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公开(公告)号：US20100185270A1
公开(公告)日：2010-07-22
申请号：US12649044
申请日：2009-12-29
CPC分类号： A61L2/20 , A61F2/958 , A61L2/08 , A61L2/087 , A61L2/206 , A61L2/208 , A61L2202/10 , A61L2202/24 , A61M25/0097 , A61M25/10 , A61M2025/0019
摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.
摘要翻译： 描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。 单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。 另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。
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公开(公告)号：US5059205A
公开(公告)日：1991-10-22
申请号：US404166
申请日：1989-09-07
申请人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
发明人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
CPC分类号： A61F2/01 , A61F2002/016 , A61F2002/8486 , A61F2230/005 , A61F2230/0067
摘要： A filter device positionable within a blood vessel for trapping blood clots in that vessel, the filter device comprising a head with a plurality of divergent legs each secured at its proximal end, to the head, each leg having a hook arranged at its distal end. The distal end includes a reversely bent portion of the leg which itself is bent radially outwardly, ending in the shape of a sharp point. The reversely bent portion of the leg comprises a pad to minimize the depth of penetration of the hook.A further embodiment of the leg shows a radially outwardly directed radius of curvature to create a conical configuration to the filter assembly, while distributing the stress concentration along the length of the bend, so that the elastic limit of the material, stainless steel in this embodiment, is not exceeded, and which permits compact delivery of the filter, and adequate radially directed force to permit slight hook penetration of a vessel wall.
摘要翻译： 一种位于血管内的过滤器装置，用于捕获血管内的血块，该过滤装置包括头部，该头部具有多个分支腿，每个头部在其近端固定到头部，每个腿部具有设置在其远端的钩。 远端包括腿的反向弯曲部分，其本身被径向向外弯曲，以尖锐的形状终止。 腿的反向弯曲部分包括垫，以最小化钩的穿透深度。 腿的另一实施例示出了径向向外指向的曲率半径，以在沿着弯曲部分的长度分布应力集中的同时向过滤器组件产生锥形结构，使得在该实施例中的不锈钢材料的弹性极限 ，并且其允许过滤器的紧密输送以及足够的径向力以允许容器壁的轻微的钩子穿透。
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13.发明授权Catheter having window and partial balloon covering for dissecting tissue planes and injecting treatment agent to coronary blood vessel 有权导管具有用于解剖组织平面和将治疗剂注射到冠状动脉血管的窗口和部分气囊覆盖物公开(公告)号：US09504491B2
公开(公告)日：2016-11-29
申请号：US11936668
申请日：2007-11-07
申请人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
发明人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
IPC分类号： A61B17/34 , A61M25/10 , A61B17/02 , A61B17/00 , A61B17/22 , A61B17/32 , A61B18/00 , A61M25/00 , A61M25/01
CPC分类号： A61B17/3478 , A61B17/02 , A61B90/37 , A61B2017/00247 , A61B2017/22061 , A61B2017/320044 , A61B2018/00392 , A61M25/0026 , A61M25/0084 , A61M25/10 , A61M2025/0166 , A61M2025/1004
摘要： A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.
摘要翻译： 提供了一种方法，包括将输送装置通过血管壁引入邻近冠状血管的周围空间或心包膜内的治疗部位，并通过输送装置输送治疗剂。 治疗剂通过输送装置根据液压解剖周围空间内的组织平面的条件递送。 提供了一种试剂盒，其包括具有针头的输送装置，所述针头通过心脏的心外膜和冠状血管的壁之一进入周围空间，以及包含平均直径为 15微米或更多，以通过输送装置输送到周围空间。
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公开(公告)号：US08641666B2
公开(公告)日：2014-02-04
申请号：US11749665
申请日：2007-05-16
CPC分类号： A61M25/0082 , A61M25/01 , A61M2025/0004 , A61M2025/0073 , A61M2206/11
摘要： Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed.
摘要翻译： 公开了具有层流生物活性剂递送性质的导管和用于治疗或预防血管疾病的方法。
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公开(公告)号：US20120203174A1
公开(公告)日：2012-08-09
申请号：US13446761
申请日：2012-04-13
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
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公开(公告)号：US08216209B2
公开(公告)日：2012-07-10
申请号：US11756376
申请日：2007-05-31
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/013 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/40 , A61L2300/432 , A61L2300/62 , A61L2430/26 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105
摘要： A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
摘要翻译： 描述了一种方法，包括将递送装置引入肾动脉或肾节段动脉内的点，并根据产生湍流血流的条件从递送装置输送治疗剂，并且其中处理剂能够抑制生物 造成肾病的过程。 在其它实施方案中，描述了一种装置和试剂盒，其包括用于插入肾动脉或肾节段动脉内的点的递送装置和递送能够抑制造成肾病的生物过程的处理剂。
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公开(公告)号：US20110190698A1
公开(公告)日：2011-08-04
申请号：US12902405
申请日：2010-10-12
申请人： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolph von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren, JR. , William E. Webler, JR.
发明人： Paul M. Consigny , David C. Gale , Florian Ludwig , Randolph von Oepen , Fozan O. El-Nounou , Pamela A. Kramer-Brown , Travis R. Yribarren, JR. , William E. Webler, JR.
IPC分类号： A61M25/10
摘要： Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.
摘要翻译： 公开了将药物或其它治疗剂局部递送到哺乳动物脉管系统的装置。 这些装置具有几种相关的结构，并被设计成递送药物以促进与流过装置的血液的快速混合。
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公开(公告)号：US5242462A
公开(公告)日：1993-09-07
申请号：US777977
申请日：1991-10-17
申请人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
发明人： Fozan O. El-Nounou , Michael A. Savin , Ronald A. Sahatjian , Michael Weinreich , Thomas F. Kordis
CPC分类号： A61F2/01 , A61F2002/016 , A61F2002/8486 , A61F2230/005 , A61F2230/0067
摘要： A filter device positionable within a blood vessel for trapping blood clots in that vessel, the filter device comprising a head with a plurality of divergent legs each secured at its proximal end, to the head, each leg having a hook arranged at its distal end.Each leg has a radially outwardly directed radius of curvature to create a conical configuration to the filter assembly, while distributing the stress concentration along the length of the bend, so that the elastic limit of the material, stainless steel in this embodiment, is not exceeded, and which permits compact delivery of the filter, and adequate radially directed force to permit slight hook penetration of a vessel wall.
摘要翻译： 一种位于血管内的过滤器装置，用于捕获血管内的血块，该过滤装置包括头部，该头部具有多个分支腿，每个头部在其近端固定到头部，每个腿部具有设置在其远端的钩。 每个支腿具有径向向外指向的曲率半径，以在沿弯曲部分的长度分布应力集中的同时向过滤器组件产生锥形结构，使得不超过本实施例中不锈钢材料的弹性极限 ，并且其允许过滤器的紧密输送和足够的径向力以允许容器壁的轻微的钩子穿透。
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