公开(公告)号：US5294532A

公开(公告)日：1994-03-15

申请号：US945922

申请日：1992-09-17

申请人： Tadashi Ito ,  Takanori Hioki ,  Akihiko Ikegawa

发明人： Tadashi Ito ,  Takanori Hioki ,  Akihiko Ikegawa

IPC分类号： G03C1/09 ,  G03C1/18 ,  G03C1/29

CPC分类号： G03C1/29 ,  G03C1/09 ,  G03C1/18 ,  G03C2001/03517 ,  G03C2001/03535 ,  G03C2001/093 ,  G03C2007/3025 ,  G03C2200/27 ,  G03C2200/34 ,  G03C2200/39 ,  G03C2200/45 ,  G03C2200/52

摘要： Disclosed is a silver halide photographic material for medical use, in which the coated amount of silver per surface of the support is 2.8 g/m.sup.2 or less, the silver halide grains in the coated silver halide emulsion layer have a silver chloride content of 10 to 50 mol %, they contain 10.sup.-8 mol or more, per mol of silver, of an iridium compound and they have been spectrally-sensitized to be sensitive to rays of from 600 to 700 nm wavelength range. The material may be processed by rapid processing and has a high sensitivity and high covering power. Also disclosed is a silver halide photographic material for laser exposure, in which the emulsion contains 10.sup.-8 mol or more, per mol of silver, of an iridium compound and is spectrally-sensitized with a sensitizing dye of formula (III): ##STR1## where V.sub.1, V.sub.2, V.sub.3, V.sub.4, V.sub.5, V.sub.6, V.sub.7 and V.sub.8 each represent a hydrogen atom or a monovalent substituent, and they satisfy the following conditions:where f value of Vk (k=1 to 8) is Vkf,A.sub.1 =V.sub.1 f+V.sub.2 f+V.sub.3 f+V.sub.4 f, andA.sub.2 =V.sub.5 f+V.sub.6 f+V.sub.7 f+V.sub.8 f;then A.sub.1

摘要翻译： 公开了用于医​​疗用途的卤化银照相材料，其中每个表面的银的涂布量为2.8g / m 2以下，涂覆的卤化银乳剂层中的卤化银颗粒的氯化银含量为10〜 50摩尔％，它们含有10-8摩尔或更多的每摩尔银铱化合物，并且它们已被光谱增感以对于600-700nm波长范围的光敏感。 该材料可以通过快速加工处理，并且具有高灵敏度和高覆盖力。 还公开了一种用于激光曝光的卤化银照相材料，其中乳液每摩尔银含有10-8摩尔或更多的铱化合物，并用式（III）的敏化染料进行光谱增感：（* 化学结构*）（III）其中V1，V2，V3，V4，V5，V6，V7和V8各自表示氢原子或一价取代基，它们满足以下条件：其中V k（k = 1〜 8）是Vkf，A1 = V1f + V2f + V3f + V4f，A2 = V5f + V6f + V7f + V8f; 那么A1 <1.63，或A2 <1.63; R1和R2各自表示取代或未取代的烷基; L1，L2和L3各自表示取代或未取代的次甲基; M1表示电荷中和对离子; m1是中和分子的电荷所必需的0以上的数。 这具有高灵敏度，并且可以通过超快速处理系统处理，导致处理材料中的残留颜色很少。

公开(公告)号：US4960683A

公开(公告)日：1990-10-02

申请号：US212995

申请日：1988-06-29

申请人： Masaki Okazaki ,  Akihiko Ikegawa ,  Minoeu Yamada ,  Kunio Steo

发明人： Masaki Okazaki ,  Akihiko Ikegawa ,  Minoeu Yamada ,  Kunio Steo

IPC分类号： G03C5/26 ,  G03C5/38

CPC分类号： G03C5/38 ,  G03C5/268

摘要： A method for processing a black-and-white photosensitive material comprising the steps of:(a) exposing a silver halide photosensitive material having been spectrally sensitized with a sensitizing dye;(b) developing the exposed material;(c) fixing the developed material; and(d) thereafter at least one step selected from washing the material and stabilizing the material;at least one of the fixing, washing and stabilizing steps being performed in the presence of at least one compound represented by formula (I) or (II) or a salt thereof; ##STR1## wherein A represents an atomic group necessary for forming a saturated or unsaturated 3-membered to 8-membered ring comprising at least one hetero atom selected from an oxygen atom, a nitrogen atom, a sulfur atom and a selenium atom; and M represents a hydrogen atom or a counter cation; andX--(R.sub.1 --S).sub.n --R.sub.2 --S--R.sub.3 --Y (II)wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkylene group; R.sub.1 and R.sub.3 may be linked to form a ring, R.sub.2 and R.sub.3 may be linked to form a ring; X and Y, which may be the same or different, each represents a hydrogen atom, an alkyl group, an amino group, an ammonio group, a hydroxyl group, a carboxyl group, a sulfo group, an aminocarbonyl group or an aminosulfonyl group, and X and Y may be linked to form a ring; and n is an integer of from 0 to 10.

摘要翻译： 一种用于处理黑白感光材料的方法，包括以下步骤：（a）用敏化染料曝光已被光谱增感的卤化银感光材料; （b）开发暴露的材料; （c）固定开发材料; 和（d）此后，选择洗涤材料和稳定材料的至少一个步骤; 在至少一种由式（I）或（II）表示的化合物或其盐的存在下进行固定，洗涤和稳定步骤中的至少一个; （I）其中A表示形成饱和或不饱和的3元至8元环所必需的原子团，其包含至少一个选自氧原子，氮原子，硫原子和硒原子的杂原子 ; M表示氢原子或抗衡阳离子; 和X - （R 1 -S）n -R 2 -S-R 3 -Y（II）其中R 1，R 2和R 3可以相同或不同，各自表示亚烷基; R 1和R 3可以连接形成环，R 2和R 3可以连接形成环; X和Y可以相同或不同，分别表示氢原子，烷基，氨基，氨基，羟基，羧基，磺基，氨基羰基或氨基磺酰基， X和Y可以连接形成环; n为0〜10的整数。

公开(公告)号：US5437972A

公开(公告)日：1995-08-01

申请号：US187012

申请日：1994-01-27

申请人： Akihiko Ikegawa ,  Masayuki Kuramitsu ,  Masaki Okazaki

发明人： Akihiko Ikegawa ,  Masayuki Kuramitsu ,  Masaki Okazaki

IPC分类号： G03C1/14 ,  G03C1/18 ,  G03C1/29

CPC分类号： G03C1/18

摘要： Disclosed is a novel silver halide photographic material comprising a support having thereon (a) a layer containing at least one methine compound represented by the following general formula (I) and (b) a layer containing at least one methine compound represented by the following general formula (II), (III), (IV) or (V): ##STR1## wherein the variables in the formulas are defined in the detailed description. In a preferred embodiment, the silver halide photographic material comprises at least one methine compound represented by general formula (I) and at least one methine compound represented by general formula (II) or (V) in the same layer.

摘要翻译： 公开了一种新型的卤化银照相材料，其包含其上具有的载体（a）包含至少一种由以下通式（I）表示的次甲基化合物的层和（b）含有至少一种以下通式 式（II），（III），（IV）或（V）：其中式中的变量在详细描述中定义。 在优选的实施方案中，卤化银照相材料在同一层中包含至少一种由通式（I）表示的次甲基化合物和至少一种由通式（II）或（V）表示的次甲基化合物。

公开(公告)号：US5364755A

公开(公告)日：1994-11-15

申请号：US47496

申请日：1993-04-16

申请人： Yasushi Miyamoto ,  Akihiko Ikegawa

发明人： Yasushi Miyamoto ,  Akihiko Ikegawa

IPC分类号： G03C1/09 ,  G03C1/12 ,  G03C1/14 ,  G03C1/16 ,  G03C1/18

CPC分类号： G03C1/09 ,  G03C1/12

摘要： A silver halide photographic light-sensitive material have at least one silver halide emulsion layer on a support, wherein at least one of the silver halide emulsion layers comprises an emulsion subjected to chemical sensitization with a selenium compound and spectral sensitization with at least one type of a methine compound represented by Formula (I) below: ##STR1## wherein R.sup.1 represents --(CH.sub.2).sub.r --CONHSO.sub.2 --R.sub.3, --(CH.sub.2).sub.s --SO.sub.2 NHCO--R.sup.4, --(CH.sub.2).sub.t --CONHCO--R.sup.5, or --(CH.sub.2).sub.u --SO.sub.2 NHSO.sub.2 --R.sup.6 ; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 each represent an alkyl group, an alkoxy group, or an amino group; R.sup.2 has the same meaning as R.sup.1 or represents an alkyl group; Z.sup.1 and Z.sup.2 each represent a nonmetal atom group required to form a 5- or 6-membered heterocyclic ring; each of L.sub.1, L.sub.2, and L.sub.3 represents a methine group; X.sub.1 represents anion; r, s, t, and u each represent an integer from 1 to 5; each of p and q represents 0 or 1; m represents 0, 1, or 2; and k represents a number required to adjust the charge in the molecule to 0.

摘要翻译： 卤化银照相感光材料在载体上具有至少一个卤化银乳剂层，其中至少一种卤化银乳剂层包含用硒化合物进行化学增感的乳液和至少一种 （I）表示的次甲基化合物：其中R 1表示 - （CH 2）r-CONHSO 2 -R 3， - （CH 2）s -SO 2 NHCO-R 4， - （CH 2）t CONHCO-R 5 ，或 - （CH 2）u -SO 2 NHSO 2 -R 6; R3，R4，R5和R6各自表示烷基，烷氧基或氨基; R2具有与R 1相同的含义或表示烷基; Z 1和Z 2各自表示形成5或6元杂环所需的非金属原子团; L1，L2和L3中的每一个代表次甲基; X1表示阴离子; r，s，t和u分别表示1〜5的整数， p和q各自表示0或1; m表示0,1或2; k表示将分子中的电荷调整为0所需的数。

公开(公告)号：US5108888A

公开(公告)日：1992-04-28

申请号：US567573

申请日：1990-08-15

申请人： Akihiko Ikegawa ,  Masaki Okazaki ,  Junji Nishigaki

发明人： Akihiko Ikegawa ,  Masaki Okazaki ,  Junji Nishigaki

IPC分类号： G03C1/06 ,  G03C7/305

CPC分类号： G03C1/06 ,  G03C7/305 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/164

摘要： A silver halide photographic material comprising a support and at least one silver halide emulsion layer on the support, wherein at least one compound represented by general formula (I) is contained in the silver halide emulsion layer or another hydrophilic colloid layer:A--B m(I)wherein A represents a blocking group capable of releasing B during processing, and B represents a group capable of releasing a residual color improving agent which satisfies Condition 1 after being released from A--B, and is linked to A via a hetero atom in B.Condition 1:When a 2 ml aqueous solution of 4.0.times.10.sup.-4 mole/l of anyhydro-5,5'-dichloro-9-ethyl-3,3'-bis(3-sulfopropyl)-thiacarbocyanine hydroxide.pyridinium salt is mixed with a 1 ml aqueous solution of 1.0.times.10.sup.-1 mole/l of potassium chloride, and 4 ml of an aqueous solution of 8.0.times.10.sup.-2 mol/l of the residual color improving agent are further added to this mixture, which is then diluted with water to a set volume of 10 ml to form a diluted aqueous solution, the molecular extinction coefficient of this diluted aqueous solution at 624 nm is 1.0.times.10.sup.5 or less.

公开(公告)号：US5008181A

公开(公告)日：1991-04-16

申请号：US248747

申请日：1988-09-26

申请人： Akihiko Ikegawa ,  Masaki Okazaki ,  Tadao Sugimoto

发明人： Akihiko Ikegawa ,  Masaki Okazaki ,  Tadao Sugimoto

IPC分类号： G03C1/12 ,  G03C1/06 ,  G03C1/10 ,  G03C1/28 ,  G03C7/305 ,  G03C7/32

CPC分类号： G03C1/28 ,  Y10S430/156 ,  Y10S430/159

摘要： A silver halide photographic material comprising a support having thereon at least one silver halide emulsion layer spectrally sensitized by at least one adsorptive spectral sensitizing dye, wherein the emulsion layer or a hydrophilic colloid layer adjacent to the emulsion layer contains at least one compound represented by following formula (I), (II), or (III); ##STR1##A.sub.2 --Time.sub.1).sub..sbsb.t.sbsb.1 X (II)A.sub.3 --Time.sub.2).sub.t.sbsb.2 Y (III)(all the symbols of which are defined in the specification) are disclosed.

摘要翻译： 一种卤化银照相材料，包括其上具有至少一种由至少一种吸附光谱增感染料光谱增感的卤化银乳剂层的载体，其中所述乳剂层或邻近所述乳剂层的亲水胶体层含有至少一种以下化合物 式（I），（II）或（III）; （I）A2-Time1）t1X（II）A3-Time2）t2Y（III）（其全部符号在说明书中定义）。

公开(公告)号：US20070274983A1

公开(公告)日：2007-11-29

申请号：US11574123

申请日：2005-08-24

申请人： Sebastianus Gerardus Kluijtmans ,  Akihiko Ikegawa ,  Jan Bouwstra

发明人： Sebastianus Gerardus Kluijtmans ,  Akihiko Ikegawa ,  Jan Bouwstra

IPC分类号： A61K39/395

CPC分类号： A61K31/702 ,  A23L33/12 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2300/29 ,  A61K31/202 ,  A61K31/733 ,  A61K35/741 ,  A61K39/42 ,  A61K2300/00 ,  A23V2200/324 ,  A23V2250/28 ,  A23V2250/608 ,  A23V2250/304 ,  A23V2250/1642 ,  A23V2250/1882 ,  A23V2200/3202 ,  A23V2200/3204

摘要： The present invention provides a method and composition for the treatment and/or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and immunoglobulin from the milk or colostrum of hyperimmunized cows.

摘要翻译： 本发明提供了用于治疗和/或预防感染的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和来自超免疫母牛的乳或初乳的免疫球蛋白。

公开(公告)号：US06713473B1

公开(公告)日：2004-03-30

申请号：US09926355

申请日：2002-02-19

申请人： Naoyuki Nishikawa ,  Masaharu Sugai ,  Kozo Aoki ,  Makoto Suzuki ,  Akihiko Ikegawa ,  Kazunobu Takahashi ,  Fukuichi Ohsawa ,  Naomi Masuda ,  Nobukazu Kakui ,  Jiro Tanaka ,  Yuji Tabata ,  Kenji Asai

发明人： Naoyuki Nishikawa ,  Masaharu Sugai ,  Kozo Aoki ,  Makoto Suzuki ,  Akihiko Ikegawa ,  Kazunobu Takahashi ,  Fukuichi Ohsawa ,  Naomi Masuda ,  Nobukazu Kakui ,  Jiro Tanaka ,  Yuji Tabata ,  Kenji Asai

IPC分类号： A61K31403

CPC分类号： C07D231/12 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/675 ,  C07D209/88 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07F9/5728 ,  C09B57/00

摘要： A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR3—CO—, —CO—NR3— and the like (R3 represents a hydrogen atom, a lower alkyl group, a lower acyl group and the like); M represents an alkylene linking group (a carbon atom constituting the carbon chain may be replaced with a nitrogen atom, an oxygen atom and the like); X represents —S—, —O—, —NR4—, —NR5—CO— and the like (R4 and R5 represent a hydrogen atom, a lower alkyl group and the like) or a single bond; Y represents an alkyl group, an aryl group, an amino group, an aromatic heterocyclic group and the like; R1 represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a lower acyl group; and R21, R22 and R23 represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like] or a salt thereof. The compound is useful as an active ingredient of medicaments for diseases in which neuropeptide Y is involved, ingestion control for hyperphagia and the like.

摘要翻译： 由式（I）表示的化合物[A表示5-至7-元烃环基团; L代表-NR 3 -CO - ， - CO-NR 3 - 等（R 3表示氢原子，低级烷基，低级酰基等）。 M表示亚烷基连接基（构成碳链的碳原子可以被氮原子，氧原子等取代）; X表示-S - ， - O - ，-NR 4 - ， - NR 5 -CO-等（R 4和R 5表示氢原子，低级烷基等） ）或单一债券; Y表示烷基，芳基，氨基，芳香族杂环基等; R 1表示低级烷基，低级烯基，低级炔基或低级酰基; R 21，R 22和R 23表示氢原子，羟基，低级烷基等〕或其盐。 该化合物可用作其中涉及神经肽Y的疾病的药物的活性成分，用于食欲摄入的摄取控制等。

公开(公告)号：US5618831A

公开(公告)日：1997-04-08

申请号：US242834

申请日：1994-05-16

申请人： Tadao Shishido ,  Masayuki Kawakami ,  Akihiko Ikegawa ,  Toshinao Ukai ,  Keizo Koya ,  Lan B. Chen

发明人： Tadao Shishido ,  Masayuki Kawakami ,  Akihiko Ikegawa ,  Toshinao Ukai ,  Keizo Koya ,  Lan B. Chen

IPC分类号： A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505

CPC分类号： A61K31/541 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506

摘要： A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.

摘要翻译： 一种用于治疗动物癌症的药物组合物，其包含：（A）治疗有效量的至少一种选自由通式（I）表示的化合物的化合物。 （I）其中Z1和Z2可以相同或不同，分别代表形成5-或6-元环所必需的原子团; R 1，R 2和R 3可以相同或不同，表示烷基或芳基; L1和L2各自表示次甲基或取代的次甲基; X表示药学上可接受的阴离子; k表示电荷平衡所需的数字; n表示0或1; 和（B）药学上可接受的载体或稀释剂。

公开(公告)号：US5384234A

公开(公告)日：1995-01-24

申请号：US85174

申请日：1993-07-02

申请人： Fumitaka Ueda ,  Junji Nishigaki ,  Akihiko Ikegawa

发明人： Fumitaka Ueda ,  Junji Nishigaki ,  Akihiko Ikegawa

IPC分类号： G03C1/16 ,  G03C1/14 ,  G03C1/18 ,  G03C1/29 ,  G03C7/305 ,  G03C1/46

CPC分类号： G03C1/29 ,  G03C1/14 ,  G03C7/30529

摘要： The present invention provides a silver halide color photographic photosensitive material which has high saturation, excellent color reproduction and excellent graininess, the material comprising a silver halide emulsion layer which imparts an interlayer effect to a red sensitive silver halide emulsion layer is spectrally sensitized with a sensitizing dye represented by formula (I) and contains a development inhibitor releasing compound represented by formula (II). ##STR1##

摘要翻译： 本发明提供了一种具有高饱和度，优异色彩再现性和优异颗粒性的卤化银彩色照相感光材料，包含赋予红色感光卤化银乳剂层的层间效应的卤化银乳剂层的材料用敏化剂进行光谱增感 由式（I）表示的染料并含有由式（II）表示的显影抑制剂释放化合物。 （I）（II）