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    PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING THE SAME
    14.
    发明申请
    PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING THE SAME 审中-公开
    药物组合物及其生产方法

    公开(公告)号：US20130177594A1

    公开(公告)日：2013-07-11

    申请号：US13733253

    申请日：2013-01-03

    Applicant: NITTO DENKO CORPORATION

    Inventor： Takuya SHISHIDO ,  Daisuke ASARI ,  Mitsuhiko HORI

    IPC: A61K47/36 ,  A61K47/26 ,  A61K47/32 ,  A61K39/36

    CPC classification number: A61K47/36 ,  A61K9/0056 ,  A61K9/19 ,  A61K38/168 ,  A61K39/36 ,  A61K47/26 ,  A61K47/32

    Abstract: The present invention provides a pharmaceutical composition capable of preserving and delivering an allergen having poor thermal stability without using gelatin as a stabilizer, and a method for producing the pharmaceutical composition. The present invention provides a pharmaceutical composition containing an allergen and additives selected from at least two groups from among group (A) consisting of polysaccharides having high formability; group (B) consisting of mono- to hexasaccharides, sugar alcohols thereof, maltodextrin, and polyvinylpyrrolidone; and group (C) consisting of viscous polysaccharides; wherein the additives have a stabilizing effect on the allergen.

    Abstract translation: 本发明提供能够保存并输送热稳定性差的变应原剂而不使用明胶作为稳定剂的药物组合物，以及该药物组合物的制造方法。 本发明提供含有变应原和添加剂的药物组合物，所述组合物选自由具有高成形性的多糖组成的组（A）中的至少两组; 由一至六糖组成的组（B），其糖醇，麦芽糖糊精和聚乙烯吡咯烷酮; 和由粘性多糖组成的组（C）; 其中所述添加剂对变应原具有稳定作用。

    VACCINE PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION
    16.
    发明申请
    VACCINE PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION 有权

    公开(公告)号：US20170216431A1

    公开(公告)日：2017-08-03

    申请号：US15514868

    申请日：2015-10-01

    Applicant: NITTO DENKO CORPORATION

    Inventor： Takuya SHISHIDO ,  Daisuke ASARI ,  Kyohei MATSUSHITA ,  Katsuyuki OKUBO ,  Mitsuhiko HORI

    IPC: A61K39/39 ,  A61K39/02 ,  A61K39/00 ,  A61K9/70

    Abstract: The present invention provides a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent for cancer or infectious diseases, and capable of safely and effectively inducing a systemic immune response. It can be administered to a human or animal skin, the vaccine pharmaceutical composition including: a lipopolysaccharide or its salt derived from at least one gram-negative bacterium such as Serratia, Lelercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, as an immunostimulant; and at least one antigen, the vaccine pharmaceutical composition having a mass ratio between the immunostimulant and the antigen, the total mass of the immunostimulant/the total mass of the antigen, of 0.002 to 500.

    ORAL FILM-FORM BASE AND PREPARATION
    19.
    发明申请
    ORAL FILM-FORM BASE AND PREPARATION 审中-公开
    口腔膜形式和准备

    公开(公告)号：US20130177605A1

    公开(公告)日：2013-07-11

    申请号：US13737255

    申请日：2013-01-09

    Applicant: NITTO DENKO CORPORATION

    Inventor： Daisuke ASARI ,  Mitsuhiko HORI ,  Takuya SHISHIDO

    IPC: A61K9/46

    CPC classification number: A61K9/0007 ,  A61K9/006 ,  A61K47/02

    Abstract: The present invention provides an oral film-form base which has a rapid dissolution profile in the mouth and sufficient film strength, and gives an improved taking property by foaming in the mouth. The oral film-form base includes an edible polymer soluble both in water and in an organic solvent having a solubility parameter of 9.7 or higher, a foaming agent, and an auxiliary foaming agent, wherein the foaming agent is foamable in the presence of water, and the foaming agent and the auxiliary foaming agent each are insoluble in the organic solvent, have an average particle size of 0.1 to 60 μm, and are included in particle states.

    Abstract translation: 本发明提供一种在口中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的底物，并通过在口中发泡获得改进的吸收性能。 口腔膜型基质包括可溶于水和可溶性参数为9.7以上的有机溶剂中的可食用聚合物，发泡剂和辅助发泡剂，其中发泡剂在水的存在下是可发泡的， 发泡剂和辅助发泡剂各自不溶于有机溶剂，平均粒径为0.1〜60μm，并且以颗粒状态包含。

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