利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

41 条记录 (耗时 0.025 秒)

    Particulate pharmaceutical composition
    11.
    发明授权
    Particulate pharmaceutical composition 有权
    颗粒状药物组成

    公开(公告)号：US09198860B2

    公开(公告)日：2015-12-01

    申请号：US13122546

    申请日：2011-02-14

    申请人： Atsushi Ishii ,  Yasuki Kato

    发明人： Atsushi Ishii ,  Yasuki Kato

    IPC分类号： A61K9/14 ,  A61K31/7088 ,  A61K38/02 ,  A61K9/107 ,  A61K31/7084 ,  A61K9/16 ,  A61K9/19 ,  A61K47/24 ,  A61K47/34

    CPC分类号： A61K9/1075 ,  A61K9/16 ,  A61K9/19 ,  A61K31/7084 ,  A61K31/713 ,  A61K47/24 ,  A61K47/34

    摘要： The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.

    摘要翻译： 本发明提供了具有改善的药物包封稳定性并且适合于药物递送系统的颗粒药物组合物。 颗粒状药物组合物1包含：径向配置的多个嵌段共聚物单元2，其各自具有径向配置的疏水性聚合物链段2b和位于径向外侧的亲水性聚合物链段2a; 包括生物大分子的药物4; 和带电荷的脂质3，其具有与药物4的电荷相反的电荷; 其中带电脂质3被吸引到疏水聚合物链段2b，并且药物3位于疏水性聚合物链段2b的径向内侧。 药物组合物1可以有效地防止药物4与粒子分离。

    Method of Producing Coated Fine Particles
    14.
    发明申请
    Method of Producing Coated Fine Particles 审中-公开
    生产涂层微粒的方法

    公开(公告)号：US20080226704A1

    公开(公告)日：2008-09-18

    申请号：US10593723

    申请日：2005-03-23

    申请人： Makoto Kigoshi ,  Nobuhiro Yagi ,  Yasuki Kato

    发明人： Makoto Kigoshi ,  Nobuhiro Yagi ,  Yasuki Kato

    IPC分类号： A61K9/127 ,  B05D7/00 ,  B32B5/16 ,  A61K9/50

    CPC分类号： B01J13/02 ,  Y10T428/2989

    摘要： The present invention provides a method of producing coated fine particles in which core fine particles is coated with a coating layer, which comprises the steps of preparing a liquid (liquid A) containing a polar organic solvent in which core fine particles are dispersed and a component constituting a coating layer is dissolved; preparing a liquid (liquid B) which is miscible with the liquid A and does not contain a polar organic solvent or contains a polar organic solvent in a ratio lower than that in the liquid A; and letting the liquid A flow from at least one inlet of a device for producing coated fine particles equipped with an in-line mixing means having two or more inlets and one or more outlet(s) and letting the liquid B flow from at least one remaining inlet to mix the liquids thereby coating the core fine particles with the coating layer.

    摘要翻译： 本发明提供一种制备其中芯细颗粒涂覆有涂层的涂覆微粒的方法，该方法包括以下步骤：制备包含其中分散芯细颗粒的极性有机溶剂的液体（液体A）和组分 构成涂层溶解; 制备与液体A混溶并且不含极性有机溶剂或含有比液体A中的比例低的极性有机溶剂的液体（液体B）; 并且使液体A从用于生产包含具有两个或更多个入口和一个或多个出口的直列混合装置的涂覆微粒的装置的至少一个入口流出并使液体B从至少一个流出 剩余的入口混合液体，从而涂覆核心微粒与涂层。

    Method Of Producing Coated Fine Particles
    15.
    发明申请
    Method Of Producing Coated Fine Particles 审中-公开
    生产涂层微粒的方法

    公开(公告)号：US20080171090A1

    公开(公告)日：2008-07-17

    申请号：US11883165

    申请日：2006-01-27

    申请人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    发明人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    IPC分类号： A61K9/14 ,  A61J3/00 ,  A61P35/00 ,  A61P29/00 ,  B32B1/00

    CPC分类号： A61K9/5123 ,  A61K9/1075 ,  A61K9/5192 ,  A61K31/7088 ,  B01J13/04 ,  Y10T428/2991

    摘要： An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component(s) can be in the dispersed state in the liquid, and the like.

    摘要翻译： 本发明的目的是提供一种容易地生产其中芯细颗粒涂覆有涂层组分等的涂覆微粒的方法。提供了一种制备涂覆微粒的方法，其包括涂覆有涂层的芯细颗粒 包括以下步骤：将芯细颗粒和涂层组分分散在液体中，以及用芯层细颗粒涂覆涂层组分的方法，其中液体含有极性有机溶剂，其中涂层 层组分是可溶的，并且极性有机溶剂的浓度使得芯细颗粒不溶解，并且涂层组分可以在液体中处于分散状态等。

    Particulate composition and pharmaceutical composition containing the same
    16.
    发明授权
    Particulate composition and pharmaceutical composition containing the same 有权
    颗粒组成和含有它的药物组合物

    公开(公告)号：US09415059B2

    公开(公告)日：2016-08-16

    申请号：US13381841

    申请日：2010-08-31

    申请人： Yasuki Kato ,  Atsushi Ishii

    发明人： Yasuki Kato ,  Atsushi Ishii

    IPC分类号： A61K38/16 ,  A61K31/7088 ,  A61K9/107 ,  A61K9/127 ,  A61K31/715 ,  A61K38/38 ,  C12N15/88

    CPC分类号： A61K31/7088 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/715 ,  A61K38/38 ,  C12N15/88

    摘要： The present invention provides a particulate composition containing: block copolymer units being arranged radially with hydrophobic polymer-chain segments radially inside and hydrophilic polymer-chain segments radially outside; and a charged lipid which carries a charge opposite to the charge of a drug to be encapsulated, the charged lipid being attracted to the hydrophobic polymer-chain segment. In this particulate composition, the drug is retained within the particle via electrostatic binding with the charged lipid, whereby the outer surface of the particle is prevented from being charged to attract a substance which has a charge opposite to that of the charged lipid.

    摘要翻译： 本发明提供了一种颗粒组合物，其含有：径向排列有疏水性聚合物链段的径向外侧和亲水性聚合物链段径向外侧的嵌段共聚物单元; 和带电脂质，其带有与要包封的药物的电荷相反的电荷，带电脂质被吸引到疏水性聚合物链段。 在该颗粒组合物中，药物通过与带电脂质的静电结合而保留在颗粒内，从而防止颗粒的外表面被带电以吸引具有与带电脂质相反的电荷的物质。

    METHOD OF PRODUCING COATED FINE PARTICLES
    17.
    发明申请
    METHOD OF PRODUCING COATED FINE PARTICLES 审中-公开
    生产涂层精细颗粒的方法

    公开(公告)号：US20120301539A1

    公开(公告)日：2012-11-29

    申请号：US13565078

    申请日：2012-08-02

    申请人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    发明人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    IPC分类号： A61K9/14 ,  A61K31/7105 ,  A61K31/713 ,  A61K9/127 ,  A61K31/711

    CPC分类号： A61K9/5123 ,  A61K9/1075 ,  A61K9/5192 ,  A61K31/7088 ,  B01J13/04 ,  Y10T428/2991

    摘要： An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component (s) can be in the dispersed state in the liquid, and the like.

    摘要翻译： 本发明的目的是提供一种容易地生产其中芯细颗粒涂覆有涂层组分等的涂覆微粒的方法。提供了一种制备涂覆微粒的方法，其包括涂覆有涂层的芯细颗粒 包括以下步骤：将芯细颗粒和涂层组分分散在液体中，以及用芯层细颗粒涂覆涂层组分的方法，其中液体含有极性有机溶剂，其中涂层 层组分是可溶的，并且极性有机溶剂的浓度使得芯细颗粒不溶解，并且涂层组分可以在液体中处于分散状态等。