, 20b) through which a drying gas can pass to contact said particulate material; said dryer also comprising at least one plenum (48, 50) on an exterior surface of said at least one gas permeable wall, covering ingress (38a) and egress openings within said at least one gas permeable wall.
摘要:
A cosmetic applicator includes a handle, a drive coupled to the handle, an applicator head coupled to the drive, and a torque limiter coupled to or within at least one of the drive and the applicator head such that the torque applied via the applicator head does not exceed a predetermined allowable torque.