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公开(公告)号:US5932701A
公开(公告)日:1999-08-03
申请号:US978458
申请日:1997-11-25
申请人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
发明人: Michael Terence Black , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren
IPC分类号: C12N15/09 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/46 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号: C12N9/1077 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , A61K38/00 , A61K39/00 , C07K2319/00
摘要: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号:US06326462B1
公开(公告)日:2001-12-04
申请号:US09491916
申请日:2000-01-27
申请人: Christine Debouck , Jason Craig Fedon , Deborah Dee Jaworski , Jeffrey Mooney , Leslie Marie Palmer , Christopher Michael Traini , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
发明人: Christine Debouck , Jason Craig Fedon , Deborah Dee Jaworski , Jeffrey Mooney , Leslie Marie Palmer , Christopher Michael Traini , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
IPC分类号: A61K3902
CPC分类号: C12N9/1085 , A61K38/00
摘要: The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号:US06252044B1
公开(公告)日:2001-06-26
申请号:US08977555
申请日:1997-11-25
申请人: Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
发明人: Michael Terance Black , Lisa Kathleen Shilling , Robert King Stodola , Richard Lloyd Warren , Anna Lisa Kosmatka , Richard Oakley Nicholas , Leslie Marie Palmer , Michael Arthur Lonetto , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles
IPC分类号: C07K100
CPC分类号: C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/1205 , C12N9/78 , C12Y205/01009 , C12Y207/01002
摘要: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号:US06287803B1
公开(公告)日:2001-09-11
申请号:US08965130
申请日:1997-11-06
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
IPC分类号: C12N1531
CPC分类号: G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要: The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了编码时代多肽的时代多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
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公开(公告)号:US06346393B1
公开(公告)日:2002-02-12
申请号:US08965087
申请日:1997-11-06
申请人: Jason Craig Fedon , Michael Arthur Lonetto , Leslie Marie Palmer , Martin Rosenberg , Richard Lloyd Warren
发明人: Jason Craig Fedon , Michael Arthur Lonetto , Leslie Marie Palmer , Martin Rosenberg , Richard Lloyd Warren
IPC分类号: C12N1531
摘要: The invention provides RncS polypeptides and DNA (RNA) encoding RncS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RncS polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了RncS多肽和编码RncS多肽的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还提供了利用RncS多肽筛选抗菌化合物的方法。
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公开(公告)号:US06222026B1
公开(公告)日:2001-04-24
申请号:US09149624
申请日:1998-09-08
IPC分类号: C12N1531
CPC分类号: C07K14/31
摘要: The invention provides gcp polypeptides and polynucleotides encoding gcp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gcp polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了gcp多肽和编码gcp多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用gcp多肽筛选抗菌化合物的方法。
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公开(公告)号:US06238882B1
公开(公告)日:2001-05-29
申请号:US09104068
申请日:1998-06-24
申请人: Jason Craig Fedon , Deborah D Jaworski , Howard Kallender , Anna Lisa Lenox , Leslie Marie Palmer , Min Wang
发明人: Jason Craig Fedon , Deborah D Jaworski , Howard Kallender , Anna Lisa Lenox , Leslie Marie Palmer , Min Wang
IPC分类号: C12P2106
CPC分类号: C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00
摘要: The invention provides gidA1 polypeptides and polynucleotides encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidA1 polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供gidA1多肽和编码gidA1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用gidA1多肽筛选抗菌化合物的方法。
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公开(公告)号:US06225098B1
公开(公告)日:2001-05-01
申请号:US08975215
申请日:1997-11-20
IPC分类号: C12N902
CPC分类号: C12N9/0006 , A61K38/00 , A61K39/00
摘要: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了MurB多肽和编码MurB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用MurB多肽筛选抗菌化合物的方法。
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公开(公告)号:US06355463B2
公开(公告)日:2002-03-12
申请号:US09776271
申请日:2001-02-02
IPC分类号: C12N902
CPC分类号: C12N9/0006 , A61K38/00 , A61K39/00
摘要: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了MurB多肽和编码MurB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用MurB多肽筛选抗菌化合物的方法。
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公开(公告)号:US06238887B1
公开(公告)日:2001-05-29
申请号:US09269258
申请日:1999-03-19
申请人: David T Beattie , Robert L Deresiewicz , Adrian M Lowe , Michael A Lonetto , John E Hodgson , Richard O Nicholas , Leslie Marie Palmer , Julie M Pratt
发明人: David T Beattie , Robert L Deresiewicz , Adrian M Lowe , Michael A Lonetto , John E Hodgson , Richard O Nicholas , Leslie Marie Palmer , Julie M Pratt
IPC分类号: C12N1509
摘要: This invention provides frr polypeptides and polynucleotides encoding frr polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing frr polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了编码frr多肽的frr多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用frr多肽筛选抗菌化合物的方法。
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