公开(公告)号：US20120107275A1

公开(公告)日：2012-05-03

申请号：US13323692

申请日：2011-12-12

申请人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

发明人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

IPC分类号： A61K31/5025 ,  A61K31/5377 ,  C07D498/04 ,  A61K31/538 ,  A61K38/21 ,  A61P31/00 ,  A61P3/00 ,  A61P5/00 ,  A61P37/00 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US20090124612A1

公开(公告)日：2009-05-14

申请号：US11879034

申请日：2007-07-13

申请人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

发明人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

IPC分类号： A61K31/5377 ,  C07D487/04 ,  C07D471/04 ,  A61P35/04 ,  A61K31/437 ,  A61K31/5025

CPC分类号： C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20090124609A1

公开(公告)日：2009-05-14

申请号：US12009123

申请日：2008-01-15

申请人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

发明人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

IPC分类号： A61K31/538 ,  C07D487/02 ,  A61K31/5025 ,  C07D413/14 ,  A61K31/5377 ,  A61P35/00 ,  C07D471/02 ,  A61K31/437 ,  A61K31/53 ,  C07D265/36

CPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US07531553B2

公开(公告)日：2009-05-12

申请号：US10804915

申请日：2004-03-19

申请人： Lucian V. Di Pietro ,  Jean-Christophe Harmange ,  Benny C. Askew, Jr. ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Joseph L. Kim ,  Vinod F. Patel ,  Michele Potashman ,  Simon van der Plas

发明人： Lucian V. Di Pietro ,  Jean-Christophe Harmange ,  Benny C. Askew, Jr. ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Joseph L. Kim ,  Vinod F. Patel ,  Michele Potashman ,  Simon van der Plas

IPC分类号： A61K31/47 ,  C07D215/00

CPC分类号： C07D401/12 ,  C07D235/30 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20070185171A1

公开(公告)日：2007-08-09

申请号：US11584151

申请日：2006-10-20

申请人： Julie Germain ,  Benny Askew ,  David Bauer ,  Deborah Choquette ,  Lucian Dipietro ,  Russell Graceffa ,  Jean-Christophe Harmange ,  Qi Huang ,  Joseph Kim ,  Daniel La ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Vinod Patel ,  Michele Potashman ,  Babak Riahi ,  Thomas Storz ,  Simon Van Der Plas ,  Kevin Yang ,  Chester Yuan

发明人： Julie Germain ,  Benny Askew ,  David Bauer ,  Deborah Choquette ,  Lucian Dipietro ,  Russell Graceffa ,  Jean-Christophe Harmange ,  Qi Huang ,  Joseph Kim ,  Daniel La ,  Aiwen Li ,  Nobuko Nishimura ,  Rana Nomak ,  Vinod Patel ,  Michele Potashman ,  Babak Riahi ,  Thomas Storz ,  Simon Van Der Plas ,  Kevin Yang ,  Chester Yuan

IPC分类号： C07D209/04 ,  C07D213/16

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US08524900B2

公开(公告)日：2013-09-03

申请号：US13309488

申请日：2011-12-01

申请人： Brian K. Albrecht ,  David Bauer ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie K. Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

发明人： Brian K. Albrecht ,  David Bauer ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Richard T. Lewis ,  Longbin Liu ,  Julia Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie K. Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

IPC分类号： C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/5025 ,  A61K31/4353 ,  A61K31/4523 ,  A61P35/00

CPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US20080234268A1

公开(公告)日：2008-09-25

申请号：US12008241

申请日：2008-01-09

申请人： Shon Booker ,  Noel D'Angelo ,  Julie Germain ,  Jean-Christophe Harmange ,  Tae-Seong Kim ,  Michele Potashman

发明人： Shon Booker ,  Noel D'Angelo ,  Julie Germain ,  Jean-Christophe Harmange ,  Tae-Seong Kim ,  Michele Potashman

IPC分类号： A61K31/416 ,  C07D231/56 ,  C07D217/22 ,  A61K31/47 ,  A61K31/5377 ,  A61P19/02 ,  A61P35/00 ,  A61K31/502 ,  C07D487/04 ,  C07D417/12

CPC分类号： C07D403/12 ,  C07D231/22 ,  C07D231/56 ,  C07D401/12 ,  C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c-Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如c-Met介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US07759344B2

公开(公告)日：2010-07-20

申请号：US12008241

申请日：2008-01-09

申请人： Shon Booker ,  Noel D'Angelo ,  Julie Germain ,  Jean-Christophe Harmange ,  Tae-Seong Kim ,  Michele Potashman

发明人： Shon Booker ,  Noel D'Angelo ,  Julie Germain ,  Jean-Christophe Harmange ,  Tae-Seong Kim ,  Michele Potashman

IPC分类号： A61K31/495 ,  A61K31/4725 ,  A61K31/416 ,  C07D487/04 ,  C07D217/00 ,  C07D231/54

CPC分类号： C07D403/12 ,  C07D231/22 ,  C07D231/56 ,  C07D401/12 ,  C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c-Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如c-Met介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US08217177B2

公开(公告)日：2012-07-10

申请号：US12009123

申请日：2008-01-15

申请人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Alessandro Boezio ,  Deborah Choquette ,  Jean-Christophe Harmange ,  Julia Lohman ,  Michele Potashman

发明人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Alessandro Boezio ,  Deborah Choquette ,  Jean-Christophe Harmange ,  Julia Lohman ,  Michele Potashman

IPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/437 ,  A61P35/00

CPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US20120190666A1

公开(公告)日：2012-07-26

申请号：US13319683

申请日：2010-05-12

申请人： Christiane Bode ,  Alessandro Boezio ,  Alan C. Cheng ,  Deborah Choquette ,  James Robert Coats ,  Katrina Woodin Copeland ,  Hongbing Huang ,  Daniel La ,  Richard Thomas Lewis ,  Hongyu Liao ,  Michele Potashman ,  John Stellwagen ,  Shuyan Yi ,  Mark H. Norman ,  Markian M. Stec ,  Emily Anne Peterson ,  Russell Graceffa

发明人： Christiane Bode ,  Alessandro Boezio ,  Alan C. Cheng ,  Deborah Choquette ,  James Robert Coats ,  Katrina Woodin Copeland ,  Hongbing Huang ,  Daniel La ,  Richard Thomas Lewis ,  Hongyu Liao ,  Michele Potashman ,  John Stellwagen ,  Shuyan Yi ,  Mark H. Norman ,  Markian M. Stec ,  Emily Anne Peterson ,  Russell Graceffa

IPC分类号： A61K31/52 ,  C07D401/14 ,  A61K31/506 ,  A61P35/02 ,  A61K31/53 ,  C07D487/04 ,  A61K31/5377 ,  A61P35/00 ,  C07D473/40 ,  C07D471/04

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

摘要翻译： 本发明提供了PIKK抑制剂，更具体地，mTOR和/或PI3Kα激酶抑制剂的化合物，因此可用于治疗通过抑制激酶可治疗的疾病，特别是PI3激酶，更具体地，mTOR和/或PI3Kα，例如 癌症。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。