公开(公告)号：US11406824B2

公开(公告)日：2022-08-09

申请号：US16218373

申请日：2018-12-12

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Daniel Chao ,  Benjamin Pless ,  Thomas Tcheng

IPC: A61N1/36 ,  A61B5/00 ,  A61N1/05 ,  A61N1/30 ,  A61N5/06 ,  A61B8/08 ,  A61B90/10 ,  A61N1/04 ,  A61N1/20 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

公开(公告)号：US11064926B2

公开(公告)日：2021-07-20

申请号：US15817160

申请日：2017-11-17

Applicant: NeuroPace, Inc.

Inventor： Tara L. Crowder ,  Brett M. Wingeier ,  Martha J. Morrell ,  Felice Sun ,  Thomas Tcheng

IPC: A61B5/00 ,  A61B5/24 ,  A61B5/377 ,  A61B5/145 ,  A61B5/1455

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

公开(公告)号：US09440064B2

公开(公告)日：2016-09-13

申请号：US14223478

申请日：2014-03-24

Applicant: NeuroPace, Inc.

Inventor： Brett Wingeier ,  Daniel Chao ,  Benjamin Pless ,  Thomas Tcheng

IPC: A61B5/00 ,  A61N1/05 ,  A61B8/08 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61N1/30 ,  A61N1/36 ,  A61N5/06

CPC classification number: A61N1/36025 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4094 ,  A61B5/6864 ,  A61B8/0808 ,  A61B18/02 ,  A61B18/14 ,  A61B90/10 ,  A61B2018/1807 ,  A61B2090/103 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/205 ,  A61N1/303 ,  A61N1/36017 ,  A61N5/0601

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract translation: 方法，装置和系统通过将颅骨/脑界面以颅骨形成的孔的形式，颅骨中的天然存在的开窗或经颅通道聚焦刺激源来诱导神经调节。 方法，设备和系统识别在哪里定位颅骨/脑界面，可以与界面一起使用的附件，以及用于控制通过界面传递的刺激的功能。 头颅/脑界面的多种适应症包括诊断和治疗神经障碍和疾病如癫痫，运动障碍，抑郁症，阿尔茨海默病，孤独症，昏迷和疼痛。