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公开(公告)号：US08641666B2
公开(公告)日：2014-02-04
申请号：US11749665
申请日：2007-05-16
CPC分类号： A61M25/0082 , A61M25/01 , A61M2025/0004 , A61M2025/0073 , A61M2206/11
摘要： Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed.
摘要翻译： 公开了具有层流生物活性剂递送性质的导管和用于治疗或预防血管疾病的方法。
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公开(公告)号：US20080287911A1
公开(公告)日：2008-11-20
申请号：US11749665
申请日：2007-05-16
IPC分类号： A61M25/01
CPC分类号： A61M25/0082 , A61M25/01 , A61M2025/0004 , A61M2025/0073 , A61M2206/11
摘要： Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed.
摘要翻译： 公开了具有层流生物活性剂递送性质的导管和用于治疗或预防血管疾病的方法。
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公开(公告)号：US20090118700A1
公开(公告)日：2009-05-07
申请号：US11936668
申请日：2007-11-07
申请人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
发明人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
CPC分类号： A61B17/3478 , A61B17/02 , A61B90/37 , A61B2017/00247 , A61B2017/22061 , A61B2017/320044 , A61B2018/00392 , A61M25/0026 , A61M25/0084 , A61M25/10 , A61M2025/0166 , A61M2025/1004
摘要： A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.
摘要翻译： 提供了一种方法，包括将输送装置通过血管壁引入邻近冠状血管的周围空间或心包膜内的治疗部位，并通过输送装置输送治疗剂。 治疗剂通过输送装置根据液压解剖周围空间内的组织平面的条件递送。 提供了一种试剂盒，其包括具有针头的输送装置，所述针头通过心脏的心外膜和冠状血管的壁之一进入周围空间，以及包含平均直径为 15微米或更多，以通过输送装置输送到周围空间。
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4.发明授权Catheter having window and partial balloon covering for dissecting tissue planes and injecting treatment agent to coronary blood vessel 有权导管具有用于解剖组织平面和将治疗剂注射到冠状动脉血管的窗口和部分气囊覆盖物公开(公告)号：US09504491B2
公开(公告)日：2016-11-29
申请号：US11936668
申请日：2007-11-07
申请人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
发明人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
IPC分类号： A61B17/34 , A61M25/10 , A61B17/02 , A61B17/00 , A61B17/22 , A61B17/32 , A61B18/00 , A61M25/00 , A61M25/01
CPC分类号： A61B17/3478 , A61B17/02 , A61B90/37 , A61B2017/00247 , A61B2017/22061 , A61B2017/320044 , A61B2018/00392 , A61M25/0026 , A61M25/0084 , A61M25/10 , A61M2025/0166 , A61M2025/1004
摘要： A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.
摘要翻译： 提供了一种方法，包括将输送装置通过血管壁引入邻近冠状血管的周围空间或心包膜内的治疗部位，并通过输送装置输送治疗剂。 治疗剂通过输送装置根据液压解剖周围空间内的组织平面的条件递送。 提供了一种试剂盒，其包括具有针头的输送装置，所述针头通过心脏的心外膜和冠状血管的壁之一进入周围空间，以及包含平均直径为 15微米或更多，以通过输送装置输送到周围空间。
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公开(公告)号：US08048448B2
公开(公告)日：2011-11-01
申请号：US11454813
申请日：2006-06-15
CPC分类号： A61K9/5115 , A61K9/0009 , A61K9/127 , A61K41/0019 , A61K41/0028
摘要： Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
摘要翻译： 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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公开(公告)号：US09248034B2
公开(公告)日：2016-02-02
申请号：US11210344
申请日：2005-08-23
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/622
摘要： Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed. The devices include a body structure including an active agent, erodable particles acting as a carrier of the active agent, and an erodable binder. The binder releasably binds the particles together such that after implantation the binder erodes to release the particles.
摘要翻译： 公开了用于治疗局部和远端到植入区域的身体障碍的可植入医疗装置。 这些装置包括主体结构，其包括活性剂，作为活性剂的载体的可侵蚀颗粒和可侵蚀的粘合剂。 粘合剂将颗粒可释放地结合在一起，使得在植入之后，粘合剂侵蚀以释放颗粒。
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7.发明授权Methods of forming coating layers for medical devices utilizing flash vaporization 有权利用闪蒸法形成用于医疗器械的涂层的方法公开(公告)号：US08568764B2
公开(公告)日：2013-10-29
申请号：US11445041
申请日：2006-05-31
CPC分类号： A61L31/10 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61M31/002
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
摘要翻译： 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括在从涂料组合物中除去溶剂之前固定活性剂的形态或相分布。 涂层可用于控制活性剂或活性剂的组合的递送。
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公开(公告)号：US08708948B2
公开(公告)日：2014-04-29
申请号：US13401803
申请日：2012-02-21
申请人： Paul Consigny , Gabriel Asongwe , Mary Beth Michaels , Gene Michal , Evgenia Mandrusov , Jeong Lee , Florian N. Ludwig , John Eric Henckel , Joseph J. Sciacca , Ken Bueche , Richard Todd Thornton , Fidel Albert Urrabazo , Daniel Wiegand
发明人： Paul Consigny , Gabriel Asongwe , Mary Beth Michaels , Gene Michal , Evgenia Mandrusov , Jeong Lee , Florian N. Ludwig , John Eric Henckel , Joseph J. Sciacca , Ken Bueche , Richard Todd Thornton , Fidel Albert Urrabazo , Daniel Wiegand
CPC分类号： A61K38/18 , A61K35/545 , A61K38/19 , A61K2300/00
摘要： Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.
摘要翻译： 通过机械，化学和生物学方法和系统，将治疗细胞和药剂移植到生物体的靶位点。
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公开(公告)号：US08888675B2
公开(公告)日：2014-11-18
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00 , A61N1/362 , A61B17/12 , A61B17/064 , A61F2/24 , A61B17/068
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译： 公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。 支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。 锚固体可以将材料层固定到心肌。 可以将多层生物相容性材料分别放置在心室中以形成支架。 在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。
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10.发明授权公开(公告)号：US08735344B2
公开(公告)日：2014-05-27
申请号：US13177476
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。
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