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公开(公告)号：US11111545B2
公开(公告)日：2021-09-07
申请号：US17061877
申请日：2020-10-02
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann , Johan Baner , Allison Ryan , Milena Banjevic , Zachary Demko
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6874 , C12Q1/6809
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US11098365B2
公开(公告)日：2021-08-24
申请号：US16747833
申请日：2020-01-21
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6855 , C12Q1/6874
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US11085087B2
公开(公告)日：2021-08-10
申请号：US16359917
申请日：2019-03-20
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G06F19/00 , G16B25/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US10793912B2
公开(公告)日：2020-10-06
申请号：US16399947
申请日：2019-04-30
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Popiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6855 , C12Q1/6874
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US10597723B2
公开(公告)日：2020-03-24
申请号：US16288022
申请日：2019-02-27
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6855 , C12Q1/6874
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20190256916A1
公开(公告)日：2019-08-22
申请号：US16399103
申请日：2019-04-30
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/6883 , C12Q1/6848 , C12Q1/6811
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US10179937B2
公开(公告)日：2019-01-15
申请号：US14692703
申请日：2015-04-21
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： G01N33/48 , C12Q1/6886 , G06F19/20 , G06F19/24 , G06F19/00 , G06N99/00 , G06N7/00 , G16H50/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US20170107576A1
公开(公告)日：2017-04-20
申请号：US14692703
申请日：2015-04-21
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmerman
CPC分类号： C12Q1/6886 , C12Q1/6869 , C12Q2539/10 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G06F19/00 , G06F19/16 , G06F19/20 , G06F19/24 , G06N7/005 , G06N99/005 , G16H10/40 , G16H50/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US11486008B2
公开(公告)日：2022-11-01
申请号：US16014961
申请日：2018-06-21
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/6886 , C12Q1/6869 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/00 , G16B20/20 , G16H50/20 , G06N7/00 , G16H10/40 , G06F19/00 , G16B25/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US11408037B2
公开(公告)日：2022-08-09
申请号：US16288416
申请日：2019-02-28
申请人： Natera, Inc.
发明人： Joshua Babiarz , Tudor Pompiliu Constantin , Lane A. Eubank , George Gemelos , Matthew Micah Hill , Huseyin Eser Kirkizlar , Matthew Rabinowitz , Onur Sakarya , Styrmir Sigurjonsson , Bernhard Zimmermann
IPC分类号： C12Q1/6886 , C12Q1/6869 , G16B20/00 , G06N20/00 , G16B15/00 , G16B25/00 , G16B40/00 , G16B40/20 , G16B20/10 , G16B20/20 , G16Z99/00 , G16H50/20 , G06N7/00 , G16H10/40 , G16B25/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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