中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

23 records (took 0.019 seconds)

    Process for halohydrin preparation
    12.
    发明授权
    Process for halohydrin preparation 失效
    卤代醇制备方法

    公开(公告)号：US06362343B1

    公开(公告)日：2002-03-26

    申请号：US09693687

    申请日：2000-10-23

    Applicant: Neil W. Boaz

    Inventor： Neil W. Boaz

    IPC: C07D23384

    CPC classification number: C07D307/20

    Abstract: A process for preparing a halohydrin of a water-miscible olefin comprising: reacting a water-miscible olefin in water with a compound of the formula (I) wherein R1 and R2 independently represent a branched or unbranched, substituted or unsubstituted, lower alkyl having from 1 to 5 carbons and X is a halogen, to thereby form the halohydrin of the water-miscible olefin.

    Abstract translation: 一种制备水混溶性烯烃的卤代醇的方法，包括：使水中可与水混合的烯烃与水与式（I）化合物反应，其中R 1和R 2独立地表示支链或非支链的取代或未取代的低级烷基， 1至5个碳，X是卤素，从而形成水混溶性烯烃的卤代醇。

    Process for the preparation of thioether-substituted aromatic ketones
    14.
    发明授权
    Process for the preparation of thioether-substituted aromatic ketones 失效
    制备硫醚取代的芳族酮的方法

    公开(公告)号：US6096929A

    公开(公告)日：2000-08-01

    申请号：US369300

    申请日：1999-08-06

    Applicant: Neil W. Boaz

    Inventor： Neil W. Boaz

    IPC: C07C201/12 ,  C07C205/11 ,  C07C205/45 ,  C07C319/14 ,  C07C323/22 ,  C07C205/00

    CPC classification number: C07C319/14 ,  C07C201/12

    Abstract: The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds.

    Abstract translation: 在邻位置由硫醚基取代的芳族酮的制备通过在氢氧化物碱存在下，用卤化物和邻硝基取代的芳香核与硝基烷烃的初始反应来实现。 所得邻硝基烷基硝基芳烃化合物通过氧化Nef反应转化成相应的邻硝基芳基酮。 通过与硫醇盐阴离子反应，最优选在相转移条件下，邻硝基芳基酮的芳基硝基被硫醚基取代。 芳族酮可用于制备各种药物和除草化合物。

    Alcohol-ester sparation by reaction with acetate
    15.
    发明授权
    Alcohol-ester sparation by reaction with acetate 失效
    乙酸酯与乙酸酯反应制备醇酯

    公开(公告)号：US5126268A

    公开(公告)日：1992-06-30

    申请号：US660839

    申请日：1991-02-26

    Applicant: Neil W. Boaz

    Inventor： Neil W. Boaz

    IPC: C07C303/44 ,  C07C309/73 ,  C07C309/74 ,  C07C309/76

    CPC classification number: C07B57/00 ,  C07C303/44 ,  C12P11/00 ,  C12P41/003

    Abstract: A process is disclosed for the isolation of an enantiomerically enriched alcohol from a first mixture of an enantiomerically enriched 1-arylsulfonate-2 -hydroxy-3-butene and an enantiomerically enriched 1 -arylsulfonate- 2-acyloxy-3-butene. The process includes the steps of:(a) contacting the mixture with a reagent capable of reacting with said 1-arylsulfonate-2-hydroxy-3-butene to remove the arylsulfonate group and produce a mixture of dihydroxybutene monoesters thereby forming a second mixture containing said dihydroxybutene monoesters and unreacted enantiomerically enriched 1-arylsulfonate-2-acyloxy-3-butene(b) contacting the second mixture with reagents capable of hydrolyzing all of the acyl groups in said mixture to hydroxy groups so as to produce a third mixture comprising 1,2-dihydroxy-3-butenes and enantiomerically enriched 1-arylsulfonate-2-hydroxy-3 -butene;(c) washing said third mixture with water so as to remove said 1,2-dihydroxy-3-butenes.

    Abstract translation: 公开了从对映异构体富集的1-芳基磺酸酯-2-羟基-3-丁烯和对映体富集的1-芳基磺酸酯-2-酰氧基-3-丁烯的第一混合物中分离对映体富集的醇的方法。 该方法包括以下步骤：（a）使混合物与能够与所述1-芳基磺酸酯-2-羟基-3-丁烯反应的试剂接触以除去芳基磺酸酯基团并产生二羟基丁烯单酯的混合物，从而形成含有 所述二羟基丁烯单酯和未反应的对映异构体富集的1-芳基磺酸酯-2-酰氧基-3-丁烯（b）使第二混合物与能够将所述混合物中所有酰基水解成羟基的试剂接触，从而产生第三混合物，其包含1 2-二羟基-3-丁烯和对映体富集的1-芳基磺酸酯-2-羟基-3-丁烯; （c）用水洗涤所述第三混合物，以除去所述1,2-二羟基-3-丁烯。

    Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation
    18.
    发明授权
    Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation 失效
    具有高对映体纯度的光学活性顺式-1,3-环己烷二羧酸单酯及其制备方法

    公开(公告)号：US06210956B1

    公开(公告)日：2001-04-03

    申请号：US09344370

    申请日：1999-06-25

    Applicant: Neil W. Boaz

    Inventor： Neil W. Boaz

    IPC: C12P4100

    CPC classification number: C07C69/75

    Abstract: Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters of >90% enantiomeric excess (ee) and methods of preparing the monoesters are described. One method contacts a cis-1,3-cyclohexanedicarboxylic acid diester with a lipase under aqueous conditions to enantioselectively produce the optically active cis-1,3-cyclohexanedicarboxylic acid monoester. Another method reacts a mixture of cis- and trans-1,3-cyclohexanedicarboxylic acids under conditions sufficient to form a cis-cyclic anhydride, esterifies the cis-cyclic anhydride to produce a cis-1,3-cyclohexanedicarboxylic acid diester and then contacts under aqueous conditions the diester with a lipase to enantioselectively produce the optically active cis-1,3-cyclohexanedicarboxylic acid monoester.

    Abstract translation: 描述了> 90％对映异构体过量（ee）的光学活性顺式-1,3-环己烷二羧酸单酯和制备单酯的方法。 一种方法在水性条件下与脂肪酶接触顺式-1,3-环己烷二羧酸二酯以对映选择性地制备光学活性顺式-1,3-环己烷二羧酸单酯。 在足以形成顺式 - 环状酸酐的条件下，另一种方法使顺式 - 和反式-1,3-环己烷二羧酸的混合物反应，酯化顺式 - 环状酸酐以产生顺式-1,3-环己烷二羧酸二酯，然后在 水溶液用脂肪酶条件使二酯对映选择性地产生光学活性的顺式-1,3-环己烷二羧酸单酯。

    Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation
    19.
    发明授权
    Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation 失效
    具有高对映体纯度的光学活性顺式-1,3-环己烷二羧酸单酯及其制备方法

    公开(公告)号：US6028213A

    公开(公告)日：2000-02-22

    申请号：US60959

    申请日：1998-04-16

    Applicant: Neil W. Boaz

    Inventor： Neil W. Boaz

    IPC: C07C69/75 ,  C07C69/74

    CPC classification number: C07C69/75

    Abstract: Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters of >90% enantiomeric excess (ee) and methods of preparing the monoesters are described. One method contacts a cis-1,3-cyclohexanedicarboxylic acid diester with a lipase under aqueous conditions to enantioselectively produce the optically active cis-1,3-cyclohexanedicarboxylic acid monoester. Another method reacts a mixture of cis- and trans-1,3-cyclohexanedicarboxylic acids under conditions sufficient to form a cis-cyclic anhydride, esterifies the cis-cyclic anhydride to produce a cis-1,3-cyclohexanedicarboxylic acid diester and then contacts under aqueous conditions the diester with a lipase to enantioselectively produce the optically active cis-1,3-cyclohexanedicarboxylic acid monoester.

    Abstract translation: 描述了> 90％对映异构体过量（ee）的光学活性顺式-1,3-环己烷二羧酸单酯和制备单酯的方法。 一种方法在水性条件下与脂肪酶接触顺式-1,3-环己烷二羧酸二酯以对映选择性地制备光学活性顺式-1,3-环己烷二羧酸单酯。 在足以形成顺式 - 环状酸酐的条件下，另一种方法使顺式 - 和反式-1,3-环己烷二羧酸的混合物反应，酯化顺式 - 环状酸酐以产生顺式-1,3-环己烷二羧酸二酯，然后在 水溶液用脂肪酶条件使二酯对映选择性地产生光学活性的顺式-1,3-环己烷二羧酸单酯。

Patent Agency Ranking