公开(公告)号：US20070062865A1

公开(公告)日：2007-03-22

申请号：US11601693

申请日：2006-11-20

申请人： Heng-Chuan Wang ,  Ming-Hsin Li ,  Hsu-Wen Tsang ,  Mei-Mao Wu ,  Hsui-Ping Lin

发明人： Heng-Chuan Wang ,  Ming-Hsin Li ,  Hsu-Wen Tsang ,  Mei-Mao Wu ,  Hsui-Ping Lin

IPC分类号： B01D69/02 ,  C12N1/20

CPC分类号： C02F1/5272 ,  C02F3/34 ,  C02F2209/06 ,  C12N1/20

摘要： The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.

摘要翻译： 本发明涉及包含在包含大豆蛋白，葡萄糖，糖蜜和酵母的培养基中培养的芽孢杆菌属细菌的新型絮凝剂。 或者，絮凝剂包括大豆蛋白。 本发明还涉及制备絮凝剂的方法，包括大规模生产的发酵方法，以及在水处理中使用絮凝剂的方法。

公开(公告)号：US09707521B2

公开(公告)日：2017-07-18

申请号：US13956375

申请日：2013-08-01

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： B01D65/10 ,  G01M3/06

CPC分类号： B01D65/102 ,  B01D65/10 ,  G01M3/06

摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.

公开(公告)号：US20160113884A1

公开(公告)日：2016-04-28

申请号：US14522583

申请日：2014-10-24

申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

IPC分类号： A61K9/51 ,  A61K31/704

CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。

公开(公告)号：US09277192B2

公开(公告)日：2016-03-01

申请号：US14049228

申请日：2013-10-09

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： H04N7/18 ,  G01N23/00 ,  G01N21/84

CPC分类号： H04N7/188 ,  G01N21/84 ,  G01N23/00

摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.

公开(公告)号：US08802014B2

公开(公告)日：2014-08-12

申请号：US13252195

申请日：2011-10-03

申请人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

发明人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

IPC分类号： G21G4/08 ,  G21G1/00

CPC分类号： G21G4/08 ,  A61K51/02 ,  G21G1/0005 ,  G21G2001/0021 ,  Y10S422/903

摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.

摘要翻译： 本发明涉及Ga-68放射性核素发生器的新型结构。 它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。 本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液 柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。

公开(公告)号：US08007730B2

公开(公告)日：2011-08-30

申请号：US12478787

申请日：2009-06-05

申请人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

发明人： Ming-Hsin Li ,  Hsin-EII Wang ,  Chun-Yi Wu ,  Wuu-Jyh Lin

IPC分类号： G21C1/00 ,  G05B1/00 ,  G05D16/00 ,  B01J19/00

CPC分类号： B01J19/004

摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.

摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。

公开(公告)号：US09468608B2

公开(公告)日：2016-10-18

申请号：US14522583

申请日：2014-10-24

申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

IPC分类号： A61K9/51 ,  A61K31/704

CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

公开(公告)号：US09102997B2

公开(公告)日：2015-08-11

申请号：US13936219

申请日：2013-07-08

申请人： Ming-Hsin Li ,  Hsin-Han Hsieh

发明人： Ming-Hsin Li ,  Hsin-Han Hsieh

IPC分类号： C22B58/00 ,  C22B3/20

CPC分类号： C22B58/00 ,  C22B3/0004 ,  Y02P10/234

摘要： A method of purification for recycling of gallium-69 isotopes includes processes of proton irradiation and dissolution for a silver alloy plating target with gallium-69. After the proton irradiation and dissolution, a high concentration elution liquid of gallium-69 and germanium-68 is obtained by washing through an ion-exchange resin to filter out gallium-69 solution, followed by neutralizing precipitation, drying, and sintering treatments to obtain a gallium oxide. The gallium oxide can be dissolved to produce a solid target, and the washing processes can be repeated. The solid target after use can be placed in recycling again. This method is not only implemented to reduce the cost of production and comply with recycling notion nowadays, but also enhance efficiency in the practical application of radioisotopes.

摘要翻译： 用于再生镓-69同位素的纯化方法包括用镓-69的银合金电镀靶的质子照射和溶解的方法。 在质子照射和溶解后，通过离子交换树脂洗涤以过滤出镓-69溶液，然后中和沉淀，干燥和烧结处理获得镓-69和锗-68的高浓度洗脱液，获得 氧化镓。 可以溶解氧化镓以制备固体靶，并且可以重复洗涤过程。 使用后的固体靶可再次放回再生。 这种方法不仅实现了降低生产成本，符合现代回收利用理念，而且提高了放射性同位素实际应用的效率。

公开(公告)号：US20150097943A1

公开(公告)日：2015-04-09

申请号：US14049228

申请日：2013-10-09

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： H04N7/18

CPC分类号： H04N7/188 ,  G01N21/84 ,  G01N23/00

摘要： The present invention relates to a system of real time micro hot cell image control for radiopharmaceutical automatic synthesizing apparatus including at least one CCD camera, a plurality of radioactivity detector, a logic control device, a computer interface control device. The plurality of radioactivity detector are connected to the logic control device, and the logic control device sends a corresponding location code to the computer interface control device when the detected radioactivity value is greater than the threshold value for selecting a nearest CCD camera and sending the taken image of the location to the computer interface control device for monitoring whether the automatic production line of radiopharmaceuticals is kept in normal operation.

摘要翻译： 本发明涉及包括至少一个CCD照相机，多个放射性检测器，逻辑控制装置，计算机接口控制装置的放射性药物自动合成装置的实时微热电池图像控制系统。 多个放射性检测器连接到逻辑控制装置，并且当所检测的放射性值大于用于选择最近的CCD照相机并发送的阈值时，逻辑控制装置将相应的位置代码发送到计算机接口控制装置 将位置的图像映射到计算机接口控制装置，用于监视放射性药物的自动生产线是否保持正常操作。

公开(公告)号：US20140377169A1

公开(公告)日：2014-12-25

申请号：US13921217

申请日：2013-06-19

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： B01J19/00 ,  A61K51/12

CPC分类号： B01J19/004 ,  A61K51/1234 ,  C07B59/001

摘要： An automated synthesis device to produce Re-188-BMEDA solution including: a plurality of reagent vials, three-way solenoid valves, gel filtration columns and micro pumps, and a reaction vial, a product vial, a temporary storage vial, a filter membrane, and a waste vial, wherein the plurality of reagent vials include first reagent vial and second reagent vials being connected to the reaction vial through first micro pump, the third reagent vial and fourth reagent vial being connected to the reaction vial through second micro pump, fifth reagent vial being connected to the reaction vial through third micro pump, and sixth reagent vial being connected to the temporary storage vial through fourth micro pump, wherein the reaction vial is connected to the plurality of gel filtration columns through the micro-pump, respectively. The automated synthesis device is operable with program to upgrade yield and avoid contamination.

摘要翻译： 一种用于生产Re-188-BMEDA溶液的自动化合成装置，包括：多个试剂瓶，三通电磁阀，凝胶过滤柱和微型泵，以及反应瓶，产品小瓶，临时储存小瓶，过滤膜 以及废物小瓶，其中所述多个试剂小瓶包括通过第一微泵连接到所述反应小瓶的第一试剂小瓶和第二试剂小瓶，所述第三试剂小瓶和第四试剂小瓶通过第二微泵连接到所述反应小瓶， 第五试剂小瓶通过第三微泵连接到反应小瓶，第六试剂小瓶通过第四微泵连接到临时存储小瓶，其中反应小瓶分别通过微型泵连接到多个凝胶过滤柱 。 自动合成装置可与程序一起操作，以提高产量并避免污染。