公开(公告)号：US08007730B2

公开(公告)日：2011-08-30

申请号：US12478787

申请日：2009-06-05

申请人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

发明人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

IPC分类号： G21C1/00 ,  G05B1/00 ,  G05D16/00 ,  B01J19/00

CPC分类号： B01J19/004

摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.

摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。

公开(公告)号：US20150010447A1

公开(公告)日：2015-01-08

申请号：US13936219

申请日：2013-07-08

申请人： Ming-Hsin Li ,  Hsin-Han Hsieh

发明人： Ming-Hsin Li ,  Hsin-Han Hsieh

IPC分类号： C22B58/00

CPC分类号： C22B58/00 ,  C22B3/0004 ,  Y02P10/234

摘要： A method of purification for recycling of gallium-69 isotopes includes processes of proton irradiation and dissolution for a silver alloy plating target with gallium-69. After the proton irradiation and dissolution, a high concentration elution liquid of gallium-69 and germanium-68 is obtained by washing through an ion-exchange resin to filter out gallium-69 solution, followed by neutralizing precipitation, drying, and sintering treatments to obtain a gallium oxide. The gallium oxide can be dissolved to produce a solid target, and the washing processes can be repeated. The solid target after use can be placed in recycling again. This method is not only implemented to reduce the cost of production and comply with recycling notion nowadays, but also enhance efficiency in the practical application of radioisotopes.

公开(公告)号：US08239159B2

公开(公告)日：2012-08-07

申请号：US12569908

申请日：2009-09-30

申请人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

发明人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

IPC分类号： G06F15/00

CPC分类号： G21G1/10 ,  G21G2001/0094

摘要： A method used to yield irradiation product with minimal impurity for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves including 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph including 69Ga(p,2n)68Ge incident energy and reaction cross-sectional area, derive the nuclear reaction cross-sectional area for each group for germanium(Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium(Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group.

摘要翻译： 用于产生镓（Ga）-68 /锗（Ge）-68发生器的固体靶的杂质最小的辐射产物的方法主要包括以下步骤：首先计算电镀镓（Ga）-69的厚度d 坚实的目标; 然后通过包括69 Ga（p，2n）68Ge目标厚度和入射能量与5个不同入射能量剂量的衰减曲线图，得出每个组在衰变后的相应的照射能量剂量Yi; 通过包括69Ga（p，2n）68Ge入射能和反应截面积的图，得出锗（Ge）-68，镓（Ga）-68，锌（Zn）的每个组的核反应截面积 ）-65，计算每组反应截面积的平均反应面积（MRA）; 并选择最大锗（Ge）-68 MRA值和最小镓（Ga）-68和锌（Zn）-65 MRA值; 并为每组的MRA产生所需的默认照射能量。

公开(公告)号：US20110041950A1

公开(公告)日：2011-02-24

申请号：US12543507

申请日：2009-08-19

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： B67C3/02

CPC分类号： B65B3/003

摘要： An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle. The drug pump withdraws the radiopharmaceuticals from the drug bottle to the injection needle and allows the front end of the injection needle activated to go through the injection hole into the syringe and fill the radiopharmaceuticals into the syringe.

摘要翻译： 一种自动放射性药物灌装机主要包括具有执行三维往复运动的激活机构的主单元。 激活机构具有可以被激活以沿着横向X轴往复运动的横向滑块。 在横向滑动器上，有一个垂直滑动件可以垂直延伸并沿横向Y轴往复运动。 注射针位于垂直滑块上，可以被激活以沿着与轴向滑动件垂直的Z轴往复运动。 注射器架位于注射针的移动范围内，以容纳多个注射器，每个注射器都具有注射孔。 药泵具有入口和出口。 入口连接到高剂量放射性药物药瓶。 出口连接到注射针。 药物泵将放射性药物从药瓶抽出到注射针上，并且允许注射针的前端被激活以通过注射孔进入注射器并将放射性药物填充到注射器中。

公开(公告)号：US20070062865A1

公开(公告)日：2007-03-22

申请号：US11601693

申请日：2006-11-20

申请人： Heng-Chuan Wang ,  Ming-Hsin Li ,  Hsu-Wen Tsang ,  Mei-Mao Wu ,  Hsui-Ping Lin

发明人： Heng-Chuan Wang ,  Ming-Hsin Li ,  Hsu-Wen Tsang ,  Mei-Mao Wu ,  Hsui-Ping Lin

IPC分类号： B01D69/02 ,  C12N1/20

CPC分类号： C02F1/5272 ,  C02F3/34 ,  C02F2209/06 ,  C12N1/20

摘要： The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.

摘要翻译： 本发明涉及包含在包含大豆蛋白，葡萄糖，糖蜜和酵母的培养基中培养的芽孢杆菌属细菌的新型絮凝剂。 或者，絮凝剂包括大豆蛋白。 本发明还涉及制备絮凝剂的方法，包括大规模生产的发酵方法，以及在水处理中使用絮凝剂的方法。

公开(公告)号：US6162686A

公开(公告)日：2000-12-19

申请号：US156362

申请日：1998-09-18

申请人： Kuo Ching Huang ,  Tse-Liang Ying ,  Yu-Hua Lee ,  Ming-Hsin Li

发明人： Kuo Ching Huang ,  Tse-Liang Ying ,  Yu-Hua Lee ,  Ming-Hsin Li

IPC分类号： H01L23/525 ,  H01L21/336 ,  H01L21/00 ,  H01L21/331 ,  H01L21/44 ,  H01L21/82

CPC分类号： H01L23/5258 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method of forming a grooved fuse (plug fuse) in the same step that via plugs are formed in the guard ring area 14 and in product device areas. A key point of the invention is to form fuses from the via plug layer, not from the metal layers. Also, key guard rings are formed around the plug guise. The invention can include the following: a semiconductor structure is provided having a fuse area, a guard ring area surrounding the fuse area; and a device area. First and second conductive strips are formed. First and second insulating layers are formed over the first and second conductive strips. Plug contacts and fuse plugs are formed through the first and second insulating layers to the first and second conductive strips. A third insulating layer is formed over the second insulating layer. Metal lines are formed over the third insulating layer in the device area. A fuse via opening is formed in the third insulating layer. A plug fuse is formed in the fuse via opening. A fourth insulating layer is formed over the plug fuse and the third insulating layer. A fuse opening is formed at least partially though the fourth insulating layer over the fuse area.

摘要翻译： 在通过塞子形成在保护环区域14和产品装置区域中的相同步骤中形成带槽保险丝（插头保险丝）的方法。 本发明的一个关键点是从通孔塞层而不是金属层形成保险丝。 此外，围绕插头形状形成关键保护环。 本发明可以包括：提供具有保险丝区域的半导体结构，围绕保险丝区域的保护环区域; 和设备区域。 形成第一和第二导电条。 第一和第二绝缘层形成在第一和第二导电条上。 插头触点和熔丝插头通过第一和第二绝缘层形成到第一和第二导电条。 在第二绝缘层上形成第三绝缘层。 金属线形成在器件区域中的第三绝缘层上。 在第三绝缘层中形成保险丝通孔。 保险丝通过开口形成插头保险丝。 在插头熔断器和第三绝缘层上形成第四绝缘层。 保险丝开口至少部分地通过保险丝区域上的第四绝缘层形成。

公开(公告)号：US11850291B2

公开(公告)日：2023-12-26

申请号：US16663387

申请日：2019-10-25

申请人： Ming-Hsin Li ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

发明人： Ming-Hsin Li ,  Sheng-Nan Lo ,  Shih-Wei Lo ,  Shih-Ying Lee ,  Su-Jung Chen ,  Shih-Min Wang ,  Ming-Wei Chen ,  Wei-Lin Lo

IPC分类号： A61K51/08

CPC分类号： A61K51/088

摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

公开(公告)号：US09468608B2

公开(公告)日：2016-10-18

申请号：US14522583

申请日：2014-10-24

申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

IPC分类号： A61K9/51 ,  A61K31/704

CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

公开(公告)号：US09102997B2

公开(公告)日：2015-08-11

申请号：US13936219

申请日：2013-07-08

申请人： Ming-Hsin Li ,  Hsin-Han Hsieh

发明人： Ming-Hsin Li ,  Hsin-Han Hsieh

IPC分类号： C22B58/00 ,  C22B3/20

CPC分类号： C22B58/00 ,  C22B3/0004 ,  Y02P10/234

摘要： A method of purification for recycling of gallium-69 isotopes includes processes of proton irradiation and dissolution for a silver alloy plating target with gallium-69. After the proton irradiation and dissolution, a high concentration elution liquid of gallium-69 and germanium-68 is obtained by washing through an ion-exchange resin to filter out gallium-69 solution, followed by neutralizing precipitation, drying, and sintering treatments to obtain a gallium oxide. The gallium oxide can be dissolved to produce a solid target, and the washing processes can be repeated. The solid target after use can be placed in recycling again. This method is not only implemented to reduce the cost of production and comply with recycling notion nowadays, but also enhance efficiency in the practical application of radioisotopes.

摘要翻译： 用于再生镓-69同位素的纯化方法包括用镓-69的银合金电镀靶的质子照射和溶解的方法。 在质子照射和溶解后，通过离子交换树脂洗涤以过滤出镓-69溶液，然后中和沉淀，干燥和烧结处理获得镓-69和锗-68的高浓度洗脱液，获得 氧化镓。 可以溶解氧化镓以制备固体靶，并且可以重复洗涤过程。 使用后的固体靶可再次放回再生。 这种方法不仅实现了降低生产成本，符合现代回收利用理念，而且提高了放射性同位素实际应用的效率。

公开(公告)号：US20150097943A1

公开(公告)日：2015-04-09

申请号：US14049228

申请日：2013-10-09

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： H04N7/18

CPC分类号： H04N7/188 ,  G01N21/84 ,  G01N23/00

摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.

摘要翻译： 本发明涉及包括至少一个CCD照相机，多个放射性检测器，逻辑控制装置，计算机接口控制装置的放射性药物自动合成装置的实时微热电池图像控制系统。 多个放射性检测器连接到逻辑控制装置，并且当所检测的放射性值大于用于选择最近的CCD照相机并发送的阈值时，逻辑控制装置将相应的位置代码发送到计算机接口控制装置 将位置的图像映射到计算机接口控制装置，用于监视放射性药物的自动生产线是否保持正常操作。